An epigenome consists of a record of the chemical changes to the DNA and histone proteins of an organism; these changes can be passed down to an organism's offspring via transgenerational stranded epigenetic inheritance. Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome.
Eugene Wimberly "Gene" Myers, Jr. is an American computer scientist and bioinformatician, who is best known for contributing to the early development of the NCBI's BLAST tool for sequence analysis.
Computational epigenetics uses statistical methods and mathematical modelling in epigenetic research. Due to the recent explosion of epigenome datasets, computational methods play an increasing role in all areas of epigenetic research.
The ISCB Overton Prize is a computational biology prize awarded annually for outstanding accomplishment by a scientist in the early to mid stage of his or her career. Laureates have made significant contribution to the field of computational biology either through research, education, service, or a combination of the three.
Steven Elliot Brenner is a professor at the Department of Plant and Microbial Biology at the University of California Berkeley, Adjunct Professor at the Department of Bioengineering and Therapeutic Sciences at the University of California, and San Francisco Faculty Scientist, Physical Biosciences at the Lawrence Berkeley National Laboratory.
Christopher Boyce Burge is Professor of Biology and Biological Engineering at Massachusetts Institute of Technology.
Aviv Regev is a computational biologist and systems biologist and Executive Vice President and Head of Genentech Research and Early Development in Genentech/Roche. She is a core member at the Broad Institute of MIT and Harvard and professor at the Department of Biology of the Massachusetts Institute of Technology. Regev is a pioneer of single cell genomics and of computational and systems biology of gene regulatory circuits. She founded and leads the Human Cell Atlas project, together with Sarah Teichmann.
Alfonso Valencia is a Spanish biologist, ICREA Professor, current director of the Life Sciences department at Barcelona Supercomputing Center. and of Spanish National Bioinformatics Institute (INB-ISCIII). From 2015-2018, he was President of the International Society for Computational Biology. His research is focused on the study of biomedical systems with computational biology and bioinformatics approaches.
Dana Pe'er is currently the Chair and Professor in Computational and Systems Biology Program at Sloan Kettering Institute, and regarded as one of the leading researchers in computational systems biology. She was selected as a Howard Hughes Medical Institute (HHMI) Investigator in September, 2021. Previously, she was a professor at Columbia Department of Biological Sciences. Pe'er's research focuses on understanding the organization, function and evolution of molecular networks, particularly how genetic variations alter the regulatory network and how these genetic variations can cause cancer.
Margaret (“Peggy”) A. Goodell is an American scientist working in the field of stem cell research. Goodell is Chair of the Department of Molecular and Cellular Biology at Baylor College of Medicine, Director of the Stem Cell and Regenerative Medicine (STaR) Center, and a member of the National Academy of Medicine. She is best known for her discovery of a novel method to isolate adult stem cells.
Sarah Amalia Teichmann is a German scientist who is head of cellular genetics at the Wellcome Sanger Institute and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI). She serves as director of research in the Cavendish Laboratory, at the University of Cambridge and a senior research fellow at Churchill College, Cambridge.
The Computational Biology Department (CBD) is a division within the School of Computer Science at Carnegie Mellon University in Pittsburgh, Pennsylvania, United States. It is located in the Gates-Hillman Center. Established in 2007 by Robert F. Murphy as the Lane Center for Computational Biology with funding from Raymond J. Lane and Stephanie Lane, CBD became a department within the School of Computer Science in 2016.
Thomas Lengauer is a German computer scientist and computational biologist.
Janet Kelso is a South African computational biologist and Group leader of the Minerva Research Group for Bioinformatics at the Max Planck Institute for Evolutionary Anthropology. She is best known for her work comparing DNA from previous humans with those of the present.
Single cell epigenomics is the study of epigenomics in individual cells by single cell sequencing. Since 2013, methods have been created including whole-genome single-cell bisulfite sequencing to measure DNA methylation, whole-genome ChIP-sequencing to measure histone modifications, whole-genome ATAC-seq to measure chromatin accessibility and chromosome conformation capture.
Denise P. Barlow was a British geneticist who worked in the field of epigenomics. Barlow was an elected member of European Molecular Biology Organization (EMBO), an honorary professor of genetics at the University of Vienna and recipient of the Erwin Schrödinger Prize of the Austrian Academy of Sciences. In 1991, she discovered the first mammalian imprinted gene, IGF2R, which codes for the insulin-like growth factor.
Christophe Dessimoz is a Swiss National Science Foundation (SNSF) Professor at the University of Lausanne, Associate Professor at University College London and a group leader at the Swiss Institute of Bioinformatics. He was awarded the Overton Prize in 2019 for his contributions to computational biology. Starting in April 2022, he will be joint executive director of the SIB Swiss Institute of Bioinformatics, along with Ron Appel.
Judith Anne Blake is a computational biologist at the Jackson Laboratory and Professor of Mammalian Genetics.
Katherine Snowden Pollard is the Director of the Gladstone Institute of Data Science and Biotechnology and a Professor at the University of California, San Francisco (UCSF). She is a Chan Zuckerberg Biohub Investigator. She was awarded Fellowship of the International Society for Computational Biology in 2020 and the American Institute for Medical and Biological Engineering in 2021 for outstanding contributions to computational biology and bioinformatics.
Zhiping Weng is the Li Weibo Professor of biomedical research and chair of the program in integrative biology and bioinformatics at the University of Massachusetts Medical School. She was awarded Fellowship of the International Society for Computational Biology (ISCB) in 2020 for outstanding contributions to computational biology and bioinformatics.
