Russ Altman

Last updated
Russ Biagio Altman
Russ B. Altman.jpg
Russ B. Altman in 2007
Born
Brooklyn, New York [1]
Alma mater Harvard College
Stanford University
Scientific career
Institutions Stanford University
Thesis Exclusion methods for the determination of protein structure from experimental data [2]  (1989)
Doctoral students Nicholas Tatonetti
Olga Troyanskaya
Soumya Raychaudhuri
External videos
Nuvola apps kaboodle.svg What really happens when you mix medications?, 14:41, TED talks [3]

Russ Biagio Altman is an American professor of bioengineering, genetics, medicine, and biomedical data science (and of computer science, by courtesy) and past chairman of the bioengineering department at Stanford University.

Contents

Education

Altman holds an A.B. from Harvard College in 1983, a Ph.D. in medical information sciences from Stanford in 1989 and M.D. from Stanford Medical School in 1990. [2] After his internship at Stanford, he became board certified in 1991 in internal medicine and in clinical informatics in 2014. After a year of post-doctoral research, he joined the faculty as assistant professor in 1992. He became full professor in 2004, and was chair of the department of bioengineering from 2007 to June 2012. [1] He currently is the Kenneth Fong Professor of Engineering at Stanford, and an advisor to the Chan Zuckerberg Biohub. As of 2018, Altman was a founding co-editor of the Annual Review of Biomedical Data Science . [4]

Research and career

His primary research interests are in the application of computing and informatics technologies to problems relevant to medicine. He is particularly interested in methods for understanding drug action at molecular, cellular, organism and population levels. His lab studies how human genetic variation impacts drug response, helping start the PharmGKB project in 2000. [5] Other work focuses on the analysis of biological molecules to understand the actions, interactions and adverse events of drugs, publishing a database called FEATURE in 2003. [6] [7] He helps lead an FDA-supported center for regulatory science and innovation (CERSI). [8] He chaired the Science Board advising the FDA Commissioner, serves on the NIH director’s advisory committee, and is co-chair of the IOM Drug Forum. He is an organizer of the annual Pacific Symposium on Biocomputing. He co-founded Personalis, Inc. in 2011 along with three other faculty members including Euan Ashley, Atul Butte, Michael Snyder and businessman John West. [9] In 2017, he started hosting a show on SiriusXM (Insight Channel 121) titled "The Future of Everything". [10] He is clinically active with a pharmacogenomics consultative service at Stanford Healthcare.

Awards and honors

Altman received the U.S. Presidential Early Career Award for Scientists and Engineers (1997) and a National Science Foundation CAREER Award (1996). He is a fellow of the American College of Physicians (ACP), the American College of Medical Informatics (ACMI), the American Institute for Medical and Biological Engineering (AIMBE), and the American Association for the Advancement of Science (AAAS). He is a member of the National Academy of Medicine (formerly the Institute of Medicine) of the National Academies. He was president (2000 to 2002), founding board member, and a Fellow of the International Society for Computational Biology (ISCB), and-president of the American Society for Clinical Pharmacology & Therapeutics (ASCPT) from March 2013 to 2014. [11]

He received the Stanford Medical School graduate teaching award in 2000, and mentorship award in 2014.

In 2018, Altman was awarded the ISCB Outstanding Contributions Award. [12]

Related Research Articles

<span class="mw-page-title-main">University of California, San Francisco</span> Public university in California, US

The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It conducts research and teaching in medical and biological sciences.

<span class="mw-page-title-main">Pharmacogenomics</span> Study of the role of the genome in drug response

Pharmacogenomics, often abbreviated "PGx," is the study of the role of the genome in drug response. Its name reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of a patient affects their response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response, by correlating DNA mutations with pharmacokinetic, pharmacodynamic, and/or immunogenic endpoints.

<span class="mw-page-title-main">CYP2D6</span> Human liver enzyme

Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.

Translational medicine develops the clinical practice applications of the basic science aspects of the biomedical sciences; that is, it translates basic science to applied science in medical practice. It is defined by the European Society for Translational Medicine as "an interdisciplinary branch of the biomedical field supported by three main pillars: benchside, bedside, and community". The goal of translational medicine is to combine disciplines, resources, expertise, and techniques within these pillars to promote enhancements in prevention, diagnosis, and therapies. Accordingly, translational medicine is a highly interdisciplinary field, the primary goal of which is to coalesce assets of various natures within the individual pillars in order to improve the global healthcare system significantly.

Edward ("Ted") Hance Shortliffe is a Canadian-born American biomedical informatician, physician, and computer scientist. Shortliffe is a pioneer in the use of artificial intelligence in medicine. He was the principal developer of the clinical expert system MYCIN, one of the first rule-based artificial intelligence expert systems, which obtained clinical data interactively from a physician user and was used to diagnose and recommend treatment for severe infections. While never used in practice, its performance was shown to be comparable to and sometimes more accurate than that of Stanford infectious disease faculty. This spurred the development of a wide range of activity in the development of rule-based expert systems, knowledge representation, belief nets and other areas, and its design greatly influenced the subsequent development of computing in medicine.

June Lee is an adjunct professor in the UCSF School of Medicine, biotech executive, and medical doctor with expertise in pulmonary, critical care medicine and translational research.

<span class="mw-page-title-main">International Society for Computational Biology</span> Scholarly society

The International Society for Computational Biology (ISCB) is a scholarly society for researchers in computational biology and bioinformatics. The society was founded in 1997 to provide a stable financial home for the Intelligent Systems for Molecular Biology (ISMB) conference and has grown to become a larger society working towards advancing understanding of living systems through computation and for communicating scientific advances worldwide.

<span class="mw-page-title-main">Olga Troyanskaya</span> American academic

Olga G. Troyanskaya is a Professor in the Department of Computer Science and the Lewis-Sigler Institute for Integrative Genomics at Princeton University and the Deputy Director for Genomics at the Flatiron Institute's Center for Computational Biology in NYC. She studies protein function and interactions in biological pathways by analyzing genomic data using computational tools.

<span class="mw-page-title-main">Atul Butte</span> American medical researcher

Atul J. Butte is a biomedical informatics researcher and biotechnology entrepreneur. He is currently the Priscilla Chan and Mark Zuckerberg Distinguished Professor at the University of California, San Francisco. Since April 2015, Butte has serves as inaugural director of UCSF's Bakar Computational Health Sciences Institute.

Translational bioinformatics (TBI) is a field that emerged in the 2010s to study health informatics, focused on the convergence of molecular bioinformatics, biostatistics, statistical genetics and clinical informatics. Its focus is on applying informatics methodology to the increasing amount of biomedical and genomic data to formulate knowledge and medical tools, which can be utilized by scientists, clinicians, and patients. Furthermore, it involves applying biomedical research to improve human health through the use of computer-based information system. TBI employs data mining and analyzing biomedical informatics in order to generate clinical knowledge for application. Clinical knowledge includes finding similarities in patient populations, interpreting biological information to suggest therapy treatments and predict health outcomes.

<span class="mw-page-title-main">Scott L. Delp</span>

Scott L. Delp is an American academic who is the James H. Clark Professor of Bioengineering and Mechanical Engineering at Stanford University. He is the Founding Chairman of the Department of Bioengineering at Stanford, the Director of the National Center for Simulation in Rehabilitation Research (NCSRR), Simbios, the NIH Center for Physics-Based Simulations of Biological Structures at Stanford., and the Mobilize Center, a data science research center focused on mobile health.

The Pharmacogenomics Knowledgebase (PharmGKB) is a publicly available, online knowledge base responsible for the aggregation, curation, integration and dissemination of knowledge regarding the impact of human genetic variation on drug response. It is funded by the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS), and is a partner of the NIH Pharmacogenomics Research Network (PGRN). It has been managed at Stanford University since its inception in 2000.

<span class="mw-page-title-main">Euan Ashley</span> American professor of medicine

Euan Angus Ashley is a Scottish physician, scientist, author, and founder based at Stanford University in California where he is Associate Dean in the School of Medicine and holds the Roger and Joelle Burnell Chair of Genomics and Precision Health. He is known for helping establish the field of medical genomics.

The UCSF Graduate Division is the graduate school of the University of California, San Francisco, and is located in San Francisco. It is recognized as one of the premier biomedical graduate schools in the United States. It offers 19 PhD programs, 11 MS programs, two certificates and a physical therapy program.

Kathleen M. Giacomini is a professor of bioengineering and therapeutic sciences at the University of California, San Francisco. Her work focuses on how genetics affects the efficacy of drugs. She is also the co-director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation for the department of Bioengineering at the University of California, San Francisco.

Xiaole Shirley Liu (刘小乐) is computational biologist, cancer researcher, and entrepreneur. She has been a Professor in the Department of Data Sciences at the Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health. She is now the co-founder and CEO of GV20 Therapeutics.

Pharmacogene Variation Consortium is an international group of experts that maintains a systematic nomenclature system for allelic variations of genes that affect the metabolism of drugs.

Teri E. Klein is an American professor of Biomedical Data Science and Medicine at Stanford University. She is known for her work on pharmacogenomics and computational biology.

<span class="mw-page-title-main">Matthias Schwab (pharmacologist)</span> German pharmacologist

Matthias Schwab is a German doctor and university lecturer. He is director of the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology located on the campus of the Robert-Bosch-Hospital in Stuttgart, an institution of the Robert Bosch Stiftung, and holder of the Chair of Clinical Pharmacology at the University of Tübingen as well as Medical Director of the Department of Clinical Pharmacology at the University Hospital Tübingen.

<span class="mw-page-title-main">Nicholas Tatonetti</span> American bioscientist and academic

Nicholas Pierino Tatonetti is an American bioscientist who is Vice Chair of Operations in the Department of Computational Biomedicine and Associate Director of Computational Oncology in the Cancer Center at Cedars-Sinai Medical Center in Los Angeles, California.

References

  1. 1 2 "Curriculum Vitae: Russ Biagio Altman, MD, PhD". CAP profile. Stanford School of Medicine. March 2015. Retrieved April 1, 2017.
  2. 1 2 Russ B. Altman (1989). Exclusion methods for the determination of protein structure from experimental data (phd). Stanford University.
  3. ↑ "What really happens when you mix medications?". TED (talks). 2 March 2016. Retrieved April 2, 2016.
  4. ↑ Altman, Russ B.; Levitt, Michael (2018). "What is Biomedical Data Science and do We Need an Annual Review of It?". Annual Review of Biomedical Data Science. 1: i–iii. doi: 10.1146/annurev-bd-01-041718-100001 .
  5. ↑ Klein TE, Chang JT, Cho MK, Easton KL, Fergerson R, Hewett M, Lin Z, Liu Y, Liu S, Oliver DE, Rubin DL, Shafa F, Stuart JM, Altman RB (2001). "Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base". The Pharmacogenomics Journal. 1 (3): 167–170. doi: 10.1038/sj.tpj.6500035 . PMID   11908751.
  6. ↑ Liang MP, Banatao DR, Klein TE, Brutlag DL, Altman RB (July 1, 2003). "WebFEATURE: an interactive web tool for identifying and visualizing functional sites on macromolecular structures". Nucleic Acids Research. 31 (13): 3324–7. doi:10.1093/nar/gkg553. PMC   168960 . PMID   12824318.
  7. ↑ "Citations and publications". WebFEATURE web site. Retrieved April 1, 2017.
  8. ↑ "Home | UCSF-Stanford Center of Excellence in Regulatory Science and Innovation (CERSI) | UCSF".
  9. ↑ "About Us: Pioneering Genome-Guided Medicine". Personalis web site. Retrieved April 1, 2017.
  10. ↑ "Stanford Radio" . Retrieved April 1, 2017.
  11. ↑ "ASCPT News". Clinical Pharmacology & Therapeutics. 93 (3): 222–227. December 18, 2012. doi:10.1038/clpt.2012.248. S2CID   221604509.
  12. ↑ "February 14, 2018: ISCB Congratulates the 2018 ISCB Award Winners!". www.iscb.org. Retrieved 15 February 2018.
Preceded by President of the
International Society for Computational Biology
2000 – 2002		Succeeded by
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.