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Ann Arvin | |
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| Born | 1945 (age 76–77) |
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Ann M. Arvin (born 1945) is a pediatrician and professor of Pediatrics and Microbiology/Immunology at Stanford University. Arvin is a specialist of the Varicella zoster virus (VZV) and a prominent national figure in health. Arvin is currently the chief of the infectious diseases division of pediatrics at the Lucile Packard Children's Hospital, [1] as well as the former Stanford's vice provost and dean of research. [2] [3]
Ann Arvin received her undergraduate degree in Philosophy from Brown University in 1966. [4] [2] She earned her M.A. in Philosophy from Brandeis University. [5] Arvin graduated from the University of Pennsylvania's medical school in 1972, [2] completed her pediatric residency at UCSF in 1975 and her postdoctoral fellowship at Stanford University in 1978. [4]
Ann Arvin has contributed to multiple national committees and boards. Arvin was elected to the Institute of Medicine (IOM), part of the National Academy of Sciences in 2003. [1] [2] She was one of the committee members for the 1999 Institute of Medicine Committee on the Assessment of Future Scientific Needs for Live Variola Virus [6] [7] and the chair of the 2009 IOM. [8] [ citation needed ] She also served on the U.S. Food and Drug Administration (FDA) Vaccines and Related Biological Products Advisory Committee, the NIH Collaborative Antiviral Study Group, the World Health Organization Committee on Research Related to Measles and Measles Vaccine, and the Council of the National Institute of Allergy and Infectious Disease. [9] Arvin is also a member of the Council of the American Society of Virology, the Thrasher Foundation Advisory Board, National Vaccine Advisory Committee, which advises the Secretary of the Department of Health and Human Services. [8]
Ann Arvin's research surrounds infectious diseases like Varicella Zoster virus (VZV), "focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in humans and in SCID mouse models of VZV cell tropisms in vivo." [10] Her research also surrounds T-cell response and immunity in children and the immunocompromised. [11]
She was the editor of several books in pediatrics and virology field, such as Nelson Textbook Of Pediatrics: Multi User", "Current Topics in Microbiology and Immunology: Varicella-zoster Virus", "Nelson Essentials of Pediatrics", "Varicella-zoster Virus: Virology and clinical management", "Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis", "Immunity to and Prevention of Herpes Zoster", and "Live Variola Virus: Considerations for Continuing Research".[ citation needed ]
Arvin has received several awards and honors for her research, such as the E. Mead Johnson Award for Research in Pediatrics (1992), [12] the John F. Enders Distinguished Lecture in Medical Virology (2002), [13] the Distinguished Graduate Award for 2010 from the University of Pennsylvania School of Medicine, [14] and Stanford University School of Medicine's Dean's Medal (2016). [15]
Cytomegalovirus (CMV) is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Humans and monkeys serve as natural hosts. The 11 species in this genus include human betaherpesvirus 5, which is the species that infects humans. Diseases associated with HHV-5 include mononucleosis and pneumonia. In the medical literature, most mentions of CMV without further specification refer implicitly to human CMV. Human CMV is the most studied of all cytomegaloviruses.
Varicella-zoster virus (VZV), also known as human herpesvirus 3 or Human alphaherpesvirus 3 (taxonomically), is one of nine known herpes viruses that can infect humans. It causes chickenpox (varicella) commonly affecting children and young adults, and shingles in adults but rarely in children. VZV infections are species-specific to humans, but the virus can survive in external environments for a few hours.
Pox may refer to:
Shingles, also known as zoster or herpes zoster, is a viral disease characterized by a painful skin rash with blisters in a localized area. Typically the rash occurs in a single, wide mark either on the left or right side of the body or face. Two to four days before the rash occurs there may be tingling or local pain in the area. Otherwise, there are typically few symptoms though some people may have fever or headache, or feel tired. The rash usually heals within two to four weeks; however, some people develop ongoing nerve pain which can last for months or years, a condition called postherpetic neuralgia (PHN). In those with poor immune function the rash may occur widely. If the rash involves the eye, vision loss may occur.
Valaciclovir, also spelled valacyclovir, is an antiviral medication used to treat outbreaks of herpes simplex or herpes zoster (shingles). It is also used to prevent cytomegalovirus following a kidney transplant in high risk cases. It is taken by mouth.
Thomas Huckle Weller was an American virologist. He, John Franklin Enders and Frederick Chapman Robbins were awarded a Nobel Prize in Physiology or Medicine in 1954 for showing how to cultivate poliomyelitis viruses in a test tube, using a combination of human embryonic skin and muscle tissue.
Stanley Alan Plotkin is an American physician who works as a consultant to vaccine manufacturers, such as Sanofi Pasteur, as well as biotechnology firms, non-profits and governments. In the 1960s, he played a pivotal role in discovery of a vaccine against rubella virus while working at Wistar Institute in Philadelphia. Plotkin was a member of Wistar’s active research faculty from 1960 to 1991. Today, in addition to his emeritus appointment at Wistar, he is emeritus professor of Pediatrics at the University of Pennsylvania. His book, Vaccines, is the standard reference on the subject. He is an editor with Clinical and Vaccine Immunology, which is published by the American Society for Microbiology in Washington, D.C.
Herpesviridae is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ἕρπειν, referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster (shingles). In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established Herpesvirus as a genus with 23 viruses among four groups. As of 2020, 115 species are recognized, all but one of which are in one of the three subfamilies. Herpesviruses can cause both latent and lytic infections.
B-virus, Herpesvirus simiae, or Herpes virus B is the Simplexvirus infecting macaque monkeys. B virus is very similar to HSV-1, and as such, this neurotropic virus is not found in the blood.
Varicella vaccine, also known as chickenpox vaccine, is a vaccine that protects against chickenpox. One dose of vaccine prevents 95% of moderate disease and 100% of severe disease. Two doses of vaccine are more effective than one. If given to those who are not immune within five days of exposure to chickenpox it prevents most cases of disease. Vaccinating a large portion of the population also protects those who are not vaccinated. It is given by injection just under the skin. Another vaccine, known as zoster vaccine, is used to prevent diseases caused by the same virus - the varicella zoster virus.
Sorivudine (INN), is a nucleoside analogue antiviral drug, marketed under trade names such as Usevir and Brovavir (BMS). It is used for the treatment of varicella zoster virus infections.
Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with varicella zoster virus (VZV). The disease results in a characteristic skin rash that forms small, itchy blisters, which eventually scab over. It usually starts on the chest, back, and face. It then spreads to the rest of the body. The rash and other symptoms, such as fever, tiredness, and headaches, usually last five to seven days. Complications may occasionally include pneumonia, inflammation of the brain, and bacterial skin infections. The disease is usually more severe in adults than in children.
Jane Aronson, D.O. is an osteopathic physician, with expertise in pediatric infectious diseases and adoption medicine.
Human betaherpesvirus 7 (HHV-7) is one of nine known members of the Herpesviridae family that infects humans. HHV-7 is a member of Betaherpesvirinae, a subfamily of the Herpesviridae that also includes HHV-6 and Cytomegalovirus. HHV-7 often acts together with HHV-6, and the viruses together are sometimes referred to by their genus, Roseolovirus. HHV-7 was first isolated in 1990 from CD4+ T cells taken from peripheral blood lymphocytes.
Samuel L. Katz is an American pediatrician and virologist whose career has been devoted to infectious disease research, focusing principally on vaccine research and development. Katz is currently the Wilburt Cornell Davison Professor and Chairman Emeritus of Pediatrics at Duke University.
Deborah Persaud is a Guyanese-born American virologist who primarily works on HIV/AIDS at Johns Hopkins Children's Center.
Human Herpes Viruses, also known as HHVs, are part of a family of DNA viruses that cause several diseases in humans. One of the most notable functions of this virus family is their ability to enter a latent phase and lay dormant within animals for extended periods of time. The mechanism that controls this is very complex because expression of viral proteins during latency is decreased a great deal, meaning that the virus must have transcription of its genes repressed. There are many factors and mechanisms that control this process and epigenetics is one way this is accomplished. Epigenetics refers to persistent changes in expression patterns that are not caused by changes to the DNA sequence. This happens through mechanisms such as methylation and acetylation of histones, DNA methylation, and non-coding RNAs (ncRNA). Altering the acetylation of histones creates changes in expression by changing the binding affinity of histones to DNA, making it harder or easier for transcription machinery to access the DNA. Methyl and acetyl groups can also act as binding sites for transcription factors and enzymes that further modify histones or alter the DNA itself.
Stephen E. Straus was an American physician, immunologist, virologist and science administrator. He is particularly known for his research into human herpesviruses and chronic fatigue syndrome, and for his discovery of the autoimmune lymphoproliferative syndrome genetic disorder. He headed the Laboratory of Clinical Investigation of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), and served as the founding director of the NIH's National Center for Complementary and Alternative Medicine.
Caprine alphaherpesvirus 1 (CpHV-1) is a species of virus known to infect goats worldwide. It has been shown to produce systemic and respiratory symptoms in kids and to cause abortions in adult goats.
Judith Breuer is a British virologist who is Professor of Virology and Director of the Pathogen Genomics Unit at University College London. She was elected a Fellow of the Academy of Medical Sciences in 2019. Breuer is part of the United Kingdom genome sequencing team that looks to map the spread of the coronavirus disease 2019.
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