Agrimol B

Agrimol B

Identifiers
IUPAC name (2S)-1-[3,5-bis[(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylphenyl)methyl]-2,4,6-trihydroxyphenyl]-2-methylbutan-1-one
CAS Number	55576-66-4
PubChem CID	194000
ChemSpider	4475783
CompTox Dashboard (EPA)	80970914
Chemical and physical data
Formula	C37H46O12
Molar mass	682.763 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCC(=O)C1=C(C(=C(C(=C1O)CC2=C(C(=C(C(=C2O)C(=O)[C@@H](C)CC)O)CC3=C(C(=C(C(=C3O)C)OC)C(=O)CCC)O)O)O)C)OC
InChI InChI=1S/C37H46O12/c1-9-12-23(38)25-32(44)19(29(41)17(5)36(25)48-7)14-21-31(43)22(35(47)27(34(21)46)28(40)16(4)11-3)15-20-30(42)18(6)37(49-8)26(33(20)45)24(39)13-10-2/h16,41-47H,9-15H2,1-8H3/t16-/m0/s1 Key:BVLHMPZMQVWDGX-INIZCTEOSA-N

Agrimol B is a natural product which is found in the plant Agrimonia pilosa , which is used in traditional herbal medicine in various countries in East Asia. It has a complex spectrum of activity, acting as an activator of the SIRT1 protein but an inhibitor of various other enzyme targets. In animal studies it has anti-obesity, anti-parasitic and anti-cancer effects. ^{[1] [2] [3] [4] [5] [6]}

References

1. Wang S, Zhang Q, Zhang Y, Shen C, Wang Z, Wu Q, et al. (August 2016). "Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway". Biochemical and Biophysical Research Communications. 477 (3): 454–460. doi:10.1016/j.bbrc.2016.06.078. PMID   27320865.
2. Hnit SS, Ding R, Bi L, Xie C, Yao M, De Souza P, et al. (September 2021). "Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G₀ state arrest". Biomedicine & Pharmacotherapy. 141: 111795. doi: 10.1016/j.biopha.2021.111795 . PMID   34098217.
3. Xiang D, Yang W, Fang Z, Mao J, Yan Q, Li L, et al. (2022). "Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway". Frontiers in Oncology. 12: 1055126. doi: 10.3389/fonc.2022.1055126 . PMC   9794846 . PMID   36591497.
4. Tang J, Li L, Chen Z, Liao C, Hu K, Yang Y, et al. (April 2024). "Agrimol B alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice". Acta Biochimica et Biophysica Sinica. 56 (4): 551–563. doi:10.3724/abbs.2023285. PMC   11090851 . PMID   38404180.
5. Dong L, Luo L, Wang Z, Lian S, Wang M, Wu X, et al. (August 2024). "Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma". Free Radical Biology & Medicine. 220: 111–124. doi:10.1016/j.freeradbiomed.2024.04.242. PMID   38697493.
6. Abudouaini H, Zhang X, Dai Y, Meng Y, Lu Q, Ren Q, et al. (September 2024). "Activating the iNOS regulatory pathway by arginine deprivation targets energy metabolism to induce autophagy-dependent apoptosis against spinal echinococcosis". Biochemical Pharmacology. 227: 116453. doi: 10.1016/j.bcp.2024.116453 . PMID   39059773.