Sarah Amalia Teichmann
April 15, 1975
|Education||European School, Karlsruhe|
|Alma mater||University of Cambridge (BA, MA, PhD)|
|Thesis||Genome evolution: analysing proteomes with new methods (1999)|
|Doctoral advisor||Cyrus Chothia|
|Doctoral students||M. Madan Babu|
Sarah Amalia Teichmann (born 1975) FMedSci is Head of Cellular Genetics at the Wellcome Sanger Institute and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI). She is also a Director of Research (equivalent to Professor) in the Cavendish Laboratory, at the University of Cambridge and a Senior Research Fellow at Churchill College, Cambridge.[ citation needed ]
Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of their achievements".
The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.
The European Bioinformatics Institute (EMBL-EBI) is an IGO which as part of the European Molecular Biology Laboratory (EMBL) family focuses on research and services in bioinformatics.
Teichmann was educated at the European School, Karlsruhe in Germany from 1981 to 1993 where she completed the European Baccalaureate in 1993.Teichmann went on to study the Natural Sciences Tripos at Trinity College, Cambridge and was awarded a first class Bachelor of Arts degree in 1996. In 1999, she completed her PhD supervised by Cyrus Chothia at the Laboratory of Molecular Biology (LMB) on genome evolution.
The European School, Karlsruhe, commonly known as ESK, is one of three official European Schools in Germany. It was the fifth of fourteen such schools to be established in Europe since 1953. The school currently has around one thousand students on role across the kindergarten, primary school and secondary school. The school has offered the European Baccalaureate since 1968.
The European Baccalaureate is a bilingual educational diploma, which certifies the completion of secondary studies in a European School or Accredited European School by the Board of Governors of the intergovernmental organisation, "The European Schools". The diploma is awarded for the successful achievement of coursework and concomitant examinations which require that students take a minimum of 10 courses as well as be fully proficient in two languages. Students may take up to 14 courses. It is officially recognised as an entry qualification for Higher Education in all the member states of the European Union (EU), as well as in a number of others. All participating countries are legally obligated to ensure EB diploma holders enjoy the same rights and benefits as other holders of secondary school-leaving certificates in their jurisdictions. The name ‘European Baccalaureate’ belongs solely to the European Schools, which, since their establishment, have had a monopoly over its use in all the official languages of the EU.
Trinity College is a constituent college of the University of Cambridge in England. With around 600 undergraduates, 300 graduates, and over 180 fellows, it is the largest college in either of the Oxbridge universities by number of undergraduates. In terms of total student numbers, it is second only to Homerton College, Cambridge.
Following her PhD, Teichmann did postdoctoral research supervised by Janet Thornton at University College Londonand funded by the Beit Memorial Fellowships for Medical Research. From 2001-2012, she was a Medical Research Council (MRC) Programme Leader, studying patterns in protein interactions and transcriptional regulatory networks.
Dame Janet Maureen Thornton,HonFRSC is a senior scientist at the European Bioinformatics Institute (EBI), part of the European Molecular Biology Laboratory (EMBL). She is one of the world's leading researchers in structural bioinformatics, using computational methods to understand protein structure and function. She was formerly director of the EBI from October 2001 to June 2015, and played a key role in ELIXIR.
The Beit Memorial Medical Fellowships were one of the most prestigious and competitive fellowships for post-doctoral or medical degree research in medicine in the United Kingdom. The Fellowships were founded in 1909 by Sir Otto Beit, a German-born British financier, philanthropist and art connoisseur, in memory of his brother Alfred Beit.
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK’s seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy.
In 2013 Teichmann was appointed a joint position at the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EMBL-EBI). From 2005 to 2015 she was a teaching fellow and Director of Studies at Trinity College, Cambridge. Since 2016 Teichmann has served as the head of Cellular Genetics at the Wellcome Trust Sanger Instituteand a visiting research group leader at the EBI.
A teaching fellow is an individual at a higher education institution, including universities, whose role involves teaching and potentially pedagogic research. The work done by teaching fellows can vary enormously from institution to institution, depending on the requirements and position of individual institutions.
Teichmann's researchinvestigates gene expression and protein complex assembly using both wet laboratory and computational biology techniques. In particular her research group:
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes, the product is a functional RNA.
Computational biology involves the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological, ecological, behavioral, and social systems. The field is broadly defined and includes foundations in biology, applied mathematics, statistics, biochemistry, chemistry, biophysics, molecular biology, genetics, genomics, computer science and evolution.
|“||...seeks to elucidate the principles of protein structure evolution, higher order protein structure and protein folding, and the principles underlying protein complex formation and organization. We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.||”|
Teichmann's research has been funded by the European Research Council (ERC), the Medical Research Council (MRC), the Biotechnology and Biological Sciences Research Council (BBSRC),the Wellcome Trust, the European Molecular Biology Organization (EMBO), the Framework Programmes for Research and Technological Development and the European Cooperation in Science and Technology (COST).
The European Research Council (ERC) is a public body for funding of scientific and technological research conducted within the European Union (EU). Established by the European Commission in 2007, the ERC is composed of an independent Scientific Council, its governing body consisting of distinguished researchers, and an Executive Agency, in charge of the implementation. It forms part of the framework programme of the union dedicated to research and innovation, Horizon 2020, preceded by the Seventh Research Framework Programme (FP7). The ERC budget is over €13 billion from 2014 – 2020 and comes from the Horizon 2020 programme, a part of the European Union's budget. Under Horizon 2020 it is estimated that around 7,000 ERC grantees will be funded and 42,000 team members supported, including 11,000 doctoral students and almost 16,000 post-doctoral researchers.
Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation, is a NDPB and is the largest UK public funder of non-medical bioscience. It predominantly funds scientific research institutes and university research departments in the UK.
The Wellcome Trust is a biomedical research charity based in London, United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Sir Henry Wellcome to fund research to improve human and animal health. The aim of the Trust is to "achieve extraordinary improvements in health by supporting the brightest minds", and in addition to funding biomedical research it supports the public understanding of science. It has an endowment of £25.9 billion (2018) making it the third wealthiest charitable foundation in the world, after the Bill & Melinda Gates Foundation and the IKEA Foundation.
As of 2015 [update] Teichmann has supervised several PhD students to completion and several postdoctoral researchers who have gone on to become Principal investigators (PIs).
Teichmann has won a number of awards. In 2010, she was awarded Colworth Medal from the Biochemical Society.In 2012, Teichman was awarded the Francis Crick Medal and Lecture, membership of the European Molecular Biology Organization (EMBO) and the Lister Prize from the Lister Institute of Preventive Medicine. In 2015 she was awarded the Michael and Kate Bárány Award for young investigators by the Biophysical Society and the EMBO Gold Medal. Teichmann was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2015. Her citation on election reads:
|“||Sarah Teichmann is Research Group Leader at EMBL-European Bioinformatics Institute and has made major contributions to biology over the past 15 years. A fundamental discovery was her work to define key biophysical mechanisms in protein complex assembly, showing that protein complexes assemble via distinct, ordered pathways. She showed that these assembly pathways are conserved in evolution and how they may be predicted from 3D structure. Her databases and computational analysis methods have had a broad and deep impact on the community. She represents a new breed of scientists at the interface between computational and experimental molecular biology.||”|
Teichmann has also been an activist for women's careers in science through enabling scientists in families to advance their careers while working part-time. [ citation needed ] Teichmann was elected an ISCB Fellow in 2016 by the International Society for Computational Biology.She chaired a Sex in Science debate at the Wellcome Trust on balancing family life with working in research.
Teichmann has two daughters.Teichmann is the co-author of the children's language education novel Teenage Detectives, which she wrote as a teenager together with her mother Dr. Virginia Teichmann, an English-language university lecturer in Karlsruhe.
Michael Ashburner is a biologist and Emeritus Professor in the Department of Genetics at University of Cambridge. He is also the former joint-head and co-founder of the European Bioinformatics Institute (EBI) of the European Molecular Biology Laboratory (EMBL) and a Fellow of Churchill College, Cambridge.
Fotis Constantine Kafatos was a Greek biologist. Between 2007-2010 he was the founding president of the European Research Council (ERC). He chaired the ERC Scientific Council from 2006-2010. Thereafter, he was appointed Honorary President of the ERC.
John Frederick William Birney is joint director with Rolf Apweiler of the European Bioinformatics Institute (EBI), part of the European Molecular Biology Laboratory (EMBL) in Hinxton, Cambridgeshire. He also serves as non-executive director of Genomics England, chair of the Global Alliance for Genomics and Health (GA4GH) and honorary professor of Bioinformatics at the University of Cambridge. Birney has made significant contributions to genomics. Through his development of innovative bioinformatics and computational biology tools, researchers around the world are able to predict and annotate regions of interest in DNA with speed and confidence. He was previously an associate faculty member at the Wellcome Trust Sanger Institute..
Sir Thomas Leon Blundell, is a British biochemist, structural biologist, and science administrator. He was a member of the team of Dorothy Hodgkin that solved in 1969 the first structure of a protein hormone, insulin. Blundell has made contributions to the structural biology of polypeptide hormones, growth factors, receptor activation, signal transduction, and DNA double-strand break repair, subjects important in cancer, tuberculosis, and familial diseases. He has developed software for protein modelling and understanding the effects of mutations on protein function, leading to new approaches to structure-guided and Fragment-based lead discovery. In 1999 he co-founded the oncology company Astex Therapeutics, which has moved ten drugs into clinical trials. Blundell has played central roles in restructuring British research councils and, as President of the UK Science Council, in developing professionalism in the practice of science.
Cyrus Homi Chothia is an English biochemist who is an emeritus scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge and emeritus fellow of Wolfson College, Cambridge.
Rolf Apweiler is a director of European Bioinformatics Institute (EBI) part of the European Molecular Biology Laboratory (EMBL) with Ewan Birney.
Teresa K. Attwood is a Professor of Bioinformatics in the School of Computer Science and School of Biological Sciences at the University of Manchester and a visiting fellow at the European Bioinformatics Institute (EMBL-EBI). She held a Royal Society University Research Fellowship at University College London (UCL) from 1993 to 1999 and at the University of Manchester from 1999 to 2002.
Timothy John Phillip Hubbard is a Professor of Bioinformatics at King's College London, Head of Genome Analysis at Genomics England and Honorary Faculty at the Wellcome Trust Sanger Institute in Cambridge, UK.
Sheena Elizabeth Radford FRS FMedSci is a British biophysicist, and Astbury Professor of Biophysics in the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology at the University of Leeds.
Alexander George Bateman is a computational biologist and Head of Protein Sequence Resources at the European Bioinformatics Institute (EBI), part of the European Molecular Biology Laboratory (EMBL) in Cambridge, UK. He has led the development of the Pfam biological database and introduced the Rfam database of RNA families. He has also been involved in the use of Wikipedia for community-based annotation of biological databases.
Jane Clarke is a British biochemist and academic. Since October 2017, she has served as President of Wolfson College, Cambridge. She is also Professor of Molecular Biophysics, a Wellcome Trust Senior Research Fellow in the Department of Chemistry at the University of Cambridge. She was previously a Fellow of Trinity Hall, Cambridge.
Steve David Macleod Brown FRS FMedSci is director of the Medical Research Council (MRC) Mammalian Genetics Unit, MRC Harwell at Harwell Science and Innovation Campus, Oxfordshire, a research centre on mouse genetics. In addition, he is the head of the Genetics and Pathobiology of Deafness research group there.
David Chaim Rubinsztein FRS FMedSci is the Deputy Director of the Cambridge Institute of Medical Research (CIMR), the Academic Lead of the Alzheimer's Research UK (ARUK) Cambridge Drug Discovery Institute,, Professor of Molecular Neurogenetics at the University of Cambridge. and a UK Dementia Research Institute Professor.
Sir Hugh Reginald Brentnall Pelham, is a cell biologist who has contributed to our understanding of the body's response to rises in temperature through the synthesis of heat shock proteins. He served as director of the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) between 2006 and 2018.
Duncan T. Odom is a research group leader at the Cancer Research UK Cambridge Institute at the University of Cambridge. Previously he was as an associate faculty member at the Wellcome Trust Sanger Institute from 2011 to 2018.
Anne Jacqueline Ridley is professor of Cell Biology and Head of School for Cellular and Molecular Medicine at the University of Bristol. She was previously a professor at King's College London.
Neil Alexander Steven Brockdorff is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford. Brockdorff's research investigates gene and genome regulation in mammalian development. His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.