Antonello Bonci

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Antonello Bonci
Drbonci2021.jpg
Alma mater Università Cattolica del Sacro Cuore (MD)
Scientific career
Fields Neuropsychopharmacology
Institutions University of California, San Francisco
National Institute on Drug Abuse

Antonello Bonci is an Italian-American neurologist and a neuropsychopharmacologist specialized in the long-term effects of drug exposure on the brain. In August 2019, he became president of Global Institutes on Addictions Miami. Bonci was previously the scientific director of the National Institute on Drug Abuse and a professor at the University of California, San Francisco.

Contents

Education

In 1985, Bonci went to Medical School at the Università Cattolica del Sacro Cuore, where he graduated cum laude in 1991. In that same year, he started a Residency in Neurology at the University of Rome Tor Vergata where he graduated cum laude in 1995. [1]

Career

Bonci became assistant professor in Residence at the University of California, San Francisco in 1999. He became Associate Professor in Residence in 2004, and Professor in Residence in 2007. When he left in 2010, Bonci was Professor in Residence in the Department of Neurology at the University of California, San Francisco (UCSF), the Howard J. Weinberg Endowed Chair in Addiction Research, and the Associate Director for Extramural Affairs at the Ernest Gallo Clinic and Research Center. In 2010, he was appointed as the Scientific Director of National Institute on Drug Abuse (NIDA). [2] Bonci resigned from his position in August 2019 after a sexual misconduct probe was opened against him for allegedly "sexual targetting" a trainee as well as directing resources to another trainee with whom he had an intimate relationship. [3] [4] [5]

Bonci is currently the President and Chief Scientific Officer at GIA Miami and Vita Recovery.

Research

Bonci is known for his studies on the long-term effects of drug exposure on the brain. [6] [7] Bonci's laboratory, in collaboration with Robert Malenka, was the first to demonstrate that drugs of abuse, such as cocaine, modify the strength of the connections between neurons. [8] This finding cast a new light on the phenomenon of drug addiction, as a process where maladaptive learning plays a role. [9] Subsequent studies have combined electrophysiological, optogenetic, molecular, and behavioral techniques to determine the long-term effects that are produced by chronic exposure to stress, cocaine or ethanol, with the goal of creating novel therapeutic avenues to decrease the devastating effects of these conditions. [10] [11] In 2013, a study led by Billy T. Chen, [12] provided rationale for the use of non-invasive brain stimulation, such as repeated Transcranial Magnetic Stimulation, in patients with cocaine use disorders. Clinical studies have indeed shown the potential of such technology in the treatment of cocaine use disorders.; [13] [14] [15] [16] In Europe, publications by Dr. Bonci and collaborators have been used by the TMS company Mag Venture to obtain the European CE approval for treatment of addiction. [17]

Publications (non-exhaustive list)

Awards and honors

References

  1. ↑ "Antonello Bonci, M.D. Scientific Director - Principal Investigators - The Intramural Research Program of the National Institute on Drug Abuse". 2014-02-01. Archived from the original on 2014-02-01. Retrieved 2020-09-10.
  2. ↑ "Leading Addiction Researcher Antonello Bonci joins NIDA to lead Intramural Research Program". 26 August 2015. Archived from the original on August 5, 2010.PD-icon.svg This article incorporates text from this source, which is in the public domain .
  3. ↑ Wadman, Meredith (5 November 2019). "Science chief at NIH drug abuse institute resigned after sexual misconduct probe". Science . Retrieved 14 February 2023.
  4. ↑ "ANTONELLO BONCI". Academic Sexual Misconduct Database. Retrieved 14 February 2023.
  5. ↑ Neote, Sarina (9 October 2020). "Survey: 1 in 5 NIH workers were sexually harassed in past year". ASBMB Today. Retrieved 14 February 2023.
  6. ↑ "Laser Light Zaps Away Cocaine Addiction". 3 April 2013.
  7. ↑ "Zap a cocaine addiction with lasers?". CBS News . 4 April 2013.
  8. ↑ Ungless, Mark A.; Whistler, Jennifer L.; Malenka, Robert C.; Bonci, Antonello (2001). "Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons". Nature. 411 (6837): 583–7. Bibcode:2001Natur.411..583U. doi:10.1038/35079077. PMID   11385572. S2CID   4311436.
  9. ↑ Bowers, M. Scott; Chen, Billy T.; Bonci, Antonello (2010). "AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future". Neuron. 67 (1): 11–24. doi:10.1016/j.neuron.2010.06.004. PMC   2904302 . PMID   20624588.
  10. ↑ Hopf, F. W.; Seif, T.; Bonci, A. (2011). "The SK channel as a novel target for treating alcohol use disorders". Channels (Austin, Tex.). 5 (4): 289–92. doi: 10.4161/chan.5.4.16577 . PMID   21712648.
  11. ↑ Pignatelli, M.; Tejeda, H. A.; Barker, D. J.; Bontempi, L.; Wu, J.; Lopez, A.; Palma Ribeiro, S.; Lucantonio, F.; Parise, E. M.; Torres-Berrio, A.; Alvarez-Bagnarol, Y.; Marino RAM; Cai, Z. L.; Xue, M.; Morales, M.; Tamminga, C. A.; Nestler, E. J.; Bonci, A. (2020). "Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice". Molecular Psychiatry. 26 (6): 1860–1879. doi: 10.1038/s41380-020-0686-8 . PMC   7735389 . PMID   32161361.
  12. ↑ Chen, B. T.; Yau, H. J.; Hatch, C.; Kusumoto-Yoshida, I.; Cho, S. L.; Hopf, F. W.; Bonci, A. (2013). "Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking". Nature. 496 (7445): 359–62. Bibcode:2013Natur.496..359C. doi:10.1038/nature12024. PMID   23552889. S2CID   4397137.
  13. ↑ Terraneo, A.; Leggio, L.; Saladini, M.; Ermani, M.; Bonci, A.; Gallimberti, L. (2016). "Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study". European Neuropsychopharmacology. 26 (1): 37–44. doi: 10.1016/j.euroneuro.2015.11.011 . PMC   9379076 . PMID   26655188.
  14. ↑ Madeo, G.; Terraneo, A.; Cardullo, S.; Gómez Pérez, L. J.; Cellini, N.; Sarlo, M.; Bonci, A.; Gallimberti, L. (2020). "Long-Term Outcome of Repetitive Transcranial Magnetic Stimulation in a Large Cohort of Patients with Cocaine-Use Disorder: An Observational Study". Frontiers in Psychiatry. 11 158. doi: 10.3389/fpsyt.2020.00158 . PMC   7059304 . PMID   32180745.
  15. ↑ Pettorruso, M.; Spagnolo, P. A.; Leggio, L.; Janiri, L.; Di Giannantonio, M.; Gallimberti, L.; Bonci, A.; Martinotti, G. (2018). "Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex may improve symptoms of anhedonia in individuals with cocaine use disorder: A pilot study". Brain Stimulation. 11 (5): 1195–1197. doi:10.1016/j.brs.2018.06.001. PMID   29885861. S2CID   47010124.
  16. ↑ Ekhtiari, H.; Tavakoli, H.; Addolorato, G.; Baeken, C.; Bonci, A.; Campanella, S.; Castelo-Branco, L.; Challet-Bouju, G.; Clark, V. P.; Claus, E.; Dannon, P. N.; Del Felice, A.; Den Uyl, T.; Diana, M.; Di Giannantonio, M.; Fedota, J. R.; Fitzgerald, P.; Gallimberti, L.; Grall-Bronnec, M.; Herremans, S. C.; Herrmann, M. J.; Jamil, A.; Khedr, E.; Kouimtsidis, C.; Kozak, K.; Krupitsky, E.; Lamm, C.; Lechner, W. V.; Madeo, G.; et al. (2019). "Transcranial electrical and magnetic stimulation (TES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead". Neuroscience and Biobehavioral Reviews. 104: 118–140. doi:10.1016/j.neubiorev.2019.06.007. hdl: 1765/118113 . PMC   7293143 . PMID   31271802.
  17. ↑ "PRESS RELEASE: Addiction, OCD & Comorbid Anxiety".
  18. ↑ "Bulletin Board". May 2005.
  19. ↑ "Daniel H. Efron Research Previous Award Winners". ACNP. Retrieved 2022-08-24.
  20. ↑ "PrimiDieci Society I Global Leaders Network I Ten Best".
  21. ↑ "National Academy of Medicine Elects 80 New Members". 17 October 2016.
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