Aviv Regev

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Aviv Regev
Aviv Regev ISMB 2017 (cropped).jpg
Regev at the Intelligent Systems for Molecular Biology conference in 2017
Born (1971-07-11) July 11, 1971 (age 53) [1]
Alma mater Tel Aviv University (M.Sc., Ph.D.)
Awards
Scientific career
Fields Bioinformatics
Computational Biology
Institutions
Doctoral advisor Eva Jablonka
Ehud Shapiro
Website www.gene.com/scientists/our-scientists/aviv-regev OOjs UI icon edit-ltr-progressive.svg

Aviv Regev (born 11 July 1971) [1] is a computational biologist and systems biologist and Executive Vice President and Head of Genentech Research and Early Development in Genentech/Roche. [4] She is a core member (on leave) at the Broad Institute of MIT and Harvard and professor (on leave) at the Department of Biology of the Massachusetts Institute of Technology. [5] Regev is a pioneer of single cell genomics and of computational and systems biology of gene regulatory circuits. She founded and leads the Human Cell Atlas project, [6] together with Sarah Teichmann.

Contents

Education

Regev studied at the Adi Lautman Interdisciplinary Program for Outstanding Students of Tel Aviv University, where she completed her PhD under the supervision of Eva Jablonka, [7] and Ehud Shapiro. [8]

Career and research

In 2020, Regev became the Head and Executive Vice President of Genentech Research and Early Development, based in South San Francisco, and a member of the extended Corporate Executive Committee of Roche. [9] [10] Previously, she was a Core Institute Member (now on leave), Chair of the Faculty, Founding Director of the Klarman Cell Observatory and co-Director Cell Circuits Program at the Broad Institute of MIT and Harvard. She was also a professor in the Department of Biology at the Massachusetts Institute of Technology (now on leave), as well as an Investigator at the Howard Hughes Medical Institute. Regev's research [11] includes work on gene expression [12] [13] (with Eran Segal and David Botstein), and the use of π-calculus to represent biochemical processes. [14] [15] [16] Regev's team has been a leading pioneer of single-cell genomics experimental and computational methods. [17] In 2014, she pitched the idea of the creation of Human Cell Atlas, [18] a project to describe all cell types in the human body. Regev founded the Human Cell Atlas together with Sarah Teichmann along with collaborators all over the world.[ citation needed ]

Single Cell Genomics

Regev's lab pioneered the development and application of many of the key experimental and computational advances for single cell and spatial genomics, especially single cell RNA-Seq (scRNA-seq).

Awards and honors

Regev is a fellow of the International Society of Computational Biology (ISCB) (2017), [19] a Helmholtz Fellow (2020), [20] and a fellow of the American Association for Cancer Research (AACR) (2021). [21] She is a member of the US National Academy of Sciences (NAS, elected 2019) [22] and of the US National Academy of Medicine (NAM, elected 2020). [23] She was elected as a foreign member of the Royal Society [24] and as an associate member of the European Molecular Biology Organization in 2024. [25]

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References

  1. 1 2 "Aviv Regev" (PDF). broadinstitute.org. Archived from the original (PDF) on 16 November 2017. Retrieved 2 December 2021.
  2. 1 2 Sansom, C.; Morrison Mckay, B. J. (2008). Bourne, Philip E. (ed.). "ISCB Honors David Haussler and Aviv Regev". PLOS Computational Biology . 4 (7): e1000101. Bibcode:2008PLSCB...4E0101S. doi: 10.1371/journal.pcbi.1000101 . PMC   2536508 . PMID   18795145. Open Access logo PLoS transparent.svg
  3. 1 2 Fogg, Christiana N.; Kovats, Diane E.; Berger, Bonnie (2017). "2017 ISCB Innovator Award: Aviv Regev". PLOS Computational Biology . 13 (6): e1005558. Bibcode:2017PLSCB..13E5558F. doi: 10.1371/journal.pcbi.1005558 . ISSN   1553-7358. PMC   5493285 . PMID   28665936. Open Access logo PLoS transparent.svg
  4. ↑ GENENTECH EXECUTIVE COMMITTEE, accessed 6 August 2020.
  5. ↑ "Aviv Regev at MIT". biology.mit.edu. Archived from the original on 6 April 2017. Retrieved 5 November 2017.
  6. ↑ Nowogrodzki, Anna (5 July 2017). "How to build a human cell atlas". Nature . 547 (7661): 24–26. Bibcode:2017Natur.547...24N. doi: 10.1038/547024a . PMID   28682347. S2CID   211067156.
  7. ↑ Regev, A.; Lamb, M. J.; Jablonka, E. (1998). "The Role of DNA Methylation in Invertebrates: Developmental Regulation or Genome Defense?". Molecular Biology and Evolution . 15 (7): 880. doi: 10.1093/oxfordjournals.molbev.a025992 . ISSN   0737-4038.
  8. ↑ Regev, A.; Shapiro, E. (2002). "Cellular abstractions: Cells as computation". Nature. 419 (6905): 343. Bibcode:2002Natur.419..343R. doi:10.1038/419343a. PMC   3842595 . PMID   12353013. Closed Access logo transparent.svg
  9. ↑ Taylor, Nick Paul (11 May 2020). "Genentech lures Regev from Broad Institute to lead research and early development". fiercebiotech.com. Retrieved 25 May 2020.
  10. ↑ "Changes to the Roche Enlarged Corporate Executive Committee" (Press release). Basel, Switzerland: F. Hoffmann-La Roche Ltd. globenewswire. 11 May 2020. Retrieved 25 May 2020.
  11. ↑ Search Results for author Regev A on PubMed .
  12. ↑ Segal, E.; Shapira, M.; Regev, A.; Pe'er, D.; Botstein, D.; Koller, D.; Friedman, N. (2003). "Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data". Nature Genetics . 34 (2): 166–176. doi:10.1038/ng1165. PMID   12740579. S2CID   6146032.
  13. ↑ Segal, E.; Friedman, N.; Koller, D.; Regev, A. (2004). "A module map showing conditional activity of expression modules in cancer". Nature Genetics . 36 (10): 1090–1098. doi: 10.1038/ng1434 . PMC   2271138 . PMID   15448693. Closed Access logo transparent.svg
  14. ↑ Regev, A.; Silverman, W.; Shapiro, E. (2001). "Representation and simulation of biochemical processes using the pi-calculus process algebra". Pacific Symposium on Biocomputing : 459–470. doi:10.1142/9789814447362_0045. ISBN   978-981-02-4515-3. PMID   11262964.
  15. ↑ Priami, C.; et al. (2001). "Application of a stochastic name-passing calculus to representation and simulation of molecular processes" (PDF). Information Processing Letters. 80: 25–31. doi:10.1016/S0020-0190(01)00214-9. Closed Access logo transparent.svg
  16. ↑ Study provides insight into regenerative potential of prostate gland, News Medical, accessed 4 May 2020.
  17. ↑ "Aviv Regev". HHMI.org. Retrieved 11 May 2020.
  18. ↑ The Human Cell Atlas – Aviv Regev, August 2014, retrieved 30 May 2022
  19. ↑ "2017 ISCB Innovator Award: Aviv Regev". www.iscb.org. Retrieved 14 March 2022.
  20. ↑ "Event – Helmholtz Zentrum München". www.helmholtz-munich.de. Retrieved 14 March 2022.
  21. ↑ "Aviv Regev, PhD, FAACR | Scientific Awards | AACR". American Association for Cancer Research (AACR). Retrieved 14 March 2022.
  22. ↑ "Aviv Regev". www.nasonline.org. Retrieved 14 March 2022.
  23. ↑ "National Academy of Medicine Elects 100 New Members". National Academy of Medicine. 19 October 2020. Retrieved 14 March 2022.
  24. ↑ "Outstanding scientists elected as Fellows of the Royal Society".
  25. ↑ "EMBO elects 2024 members".
  26. ↑ "Aviv Regev: Can AI Help Develop New Medicines". 9 August 2024.
  27. ↑ "Discover the laureates of the 25th L'Oréal-UNESCO For Women in Science International Awards | UNESCO". www.unesco.org. Retrieved 2 June 2023.
  28. ↑ "New Members". American Academy of Arts & Sciences. Retrieved 30 May 2022.
  29. ↑ "The Events Calendar".
  30. ↑ "Press Release – 2022 HFSP Nakasone Award".
  31. ↑ Foppa, Carolin Arndt (22 November 2021). "Pioneer in bioinformatics receives ETH Honorary doctorate". bsse.ethz.ch. Retrieved 18 March 2022.
  32. ↑ "Ernst Schering Prize 2021 – Schering Stiftung" . Retrieved 18 March 2022.
  33. ↑ "James Prize in Science and Technology Integration". www.nasonline.org. Retrieved 18 March 2022.
  34. ↑ Snyder, Bill (28 April 2021). "Regev receives Vanderbilt Prize in Biomedical Science". Vanderbilt University. Retrieved 18 March 2022.
  35. ↑ "Award Ceremony for the 25th Keio Medical Science Prize". keio.ac.jp. Retrieved 22 December 2020.
  36. ↑ "Announcement of the 25th Keio Medical Science Prize – News – Keio University Medical Science Fund". www.ms-fund.keio.ac.jp. Retrieved 18 March 2022.
  37. ↑ "Aviv Regev, PhD, FAACR | Scientific Awards | AACR". American Association for Cancer Research (AACR). Retrieved 18 March 2022.
  38. ↑ "2020 FNIH Lurie Prize in Biomedical Sciences Winner Pioneered Innovative Techniques to Shed New Light on Human Health | The Foundation for the National Institutes of Health". fnih.org. 18 June 2020. Retrieved 18 March 2022.
  39. ↑ Wimmer, Doris. "Aviv Regev". ESHG Conference 2020. Retrieved 14 March 2022.
  40. ↑ "Kraft Prize Symposium". Massachusetts General Hospital. Retrieved 14 March 2022.
  41. ↑ "Past Recipients". www.faseb.org. Retrieved 14 March 2022.
  42. ↑ "2019 NAS Election". nasonline.org. Retrieved 30 April 2019.
  43. ↑ "Weatherall Lectures — MRC Weatherall Institute of Molecular Medicine". www.imm.ox.ac.uk. Retrieved 14 March 2022.
  44. ↑ "The Harvey Society: Series 113, Lecture 5". harveysociety.org. Retrieved 14 March 2022.
  45. ↑ "MIT's Aviv Regev to present annual McCormick Lecture Feb. 1". News Center (in Samoan). Retrieved 14 March 2022.
  46. ↑ "2017 Prize Winners". Memorial Sloan Kettering Cancer Center. Retrieved 12 December 2017.
  47. ↑ "February 09, 2017: ISCB Announces 2017 Award Recipients". iscb.org. Retrieved 10 February 2017.
  48. ↑ "Regev recognized for rigorous integration of experimental and computational approaches". www.asbmb.org. Retrieved 14 March 2022.
  49. ↑ Dynamic single-cell imaging of direct reprogramming reveals an early specifying event – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface; Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface.
  50. ↑ "Three faculty win '08 NIH Pioneer Awards". MIT News | Massachusetts Institute of Technology. 22 September 2008. Retrieved 6 March 2022.
  51. ↑ "2008 NIH Director's Pioneer Award". Archived from the original on 30 July 2019. Retrieved 30 July 2019.
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