David Eisenberg

Last updated
David Eisenberg
David Eisenberg - journal.pcbi.1003116.g001.png
David Eisenberg
Born (1939-03-15) March 15, 1939 (age 85)
Chicago, Illinois, US
Alma mater Harvard University (undergraduate)
The Queen's College, Oxford (postgraduate)
Awards Harvey Prize (2008)
ISCB Senior Scientist Award (2013) [1]
Scientific career
Fields Proteins [2]
Amyloid [3]
Structural biology [4] [5] [6]
Institutions Howard Hughes Medical Institute
University of Oxford
University of California, Los Angeles
Harvard University
California Institute of Technology
Princeton University
Thesis Some problems in the electronic structure of molecules  (1965)
Doctoral advisor Charles Coulson [ citation needed ]
Notable students
Website

David S. Eisenberg (born 15 March 1939[ citation needed ]) is an American biochemist and biophysicist best known for his contributions to structural biology and computational molecular biology. He has been a professor at the University of California, Los Angeles since the early 1970s and was director of the UCLA-DOE Institute for Genomics & Proteomics, as well as a member of the California NanoSystems Institute (CNSI) at UCLA. [9] [10] [11] [12] [13] [14] [15]

Contents

Education

Eisenberg attended Harvard University and graduated in 1961 with an A.B. in Biochemical Sciences. He went on to the University of Oxford, where he was awarded a D.Phil in 1965 [16] for research supervised by Charles Coulson.

Research

Eisenberg's current research focuses on the structural biology of amyloidogenic proteins, while his computational efforts largely center on the development of bioinformatic/proteomic methodologies for elucidation and analysis of protein interaction networks. His research group hosts the Database of Interacting Proteins. [17]

Career

Awards

He was the recipient of Harvey Prize (Human Health) 2008 in recognition of his contributions in unfolding the structure of amyloid fibrils. The award was presented to him at a ceremony that took place on March 23, 2009 at the Technion. This recently recognized protein state provides opportunities to understand cells in health and disease. [18]

Related Research Articles

<span class="mw-page-title-main">Bioinformatics</span> Computational analysis of large, complex sets of biological data

Bioinformatics is an interdisciplinary field of science that develops methods and software tools for understanding biological data, especially when the data sets are large and complex. Bioinformatics uses biology, chemistry, physics, computer science, computer programming, information engineering, mathematics and statistics to analyze and interpret biological data. The subsequent process of analyzing and interpreting data is referred to as computational biology.

<span class="mw-page-title-main">Proteomics</span> Large-scale study of proteins

Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body.

<span class="mw-page-title-main">Leroy Hood</span> American biologist (born 1938)

Leroy "Lee" Edward Hood is an American biologist who has served on the faculties at the California Institute of Technology (Caltech) and the University of Washington. Hood has developed ground-breaking scientific instruments which made possible major advances in the biological sciences and the medical sciences. These include the first gas phase protein sequencer (1982), for determining the sequence of amino acids in a given protein; a DNA synthesizer (1983), to synthesize short sections of DNA; a peptide synthesizer (1984), to combine amino acids into longer peptides and short proteins; the first automated DNA sequencer (1986), to identify the order of nucleotides in DNA; ink-jet oligonucleotide technology for synthesizing DNA and nanostring technology for analyzing single molecules of DNA and RNA.

<span class="mw-page-title-main">Systems biology</span> Computational and mathematical modeling of complex biological systems

Systems biology is the computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach to biological research.

Benjamin Franklin Cravatt III is a professor in the Department of Chemistry at The Scripps Research Institute in La Jolla, California. Considered a co-inventor of activity-based proteomics and a substantial contributor to research on the endocannabinoid system, he is a prominent figure in the nascent field of chemical biology. Cravatt was elected to the National Academy of Sciences in 2014, and the American Academy of Arts and Sciences in 2016. He is Gilula Chair of Chemical Biology, a Cope Scholar, and a Searle Scholar.

<span class="mw-page-title-main">Kendall Houk</span> American chemist

Kendall Newcomb Houk is a Distinguished Research Professor in Organic Chemistry at the University of California, Los Angeles. His research group studies organic, organometallic, and biological reactions using the tools of computational chemistry. This work involves quantum mechanical calculations, often with density functional theory, and molecular dynamics, either quantum dynamics for small systems or force fields such as AMBER, for solution and protein simulations.

Edward Marcotte is a professor of biochemistry at The University of Texas at Austin, working in genetics, proteomics, and bioinformatics. Marcotte is an example of a computational biologist who also relies on experiments to validate bioinformatics-based predictions.

Leonard H. Rome is a cell biologist and biochemist who has been a faculty member of the David Geffen School of Medicine at UCLA, since he joined the Department of Biological Chemistry there, in 1979. He became a full professor in 1988 and has also served as the Senior Associate Dean for Research in the Geffen School of Medicine from 1997 to 2012. He is the Associate Director of the California NanoSystems Institute (CNSI) since 2004, and was Interim Director from 2007-2009. In addition, he served from 2001 to 2005 as University of California, Los Angeles (UCLA) Associate Vice Chancellor for Research for the Life and Health Sciences.

Richard Dale Smith is a chemist and a Battelle Fellow and chief scientist within the biological sciences division, as well as the director of proteomics research at the Pacific Northwest National Laboratory (PNNL). Smith is also director of the NIH Proteomics Research Resource for Integrative Biology, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member at the University of Idaho and the Department of Molecular Microbiology & Immunology, Oregon Health & Science University. He is the author or co-author of approximately 1100 peer-reviewed publications and has been awarded 70 US patents.

<span class="mw-page-title-main">Ruth Nussinov</span> Bioinformatician

Ruth Nussinov is an Israeli-American biologist born in Rehovot who works as a Professor in the Department of Human Genetics, School of Medicine at Tel Aviv University and is the Senior Principal Scientist and Principal Investigator at the National Cancer Institute, National Institutes of Health. Nussinov is also the Editor in Chief of the Current Opinion in Structural Biology and formerly of the journal PLOS Computational Biology.

<span class="mw-page-title-main">Erin K. O'Shea</span> American biologist

Erin K. O'Shea is an American biologist who is president of the Howard Hughes Medical Institute (HHMI). In 2013, she was named HHMI's vice president and chief scientific officer. Prior to that, she was a professor of molecular and cellular biology and chemistry and chemical biology at Harvard University. In 2016, her appointment as future, and first woman, president of HHMI was announced. She has been a Howard Hughes Medical Institute (HHMI) investigator since 2000.

<span class="mw-page-title-main">Tim Hubbard</span> Professor of Bioinformatics at Kings College London

Timothy John Phillip Hubbard is a Professor of Bioinformatics at King's College London, Head of Genome Analysis at Genomics England and Honorary Faculty at the Wellcome Trust Sanger Institute in Cambridge, UK. From 1 March 2024, Hubbard became the director of Europe's Life Science Data Infrastructure ELIXIR.

Sheena Elizabeth Radford FRS FMedSci is a British biophysicist, and Astbury Professor of Biophysics in the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology at the University of Leeds. Radford is the Associate Editor of the Journal of Molecular Biology.

<span class="mw-page-title-main">Bonnie Berger</span> American mathematician and computer scientist

Bonnie Anne Berger is an American mathematician and computer scientist, who works as the Simons professor of mathematics and professor of electrical engineering and computer science at the Massachusetts Institute of Technology. She is the head of the Computation and Biology group at MIT's Computer Science and Artificial Intelligence Laboratory. Her research interests are in algorithms, bioinformatics and computational molecular biology.

Narayanaswamy Srinivasan was an Indian molecular biophysicist and a professor and the head of Proteins: Structure, Function and Evolutionary Group at the Molecular Biophysics Unit of the Indian Institute of Science. He is known for his researches in the fields of computational genomics and protein structure analysis. An elected fellow of the Indian Academy of Sciences and the National Academy of Sciences, India, he is a J. C. Bose National fellow of the Department of Biotechnology and a recipient of the National Bioscience Award for Career Development of the Department of Science and Technology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2007, for his contributions to biological sciences.

Debasis Dash is an Indian computational biologist and chief scientist at the Institute of Genomics and Integrative Biology (IGIB). Known for his research on proteomics and Big Data and Artificial Intelligence studies, his studies have been documented by way of a number of articles and ResearchGate, an online repository of scientific articles has listed 120 of them. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2014. He was appointed as the director of Institute of Life Sciences, Bhubaneswar on 18 May 2023.

<span class="mw-page-title-main">Christophe Dessimoz</span>

Christophe Dessimoz is a Swiss National Science Foundation (SNSF) Professor at the University of Lausanne, Associate Professor at University College London and a group leader at the Swiss Institute of Bioinformatics. He was awarded the Overton Prize in 2019 for his contributions to computational biology. Starting in April 2022, he will be joint executive director of the SIB Swiss Institute of Bioinformatics, along with Ron Appel.

Sabeeha Sabanali Merchant is a professor of plant biology at the University of California, Berkeley. She studies the photosynthetic metabolism and metalloenzymes In 2010 Merchant led the team that sequenced the Chlamydomonas genome. She was elected a member of the National Academy of Sciences in 2012.

Christine Vogel is a German-American molecular biologist who is an associate professor at the New York University. Her research considers quantitative proteomics. She is particularly interested in protein expression patterns and how these are related to human disease.

<span class="mw-page-title-main">John Anthony Schellman</span> American biophysical chemist (1924–2014)

John Anthony Schellman was an American biophysical chemist at the University of Oregon, a member of the National Academy of Sciences, a Biophysical Society Fellow, and an American Physical Society Fellow.

References

  1. ↑ Fogg, C. N.; Kovats, D. E. (2013). "International Society for Computational Biology Honors David Eisenberg with 2013 Accomplishment by a Senior Scientist Award". PLOS Computational Biology. 9 (6): e1003116. Bibcode:2013PLSCB...9E3116F. doi: 10.1371/journal.pcbi.1003116 . PMC   3681620 .
  2. ↑ Eisenberg, D.; McLachlan, A. D. (1986). "Solvation energy in protein folding and binding". Nature. 319 (6050): 199–203. Bibcode:1986Natur.319..199E. doi:10.1038/319199a0. PMID   3945310. S2CID   21867582.
  3. ↑ Balbirnie, M.; Grothe, R.; Eisenberg, D. S. (2001). "An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta -sheet structure for amyloid". Proceedings of the National Academy of Sciences. 98 (5): 2375–2380. Bibcode:2001PNAS...98.2375B. doi: 10.1073/pnas.041617698 . PMC   30146 . PMID   11226247.
  4. ↑ Lüthy, R.; Bowie, J. U.; Eisenberg, D. (1992). "Assessment of protein models with three-dimensional profiles". Nature. 356 (6364): 83–85. Bibcode:1992Natur.356...83L. doi:10.1038/356083a0. PMID   1538787. S2CID   4369151.
  5. ↑ Chapman, M. S.; Suh, S. W.; Curmi, P. M.; Cascio, D.; Smith, W. W.; Eisenberg, D. S. (1988). "Tertiary structure of plant RuBisCO: Domains and their contacts". Science. 241 (4861): 71–74. Bibcode:1988Sci...241...71C. doi:10.1126/science.3133767. PMID   3133767.
  6. ↑ David Eisenberg publications indexed by Google Scholar
  7. ↑ "Former Lab Members | David Eisenberg's Lab".
  8. ↑ "Former Lab Members | David Eisenberg's Lab".
  9. ↑ HHMI profile of David Eisenberg
  10. ↑ The Eisenberg research lab at UCLA
  11. ↑ UCLA-DOE Institute for Genomics & Proteomics
  12. ↑ David Eisenberg’s speech during the Harvey Prize ceremony on YouTube
  13. ↑ Eisenberg, David; Kauzmann, Walter (2005). The structure and properties of water. Oxford: Clarendon Press. ISBN   0-19-857026-0.
  14. ↑ David Eisenberg publications indexed by Microsoft Academic
  15. ↑ David Eisenberg's publications indexed by the Scopus bibliographic database. (subscription required)
  16. ↑ Eisenberg, David J. (1965). Some problems in the electronic structure of molecules (PhD thesis). University of Oxford.
  17. ↑ Salwinski, L.; Miller, C. S.; Smith, A. J.; Pettit, F. K.; Bowie, J. U.; Eisenberg, D. (2004). "The Database of Interacting Proteins: 2004 update". Nucleic Acids Research. 32 (90001): D449–D451. doi:10.1093/nar/gkh086. PMC   308820 . PMID   14681454.
  18. ↑ Harvey Prize Award
  19. ↑ "David S. Eisenberg". www.nasonline.org. Retrieved 2021-09-14.
  20. ↑ "APS Member History". search.amphilsoc.org. Retrieved 2021-09-14.
  21. ↑ "UCLA Glenn T. Seaborg Symposium - Previous Recipients". www.seaborg.ucla.edu. Retrieved 2024-01-05.
  22. ↑ Passano Award 2020
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.