Alex K. Shalek

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Alex Shalek
Alex K. Shalek, PhD.jpg
Alex Shalek, August 2019
Born(1981-12-18)December 18, 1981
Alma mater Columbia University
Harvard University
AwardsJ. W. Kieckhefer Professorship (2023-current)
Avant-Garde (DP1 Pioneer) Award from the National Institute for Drug Abuse (2021)
Harold E. Edgerton Faculty Achievement Award, MIT (2020)
Pew Charitable Trust Pew-Stewart Scholar (2018)
Alfred P. Sloan Foundation Sloan Research Fellow (2018)
Searle Scholars Program (2015)
Beckman Young Investigators Award (2015)
NIH Director's New Innovator Award (2015)
Scientific career
Institutions Massachusetts Institute of Technology
Broad Institute
Koch Institute for Integrative Cancer Research
Ragon Institute
Mass General Hospital
Harvard Medical School
Doctoral advisor Hongkun Park
Website www.shaleklab.com

Alex K. Shalek, a biomedical engineer, is the Director of the Institute for Medical Engineering and Science (IMES) and the J. W. Kieckhefer Professor in IMES and the Department of Chemistry at the Massachusetts Institute of Technology. He is an Extramural Member of the Koch Institute for Integrative Cancer Research at MIT. Additionally, he is a Member of the Ragon Institute, an Institute Member of the Broad Institute, an Assistant in Immunology at Massachusetts General Hospital, and an Instructor in Health Sciences and Technology at Harvard Medical School. The multi-disciplinary research of the Shalek Lab aims to create and implement broadly-applicable methods to study and engineer cellular responses in tissues, to drive biological discovery and improve prognostics, diagnostics, and therapeutics for autoimmune, infectious, and cancerous diseases. Shalek and his lab are best known for their work in single-cell genomics and for studying a number of devastating, but difficult to study, human diseases with partners around the world. [1]

Contents

Education and previous research

Shalek received his B.A. summa cum laude in 2004 from Columbia University where he studied chemical physics as a John Jay Scholar with Richard Bersohn and Louis Brus. He then performed graduate work in chemical physics developing arrays of nanowires as cellular "syringes" and electrochemical probes under the direction of Hongkun Park at Harvard University. [2] After, as a postdoctoral fellow, under the direction of Park and Aviv Regev at the Broad Institute, Shalek helped pioneer single-cell patterns in cellular responses to study how cells respond differently to the same condition, showing that genome-wide gene expression covariation across cells could be used to define cellular types and states, their internal "circuitry", from the “bottom-up”. [3] [4] [5] [6]

As an independent investigator, Shalek and his lab have helped scale and simplify single cell genomics to study complex, low-input clinical specimens around the world. [7] [5] [8] In parallel, they have used these and other approaches [8] [9] [10] [11] [12] [13] [14] [ excessive citations ] to help examine the causes and consequences of cellular heterogeneity across cancers, [15] [16] [17] [18] [19] infectious diseases, [5] [8] [9] [10] [20] [21] [22] [23] [24] [25] [26] [27] [ excessive citations ] and inflammation. [28] [29] [30]

Ongoing research

Current work in the Shalek Lab includes both the development of broadly enabling technologies as well as their application to characterize, model, and control multicellular systems. With respect to technology development, the lab brings together areas of research in genomics, chemical biology, and nanotechnology to establish accessible approaches to profile and control cells and their interactions.

In addition to these tools with the global research community, [31] the lab is applying them to dissect human diseases, like COVID-19, [32] [33] methodically linking cellular features and clinical observations. Major areas of focus include how: immune cells coordinate balanced responses to environmental stresses; [28] [29] [8] [34] host cell-pathogen interactions evolve during infection; [8] [9] [10] [21] [22] [23] [26] [ excessive citations ] and, tumor cells evade therapeutic treatment and natural immunity. [15] [17] [18] [19] [25] [35]

From these observations and those of others, the lab aims to understand how disease alters tissue function at the cellular level and realize therapeutic and prophylactic interventions to reestablish or support human health.

Select honors and awards

Select publications

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References

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  35. ↑ Nirschl, Christopher J.; Suárez-Fariñas, Mayte; Izar, Benjamin; Prakadan, Sanjay; Dannenfelser, Ruth; Tirosh, Itay; Liu, Yong; Zhu, Qian; Devi, K. Sanjana P.; Carroll, Shaina L.; Chau, David (2017-06-29). "IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment". Cell. 170 (1): 127–141.e15. doi: 10.1016/j.cell.2017.06.016 . ISSN   0092-8674. PMC   5569303 . PMID   28666115.
  36. ↑ "Alex Shalek wins Edgerton Faculty Award". MIT News | Massachusetts Institute of Technology. 23 April 2020. Retrieved 2020-12-11.
  37. ↑ "Excellence in Mentoring Awards". The Office for Diversity Inclusion and Community Partnership at Harvard Medical School. Retrieved 2020-12-11.
  38. ↑ "Shalek named 2018 Pew-Stewart Scholar for Cancer Research – MIT Department of Chemistry". 14 June 2018. Retrieved 2020-12-11.
  39. ↑ "IMES Professor Alex Shalek wins 2018 Sloan Research Fellowship". Institute for Medical Engineering & Science. 2018-02-15. Retrieved 2021-02-09.
  40. ↑ "Alex Shalek named Pfizer-Laubach Career Development Professor – Shalek Lab". shaleklab.com. 2 July 2017. Retrieved 2020-12-11.
  41. ↑ "Previous ASAs | Science Translational Medicine". stm.sciencemag.org. Retrieved 2021-02-17.
  42. ↑ "Shalek Awarded NIH New Innovator Award". Ragon Institute of MGH, MIT and Harvard. 2015-10-06. Retrieved 2020-12-11.
  43. ↑ "Alex Shalek". Arnold and Mabel Beckman Foundation. Retrieved 2020-12-11.
  44. ↑ "Searle Scholars Program". Scholar Profile Alex Shalek. Archived from the original on September 5, 2015. Retrieved 2 June 2023.
  45. 1 2 3 4 5 6 7 8 "Alex K. Shalek". Institute for Medical Engineering & Science. Retrieved 2021-02-09.
  46. ↑ Yosef, Nir; Shalek, Alex K.; Gaublomme, Jellert T.; Jin, Hulin; Lee, Youjin; Awasthi, Amit; Wu, Chuan; Karwacz, Katarzyna; Xiao, Sheng; Jorgolli, Marsela; Gennert, David (April 2013). "Dynamic regulatory network controlling T H 17 cell differentiation". Nature. 496 (7446): 461–468. Bibcode:2013Natur.496..461Y. doi:10.1038/nature11981. ISSN   1476-4687. PMC   3637864 . PMID   23467089.
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