Evolution is the change in the heritable characteristics of biological populations over successive generations. It occurs when evolutionary processes such as natural selection and genetic drift act on genetic variation, resulting in certain characteristics becoming more or less common within a population over successive generations. The process of evolution has given rise to biodiversity at every level of biological organisation.
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA, which then may undergo error-prone repair, cause an error during other forms of repair, or cause an error during replication. Mutations may also result from substitution, insertion or deletion of segments of DNA due to mobile genetic elements.
Gene duplication is a major mechanism through which new genetic material is generated during molecular evolution. It can be defined as any duplication of a region of DNA that contains a gene. Gene duplications can arise as products of several types of errors in DNA replication and repair machinery as well as through fortuitous capture by selfish genetic elements. Common sources of gene duplications include ectopic recombination, retrotransposition event, aneuploidy, polyploidy, and replication slippage.
Tomoko Ohta is a Japanese scientist and Professor Emeritus of the National Institute of Genetics. Ohta works on population genetics/molecular evolution and is known for developing the nearly neutral theory of evolution.
Steranes constitute a class of tetracyclic triterpanes derived from steroids or sterols via diagenetic and catagenetic degradation, such as hydrogenation. They are found in sediments and sedimentary rocks in nature. Steranes are derivatives of gonane, the steroid nucleus which is also called "cyclopentanoperhydrophenanthrene". They have an androstane skeleton with a side chain at the C-17 carbon, constituting the scaffold of all sterols. Steranes are widely used as biomarkers for the presence of eukaryotes in past ecosystems because steroids are nearly exclusively produced by eukaryotes. In particular, cholestanes are diagenetic products of cholesterol in animals, while stigmastanes are diagenetic products of stigmasterols in algae and land plants. However, some bacteria are now known to produce sterols and it is inferred that the ultimate origin of sterol biosynthesis is in bacteria. Sterols are produced via protosterols that are direct cyclization compounds of squalene by the catalysis of oxidosqualene cyclase. All known sterols in eukaryotes are enzymatically extensively modified from protosterols, while organisms that only produce protosterols are not known. The oldest record of modified steranes are in sedimentary rocks deposited ca. 720–820 million years ago. In contrast, diagenetic products of protosterols are widely distributed in older Proterozoic rocks and imply the presence of extinct proto-eukaryotes and/or sterol-producing bacteria before the evolution of crown-group eukaryotes.
Paul Reinhard Schimmel is an American biophysical chemist and translational medicine pioneer.
David Jay Julius is an American physiologist and Nobel Prize laureate known for his work on molecular mechanisms of pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He is a professor at the University of California, San Francisco.
Diethard Tautz is a German biologist and geneticist, who is primarily concerned with the molecular basis of the evolution of mammals. Since 2006 he is director at the Max Planck Institute for Evolutionary Biology in Plön.
Peter D. Keightley is a British geneticist who is Professor of Evolutionary Genetics at the Institute of Evolutionary Biology in School of Biological Sciences at the University of Edinburgh.
Haplogroup HIJK, defined by the SNPs F929, M578, PF3494 and S6397, is a common Y-chromosome haplogroup. Like its parent macrohaplogroup GHIJK, Haplogroup HIJK and its subclades comprise the vast majority of the world's male population.
Richard Malcolm Marais a British researcher who was Director of the Cancer Research UK (CRUK) Manchester Institute and Professor of Molecular Oncology at the University of Manchester.
Jessica Polka is a biochemist and the Executive Director of ASAPbio, a non-profit initiative promoting innovation and transparency via preprints and open peer review. She was one of the organizers of a recent meeting they held on scholarly communication.
Kiyoshi Nagai was a Japanese structural biologist at the MRC Laboratory of Molecular Biology Cambridge, UK. He was known for his work on the mechanism of RNA splicing and structures of the spliceosome.
Csaba Pal is a Hungarian biologist at the Biological Research Centre (BRC) in Szeged Hungary. His laboratory is part of the Synthetic and Systems Biology Unit at BRC. His research is at the interface of evolution, antibiotic resistance and genome engineering and has published over 80 scientific publications in these areas.
Pangalloanserae is a clade of birds defined in a 2001 study by Jacques Gauthier and Kevin de Queiroz as "most inclusive clade containing Galloanserae but not Neoaves". It contains crown Galloanserae as well as all stem-galloanserans.
Max Born was a widely influential German physicist and mathematician who was awarded the 1954 Nobel Prize in Physics for his pivotal role in the development of quantum mechanics. Born won the prize primarily for his contributions to the statistical interpretation of the wave function, though he is known for his work in several areas of quantum mechanics as well as solid-state physics, optics, and special relativity. Born's entry in the Biographical Memoirs of Fellows of the Royal Society included thirty books and 330 papers.
Ervin Fodor is a British virologist of Hungarian origin born in Czechoslovakia. He is Professor of Virology holding the position of reader in experimental pathology in the Sir William Dunn School of Pathology at the University of Oxford. He is also a professorial fellow at Exeter College, Oxford.
Jay Fineberg is an Israeli physicist. He is a professor at The Racah Institute of Physics of the Hebrew University of Jerusalem. He is known for his work on various aspects of nonlinear physics, mainly in the fields of fracture and friction. He is an elected fellow of the American Physical Society and the Israel Physical Society.
Oliver Lawrence Phillips is a British ecologist who specializes in tropical forests and is currently Professor of Tropical Ecology in the School of Geography at the University of Leeds. He is noted for his work coordinating large-scale, collaborative research projects that study how humans have changed the world's tropical forests, and the implications for climate change.
Brandon Stuart Gaut is an American evolutionary biologist and geneticist who works as a Distinguished Professor of Ecology and Evolutionary Biology at the University of California, Irvine.
