Carol Prives | |
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Education | BSc McGill University, Canada PhD McGill University, Canada Honorary Doctor of Sciences McGill University, Canada |
Alma mater | |
Known for | The characterization of p53, an important tumour suppressor protein frequently mutated in cancer. |
Awards | NIH MERIT Award (1996) Rosalind E. Franklin Award for Women in Science, National Cancer Institute (2009) ContentsPaul Janssen Prize in Biotechnology and Medicine (2010) AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship (2011) |
Scientific career | |
Institutions |
Professor Carol L. Prives FRS is the Da Costa Professor of Biological Sciences at Columbia University. [1] She is known for her work in the characterisation of p53, an important tumor suppressor protein frequently mutated in cancer.
Prives was educated in Canada, received her BSc and PhD [2] in 1966 [3] from McGill University, undertaking research in the lab of Juda Hirsch Quastel. [4] She pursued postdoctoral fellowships at Albert Einstein College of Medicine and the Weizmann Institute under the mentorship of Professor Michel Revel. after which she became a faculty member at the Weizmann Institute. [1] She received an honorary Doctor of Sciences degree from McGill University, her alma mater, on 29 May 2014 for her contributions to the understanding of p53. [5]
In 1995, she was appointed as the Da Costa Professor of Biology at Columbia University. [3] She was the chair of the Department of Biological Sciences from 2000 to 2004. [6]
Her early interest in the SV40 DNA tumour virus as a model for eukaryotic gene expression and oncogenic transformation led her to the study of p53. [7] Since the late 1980s, her lab has focused on the p53 tumour suppressor gene, one of the most frequently mutated in human cancers.
Prives has served as chair of the Experimental Virology and the Cell and Molecular Pathology study sections of the National Institutes of Health. She has been a member of the Scientific Advisory Boards of the Dana–Farber Cancer Institute, the Memorial Sloan Kettering Cancer Center, the Massachusetts General Cancer Center, the National Cancer Institute, [1] and the Weizmann Institute. [6] She was a member of the board of directors of the American Association for Cancer Research from 2004 to 2007. She also served on the Life Sciences jury for the Infosys Prize in 2010.
She is a member of the editorial boards of Cell , [8] Oncogene [9] and the Proceedings of the National Academy of Sciences . [10]
Alfred George Knudson, Jr. was an American physician and geneticist specializing in cancer genetics. Among his many contributions to the field was the formulation of the Knudson hypothesis in 1971, which explains the effects of mutation on carcinogenesis.
Karen Heather Vousden, CBE, FRS, FRSE, FMedSci is a British medical researcher. She is known for her work on the tumour suppressor protein, p53, and in particular her discovery of the important regulatory role of Mdm2, an attractive target for anti-cancer agents. From 2003 to 2016, she was the director of the Cancer Research UK Beatson Institute in Glasgow, UK, moving back to London in 2016 to take up the role of Chief Scientist at CRUK and Group Leader at the Francis Crick Institute.
Arnold Jay Levine, is an American molecular biologist. He was awarded the 1998 Louisa Gross Horwitz Prize for Biology or Biochemistry and was the first recipient of the Albany Medical Center Prize in Medicine and Biomedical Research in 2001 for his discovery of the tumor suppressor protein p53.
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Peter K. Vogt is an American molecular biologist, virologist and geneticist. His research focuses on retroviruses and viral and cellular oncogenes.
Jill Bargonetti is an American professor at the City University of New York with dual appointments at Hunter College and The Graduate Center. Her research is focused on tumor suppressor protein p53 and its role as an oncogene when it is mutated in breast cancer.
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Gregory James Hannon is a professor of molecular cancer biology and director of the Cancer Research UK Cambridge Institute at the University of Cambridge. He is a Fellow of Trinity College, Cambridge while also serving as a director of cancer genomics at the New York Genome Center and an adjunct professor at Cold Spring Harbor Laboratory.
Dafna Bar-Sagi is a cell biologist and cancer researcher at New York University School of Medicine. She is the Saul J. Farber Professor in the department of biochemistry and molecular pharmacology and the department of medicine and senior vice president and vice dean for science at NYU Langone Health. Bar-Sagi has been a member of scientific advisory boards, including the National Cancer Institute, Starr Cancer Consortium, and Pancreatic Cancer Action Network.
Guillermina 'Gigi' Lozano is an American geneticist. She is a professor at University of Texas MD Anderson Cancer Center. Lozano is recognised for her studies of the p53 tumour suppressor pathway, characterising the protein as a regulator of gene expression.
Eileen White is an American professor and scientist who currently serves as deputy director, chief scientific officer, and associate director for basic science at the Rutgers Cancer Institute of New Jersey. She is also the distinguished professor of molecular biology and biochemistry at Rutgers University. White was elected member of the National Academy of Sciences in 2021.
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