ARIH2

ARIH2
Identifiers
Aliases	ARIH2 , ARI2, TRIAD1, ariadne RBR E3 ubiquitin protein ligase 2
External IDs	OMIM: 605615; MGI: 1344361; HomoloGene: 48424; GeneCards: ARIH2; OMA:ARIH2 - orthologs
Gene location (Mouse) Chr. Chromosome 9 (mouse) [1] Band 9|9 F2 Start 108,480,141 bp [1] End 108,526,585 bp [1]
Gene ontology Molecular function ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity protein binding transferase activity ubiquitin conjugating enzyme binding zinc ion binding Cellular component cytoplasm nucleus nucleoplasm Cul5-RING ubiquitin ligase complex Biological process developmental cell growth positive regulation of protein targeting to mitochondrion protein K63-linked ubiquitination hematopoietic stem cell proliferation protein polyubiquitination multicellular organism development protein K48-linked ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10425 23807 Ensembl ENSG00000177479 ENSMUSG00000064145 UniProt O95376 Q9Z1K6 RefSeq (mRNA) NM_006321 NM_001317333 NM_001317334 NM_011790 NM_001357283 NM_001357285 NM_001357286 RefSeq (protein) NP_001304262 NP_001304263 NP_006312 NP_001336138 NP_001336139 NP_001336140 NP_001336141 NP_001336142 NP_001336143 NP_001336144 NP_001336145 NP_001336146 NP_001336147 NP_001336148 NP_001336149 NP_001336150 NP_001336151 NP_001336152 NP_001336153 NP_001336154 NP_001336155 NP_001336156 NP_001336157 NP_001336158 NP_001336159 NP_035920 NP_001344212 NP_001344214 NP_001344215 Location (UCSC) n/a Chr 9: 108.48 – 108.53 Mb PubMed search [2] [3]
Wikidata
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Protein ariadne-2 homolog is a protein that is encoded by the ARIH2 gene in humans. ^{[4] [5]}

Function

ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulates the proliferation, ^[6] DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination, ^[7] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages. ^[8]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000064145 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (July 1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Science. 8 (7): 1557–1561. doi:10.1110/ps.8.7.1557. PMC   2144383 . PMID   10422847.
5. "Entrez Gene: ARIH2 ariadne homolog 2 (Drosophila)".
6. Wang H, Bei L, Shah CA, Huang W, Platanias LC, Eklund EA (May 2018). "The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia". Oncogene. 37 (19): 2532–2544. doi:10.1038/s41388-018-0131-5. PMC   5945580 . PMID   29459712.
7. Geng S, Peng W, Wang X, Hu X, Liang H, Hou J, et al. (June 2022). "ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination". Cell Death & Disease. 13 (6): 564. doi:10.1038/s41419-022-04965-9. PMC   9218151 . PMID   35732617.
8. Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, et al. (November 2017). "ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages". Journal of Immunology. 199 (10): 3614–3622. doi: 10.4049/jimmunol.1700184 . PMID   29021376.

External links

• Human ARIH2 genome location and ARIH2 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (July 2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–1244. doi:10.1093/genetics/155.3.1231. PMC   1461160 . PMID   10880484.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, et al. (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–9548. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (September 2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". The EMBO Journal. 21 (18): 4796–4808. doi:10.1093/emboj/cdf493. PMC   126289 . PMID   12234920.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G, Menke A, de Witte T, et al. (December 2005). "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells". Blood. 106 (13): 4114–4123. doi: 10.1182/blood-2005-04-1450 . PMID   16118314.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Marteijn JA, van der Meer LT, van Emst L, van Reijmersdal S, Wissink W, de Witte T, et al. (November 2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1". Blood. 110 (9): 3128–3135. doi: 10.1182/blood-2006-11-058602 . PMID   17646546.