 | |
| Names | |
|---|---|
| Preferred IUPAC name (4R,5S)-4,5-Dimethyl-4,5-bis[(3,4,6-trimethoxy-2-methylphenyl)ethynyl]-1,3-dioxolan-2-one | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
PubChem CID | |
| |
| |
| Properties | |
| C29H32O9 | |
| Molar mass | 524.566 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Antrodioxolanone is an anti-inflammatory isolated from Antrodia camphorata . [1]
Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain, decreases fever, prevents blood clots, and in higher doses, decreases inflammation. Side effects depend on the specific drug but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack, and kidney disease.
Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair.
Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It is taken by mouth, rectally in a suppository, used by injection, or applied to the skin. Improvements in pain last for as much as eight hours. It is also available in combination with misoprostol in an effort to decrease stomach problems.
Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, and fever. It is taken orally. It is available in immediate and delayed release formulations. Onset of effects is within an hour and last for up to twelve hours.
Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system to block pain signaling to the brain.
Oxaprozin, also known as oxaprozinum, is a nonsteroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.
Ajulemic acid (AB-III-56, HU-239, IP-751, CPL 7075, CT-3, JBT-101, Anabasum, Resunab) is a synthetic cannabinoid derivative of the THC metabolite 11-nor-9-carboxy-THC that shows anti-fibrotic and anti-inflammatory effects in pre-clinical studies without causing a subjective "high". It is being developed for the treatment of inflammatory and fibrotic conditions such as systemic sclerosis, dermatomyositis and cystic fibrosis. It does not share the anti-emetic effects of some other cannabinoids, but may be useful for treating chronic inflammatory conditions where inflammation fails to resolve. Side effects include dry mouth, tiredness, and dizziness. The mechanism of action is through activation of the CB2 receptor leading to production of specialized proresolving eicosanoids such as lipoxin A4 and Prostaglandin J2. Studies in animals at doses up to 40 mg/kg show minimal psychoactivity of ajulemic acid, compared to that produced by tetrahydrocannabinol. A composition of ajulemic acid named Lenabasum (formerly Anabasum, Resunab) is being developed by Corbus Pharmaceuticals (formerly JB Therapeutics) for the treatment of orphan chronic life-threatening inflammatory diseases.
Meclofenamic acid is a drug used for joint, muscular pain, arthritis and dysmenorrhea. It is a member of the anthranilic acid derivatives class of NSAID drugs and was approved by the FDA in 1980. Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.
Dexibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).
Salsalate is a medication that belongs to the salicylate and nonsteroidal anti-inflammatory drug (NSAID) classes.
Antrodia is a genus of fungi in the family Fomitopsidaceae. Antrodia species have fruit bodies that typically resupinate, with the hymenium exposed to the outside; the edges may be turned so as to form narrow brackets. Most species are found in temperate and boreal forests, and cause brown rot.
3-Methyl-3-octanol (systematically named 3-methyloctan-3-ol) is an organic compound with the chemical formula CH3(CH2)4C(CH3)(CH2CH3)OH (also written as C
9H
20O). This simple tertiary alcohol is a clear colourless liquid under standard conditions, and is tasteless.
Antrodia serialiformis is a species of polypore fungus in the family Fomitopsidaceae. The fungus is resupinate, consisting of a fertile spore-bearing pore surface lying flat on the underside of decaying wood, although one or more fan-shaped overlapping caps may also be formed. Although quite common in the eastern United States, it was not recognized as a distinct species until 2009, owing to its resemblance to the closely related Antrodia serialis. Differences in ecology, spore size, and DNA sequences distinguish the two lookalikes.
Antrodia cinnamomea is a fungus species, also known as AC fungus, or AC mushroom. It causes brown heart rot of aromatic tree Cinnamomum kanehirai. It is used in Taiwan medicine as a supposed remedy for cancer, hypertension, and hangover. Annual market is worth over $100 million (US) in Taiwan alone. Recently, the 32.15 Mb genome containing 9,254 genes was sequenced.
Antcin B is a steroid isolated from the mushroom Antrodia camphorata.
Zhankuic acids are sterols isolated from Taiwanofungus camphoratus. Zhankuic acid C possesses anti-inflammatory properties owing to its role as a selective TLR4/MD-2 antagonist.
Antrocamphin B is a bioactive isolate of Taiwanofungus camphoratus. Antrocamphin B is a congener of antrocamphin A.
A drug class is a set of medications and other compounds that have similar chemical structures, the same mechanism of action, a related mode of action, and/or are used to treat the same disease.
Zaltoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used as an analgesic, antipyretic, and anti-inflammatory agent. It is a selective COX-2 inhibitor and also inhibits bradykinin-induced pain responses without blocking bradykinin receptors.
Pluchea camphorata, known as camphorweed or marsh-fleabane, is a small flowering herbaceous annual plant of the family Asteraceae.
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