Christopher John Nowinski is an American neuroscientist, author and retired professional wrestler. After extensively researching concussions in American football, Nowinski co-founded the Concussion Legacy Foundation, where he is currently CEO and co-founded Boston University's CTE Center. As a professional wrestler, he is best known for his tenure with World Wrestling Entertainment (WWE) under the ring name Chris Harvard and later under his real name.
Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology, but work closely with the clinical disciplines of neurology, and neurosurgery, which often depend on neuropathology for a diagnosis. Neuropathology also relates to forensic pathology because brain disease or brain injury can be related to cause of death. Neuropathology should not be confused with neuropathy, which refers to disorders of the nerves themselves rather than the tissues. In neuropathology, the branches of the specializations of nervous system as well as the tissues come together into one field of study.
Tauopathy belongs to a class of neurodegenerative diseases involving the aggregation of tau protein into neurofibrillary or gliofibrillary tangles in the human brain. Tangles are formed by hyperphosphorylation of the microtubule protein known as tau, causing the protein to dissociate from microtubules and form insoluble aggregates. The mechanism of tangle formation is not well understood, and whether tangles are a primary cause of Alzheimer's disease or play a peripheral role is unknown.
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repeated trauma to the head. The encephalopathy symptoms can include behavioral problems, mood problems, and problems with thinking. The disease often gets worse over time and can result in dementia.
Paul Kevin Turner was a professional American football fullback. He played eight seasons in the National Football League (NFL) for the New England Patriots and Philadelphia Eagles. Turner died after a multi-year battle with amyotrophic lateral sclerosis (ALS), which had been triggered by chronic traumatic encephalopathy (CTE).
Steven T. DeKosky is the Aerts-Cosper Professor of Alzheimer's Research at the University of Florida (UF) College of Medicine, deputy director of UF’s Evelyn F. and William L. McKnight Brain Institute (MBI) and associate director of the 1Florida Alzheimer’s Disease Research Center.
John Quinn Trojanowski was an American academic research neuroscientist specializing in neurodegeneration. He and his partner, Virginia Man-Yee Lee, MBA, Ph.D., are noted for identifying the roles of three proteins in neurodegenerative diseases: tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease, and TDP-43 in Amyotrophic Lateral Sclerosis (ALS) and frontotemporal degeneration.
Samuel E. Gandy, is a neurologist, cell biologist, Alzheimer's disease (AD) researcher and expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer's. His team discovered the first drugs that could lower the formation of amyloid.
Sandra Bond Chapman is a cognitive neuroscientist, founder and chief director of the Center for Brain Health, Dee Wyly Distinguished Professor in Brain Health, and a professor in the School of Behavioral and Brain Sciences at The University of Texas at Dallas.
Dr. Bennet Ifeakandu Omalu is a Nigerian and American physician, forensic pathologist and neuropathologist who was the first to discover and publish findings on chronic traumatic encephalopathy (CTE) in American football players while working at the Allegheny County coroner's office in Pittsburgh. He later became the chief medical examiner for San Joaquin County, California, and is a professor at the University of California, Davis, department of medical pathology and laboratory medicine. He is currently the President and Medical Director of Bennet Omalu Pathology.
Concussions and play-related head blows in American football have been shown to be the cause of chronic traumatic encephalopathy (CTE), which has led to player deaths and other debilitating symptoms after retirement, including memory loss, depression, anxiety, headaches, stress, and sleep disturbances.
Virginia Man-Yee Lee is a Chinese-born American biochemist and neuroscientist who specializes in the research of Alzheimer's disease. She is the current John H. Ware 3rd Endowed Professor in Alzheimer's Research at the Department of Pathology and Laboratory Medicine, and the director of the Center for Neurodegenerative Disease Research and co-director of the Marian S. Ware Alzheimer Drug Discovery Program at the Perelman School of Medicine, University of Pennsylvania. She received the 2020 Breakthrough Prize in Life Sciences.
Barry Festoff is a board-certified neurologist, Professor of Neurology at the University of Kansas Medical Center and the founder of pHLOGISTIX, a neurodiagnostic and therapeutic biotech company.
The Boston University CTE Center is an independently run medical research lab located at the Boston University School of Medicine. The Center focuses on research related to the long-term effects of brain trauma and degenerative brain diseases, specializing in the diagnosis and analysis of chronic traumatic encephalopathy (CTE). According to researchers at Boston University, CTE is a brain disease involving progressive neurological deterioration common in athletes, military personnel, and others who have a history of brain trauma. The disease is primarily caused by repeated blows to the head, some of which result in concussions or sub-concussive symptoms.
Robert A. Stern is professor of Neurology, Neurosurgery, and Anatomy & Neurobiology at Boston University School of Medicine, where he is also director of clinical research for the BU Chronic Traumatic Encephalopathy (CTE) Center. From 2010 to 2019, he was the director of the Clinical Core of the BU Alzheimer's Disease Center.
Most documented cases of chronic traumatic encephalopathy have occurred in athletes involved in contact sports such as boxing, American football, wrestling, ice hockey, mixed martial arts, rugby and soccer. Other risk factors include being in the military, prior domestic violence, and repeated banging of the head. The exact amount of trauma required for the condition to occur is unknown. Below is a list of notable cases of CTE in sports.
Donald L. Price (1935-2023) was an American neuropathologist and professor at the Johns Hopkins School of Medicine. His research aimed to understand the molecular basis of neurodegenerative diseases, particularly Alzheimer’s disease. Price received a number of awards for his work and served as the President of both the American Association of Neuropathologists and the Society for Neuroscience.
The Australian Sports Brain Bank is a medical research laboratory, a part of the neuropathology department of the Royal Prince Alfred Hospital (RPA) in Sydney. It is headed by neuropathologist Associate Professor Michael Buckland.
Daniel H. Daneshvar is an American neuroscientist, brain injury physician, and physiatrist. He is known for his academic work in traumatic brain injury and the long-term consequences of repetitive head impacts, including chronic traumatic encephalopathy (CTE). He also founded Team Up Against Concussions, the first scientifically validated concussion education program for children. He is the Director of the Institute for Brain Research and Innovation at TeachAids, which created CrashCourse, a virtual-reality or video based concussion education program.
Andrew E. Budson is an American neurologist, academic and researcher. He is a Professor of Neurology at Boston University School of Medicine, Lecturer in Neurology at Harvard Medical School, Chief of Cognitive and Behavioral Neurology and Associate Chief of Staff for Education at the Veterans Affairs (VA) Boston Healthcare System, where he also serves as a Director of the Center for Translational Cognitive Neuroscience. He is Associate Director and Outreach, Recruitment, and Engagement Core Leader at the Boston University Alzheimer’s Disease Research Center.
