Anita Corbett

Anita Corbett
Born	Anita Hargrave Corbett
Alma mater	Colgate University (BS) Vanderbilt University (PhD)
Scientific career
Fields	mRNA processing Polyadenylation Gene expression Intellectual disability [1]
Institutions	Emory University
Thesis	Regulation of the catalytic cycle of topoisomerase II  (1992)
Doctoral advisor	Neil Osheroff  [ Wikidata ]
Website	biology.emory.edu/corbett

Anita Hargrave Corbett is an American biochemist who is the Samuel C. Dobbs Professor in the Department of Biology at Emory University. ^{[1] [2]} Her research investigates the molecular basis for disease, the regulation of protein import and mRNA export. She is a Fellow of the American Association for the Advancement of Science and the American Society for Biochemistry and Molecular Biology.

Early life and education

As a high school student, Corbett took part in the National Science Bowl. She has said that her high school chemistry teacher made her believe she could be a chemist, and encouraged her to take AP Chemistry.^{[ citation needed ]} She was an undergraduate student at Colgate University, ^[3] where she became interested in biochemistry, and studied the activation and inhibition of bovine carbonic anhydrase. ^[4] Corbett was a doctoral researcher at Vanderbilt University, ^[5] where she studied the regulation of topoisomerase II supervised by Neil Osheroff  [ Wikidata ]. ^[6]

Research and career

After her PhD, she moved to Harvard Medical School as a postdoctoral researcher with Pamela Silver. ^[7]

In 2003, Corbett was the first woman to be tenured in the Emory University School of Medicine. ^[5] Her research investigates the regulation of biological processes, including the import of proteins and export of mRNA. She studies these processes using model systems of yeast, Drosophila and laboratory mice. ^{[8] [9]} It is well understood that disease is linked to mutations in genes encoding structural RNA exosome subunits. ^[5] Corbett linked mutations in one particular subunit, EXOSC5, to poor clinical outcomes. ^[10] She has extensively investigated RNA-binding proteins, which are involved with various stages of gene expression. ^[11]

Awards and honors

• 2015 Eleanor Main Graduate Faculty Mentor Award ^[12]
• 2018 Nature Awards for Mentoring in Science ^[7]
• 2020 American Society for Biochemistry and Molecular Biology Mid-Career Leadership Award ^[5]
• 2022 Elected Fellow of the American Association for the Advancement of Science ^[13]
• 2022 Elected Fellow of the American Society for Biochemistry and Molecular Biology ^[14]
• 2022 RNA Society Award for Excellence in Inclusive Leadership ^[15]

Selected publications

• Allison Lange; Ryan E. Mills; Christopher J Lange; Murray Stewart; Scott E Devine; Anita H Corbett (14 December 2006). "Classical nuclear localization signals: definition, function, and interaction with importin alpha". Journal of Biological Chemistry . 282 (8): 5101–5105. doi: 10.1074/JBC.R600026200 . ISSN   0021-9258. PMC   4502416 . PMID   17170104. Wikidata   Q34591163.
• Debashish Ray; Hilal Kazan; Kate B Cook; et al. (1 July 2013). "A compendium of RNA-binding motifs for decoding gene regulation". Nature . 499 (7457): 172–177. doi:10.1038/NATURE12311. ISSN   1476-4687. PMC   3929597 . PMID   23846655. Wikidata   Q34357005.
• David S Goldfarb; Anita H Corbett; D Adam Mason; Michelle T Harreman; Stephen A. Adam (1 September 2004). "Importin alpha: a multipurpose nuclear-transport receptor". Trends in Cell Biology (in English and English). 14 (9): 505–514. doi:10.1016/J.TCB.2004.07.016. ISSN   0962-8924. PMID   15350979. Wikidata   Q35879618.

References

1. Anita Corbett publications indexed by Google Scholar
2. Anita Corbett publications from Europe PubMed Central
3. "Anita H. Corbett, PhD". biology.emory.edu. Retrieved 2023-05-02.
4. Rowlett, R S; Gargiulo, N J; Santoli, F A; Jackson, J M; Corbett, A H (1991-01-15). "Activation and inhibition of bovine carbonic anhydrase III by dianions". Journal of Biological Chemistry. 266 (2): 933–941. doi: 10.1016/S0021-9258(17)35263-8 . ISSN   0021-9258. PMID   1898739.
5. "Corbett goes the extra mile to support young scientists". asbmb.org. Retrieved 2023-05-02.
6. Corbett, Anita Hargrave (1992). Regulation of the catalytic cycle of topoisomerase II (PhD thesis). OCLC   30332920. ProQuest   303996778.
7. Anon (2019). "Nature Awards give mentors the recognition, funding, and 'street cred' they need". springernature.com. Retrieved 2023-05-02.
8. "Professor Anita H. Corbett". rnasociety.org. Retrieved 2023-05-02.
9. Corbett, Anita H. (2015-04-01). "A long and winding road to the RNA world". RNA. 21 (4): 590–591. doi:10.1261/rna.049841.115. ISSN   1355-8382. PMC   4371294 . PMID   25780152.
10. Slavotinek, Anne; Misceo, Doriana; Htun, Stephanie; Mathisen, Linda; Frengen, Eirik; Foreman, Michelle; Hurtig, Jennifer E.; Enyenihi, Liz; Sterrett, Maria C.; Leung, Sara W.; Schneidman-Duhovny, Dina; Estrada-Veras, Juvianee; Duncan, Jacque L.; Haaxma, Charlotte A.; Kamsteeg, Erik-Jan (2020-08-03). "Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness". Human Molecular Genetics. 29 (13): 2218–2239. doi:10.1093/hmg/ddaa108. ISSN   1460-2083. PMC   7399534 . PMID   32504085.
11. "Anita Corbett". biology.emory.edu. Retrieved 2023-05-02.
12. "Laney Graduate School announces Eleanor Main Graduate Mentor Awards | Emory University | Atlanta GA". news.emory.edu. Retrieved 2023-05-02.
13. "Emory faculty named 2022 fellows of the American Association for the Advancement of Science | Emory University | Atlanta GA". news.emory.edu. Retrieved 2023-05-02.
14. "2022 ASBMB fellows named". asbmb.org. Retrieved 2023-05-02.
15. "2022 RNA Society Award for Excellence in Inclusive Leadership". rnasociety.org. Retrieved 2023-05-02.