Arndt von Haeseler | |
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Born | Bremen [1] | 28 February 1959
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Thesis | Rekonstruktion phylogenetischer Bäume mit Hilfe von Varianten der Vier-Punkt-Bedingung [2] (1988) |
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Website | www |
Arndt von Haeseler (born 28 February 1959) is a German bioinformatician and evolutionary biologist. He is the scientific director of the Max F. Perutz Laboratories at the Vienna Biocenter and a professor of bioinformatics at the University of Vienna and the Medical University of Vienna.
Arndt von Haeseler obtained a doctorate in mathematics from the University of Bielefeld in 1988 under the supervision of Andreas Dress and Hans-Georg Carstens. [1] [2] He habilitated in 1994 at the Department of Zoology of the University of Munich, [1] where he remained as a lecturer until 1998. [3]
From 1998 until 2001, von Haeseler was a group leader at the Max Planck Institute for Evolutionary Anthropology in Leipzig. [3] From 2001 until 2005, he was professor of bioinformatics at the University of Düsseldorf. [1] He was a group leader in bioinformatics at Forschungszentrum Jülich. [3] In 2005, he joined the Max F. Perutz Laboratories (MFPL) in Vienna, where he leads the Center for Integrative Bioinformatics Vienna (CIBIV). [1] He is a professor of bioinformatics at the University of Vienna and the Medical University of Vienna. [4] From 2017 to 2020, he was the scientific director of the MFPL (since 2019 Max Perutz Labs). [4] [5] At the University Vienna, he was the dean of the Center for Molecular Biology. [6] At the Medical University of Vienna, he was the head of the Department for Medical Biochemistry. [7]
His research focuses on developing computational methods for the reconstruction of phylogenetic trees. [3] He co-authored the phylogenetics software packages TREEFINDER, [8] TREE-PUZZLE, [9] and its successor, IQ-TREE. [10] [11] However, the 2004 article about TREEFINDER in BMC Evolutionary Biology was retracted in 2015 due to the license change. [12] More precisely, coauthor Gangolf Jobb had forbidden use of the software in the USA and several European countries as an anti-immigration political statement. [13]
He sits on the editorial boards of Molecular Biology and Evolution and BMC Evolutionary Biology . [14] [15] [16]
In 2021, 2022 and 2023, Arndt von Haeseler was awarded "Highly Cited Researcher". [17] [18] [19] [20] [21]
In 2015, von Haeseler was elected as a corresponding member of the mathematics and science class of the Austrian Academy of Sciences. [14] [22]
Since 1999, he holds an honorary professorship in theoretical biology at the University of Leipzig. [14] [23]
Max Ferdinand Perutz was an Austrian-born British molecular biologist, who shared the 1962 Nobel Prize for Chemistry with John Kendrew, for their studies of the structures of haemoglobin and myoglobin. He went on to win the Royal Medal of the Royal Society in 1971 and the Copley Medal in 1979. At Cambridge he founded and chaired (1962–79) The MRC Laboratory of Molecular Biology (LMB), fourteen of whose scientists have won Nobel Prizes.
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology.
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. It differs from biological computing, a subfield of computer science and engineering which uses bioengineering to build computers.
BioMed Central (BMC) is a United Kingdom-based, for-profit scientific open access publisher that produces over 250 scientific journals. All its journals are published online only. BioMed Central describes itself as the first and largest open access science publisher. It was founded in 2000 and has been owned by Springer, now Springer Nature, since 2008.
A phylogenetic network is any graph used to visualize evolutionary relationships between nucleotide sequences, genes, chromosomes, genomes, or species. They are employed when reticulation events such as hybridization, horizontal gene transfer, recombination, or gene duplication and loss are believed to be involved. They differ from phylogenetic trees by the explicit modeling of richly linked networks, by means of the addition of hybrid nodes instead of only tree nodes. Phylogenetic trees are a subset of phylogenetic networks. Phylogenetic networks can be inferred and visualised with software such as SplitsTree, the R-package, phangorn, and, more recently, Dendroscope. A standard format for representing phylogenetic networks is a variant of Newick format which is extended to support networks as well as trees.
PHYLogeny Inference Package (PHYLIP) is a free computational phylogenetics package of programs for inferring evolutionary trees (phylogenies). It consists of 65 portable programs, i.e., the source code is written in the programming language C. As of version 3.696, it is licensed as open-source software; versions 3.695 and older were proprietary software freeware. Releases occur as source code, and as precompiled executables for many operating systems including Windows, Mac OS 8, Mac OS 9, OS X, Linux ; and FreeBSD from FreeBSD.org. Full documentation is written for all the programs in the package and is included therein. The programs in the phylip package were written by Professor Joseph Felsenstein, of the Department of Genome Sciences and the Department of Biology, University of Washington, Seattle.
Roderic Dugald Morton Page is a New Zealand-born evolutionary biologist at the University of Glasgow, Scotland, and the author of several books. As of 2015 he is professor at the University of Glasgow and was editor of the journal Systematic Biology until the end of 2007. His main interests are in phylogenetics, evolutionary biology and bioinformatics.
TREE-PUZZLE is a computer program used to construct phylogenetic trees from sequence data by maximum likelihood analysis. Branch lengths can be calculated with and without the molecular clock hypothesis.
Gustavo Caetano-Anollés is Professor of Bioinformatics in the Department of Crop Sciences, University of Illinois at Urbana-Champaign. He is an expert in the field of evolutionary and comparative genomics.
Treefinder is a computer program for the likelihood-based reconstruction of phylogenetic trees from molecular sequences. It was written by Gangolf Jobb, a former researcher at the University of Munich, Germany, and was originally released in 2004. Treefinder is free of charge, though the most recent license prohibits its use in the USA and eight European countries.
Lawrence E. Hunter is a Professor and Director of the Center for Computational Pharmacology and of the Computational Bioscience Program at the University of Colorado School of Medicine and Professor of Computer Science at the University of Colorado Boulder. He is an internationally known scholar, focused on computational biology, knowledge-driven extraction of information from the primary biomedical literature, the semantic integration of knowledge resources in molecular biology, and the use of knowledge in the analysis of high-throughput data, as well as for his foundational work in computational biology, which led to the genesis of the major professional organization in the field and two international conferences.
Tandy Warnow is an American computer scientist and Grainger Distinguished Chair in Engineering at the University of Illinois at Urbana–Champaign. She is known for her work on the reconstruction of evolutionary trees, both in biology and in historical linguistics, and also for multiple sequence alignment methods.
The Max Perutz Labs Vienna are a molecular biology research centre operated jointly by the University of Vienna and the Medical University of Vienna located at the Vienna Biocenter. The institute is named after the Viennese-born biochemist and Nobel laureate Max Ferdinand Perutz. On average, the institute hosts 50 independent research groups. Max Perutz Labs scientists participate in the undergraduate curricula for students of the University of Vienna and the Medical University of Vienna.
Bacterial phylodynamics is the study of immunology, epidemiology, and phylogenetics of bacterial pathogens to better understand the evolutionary role of these pathogens. Phylodynamic analysis includes analyzing genetic diversity, natural selection, and population dynamics of infectious disease pathogen phylogenies during pandemics and studying intra-host evolution of viruses. Phylodynamics combines the study of phylogenetic analysis, ecological, and evolutionary processes to better understand of the mechanisms that drive spatiotemporal incidence and phylogenetic patterns of bacterial pathogens. Bacterial phylodynamics uses genome-wide single-nucleotide polymorphisms (SNP) in order to better understand the evolutionary mechanism of bacterial pathogens. Many phylodynamic studies have been performed on viruses, specifically RNA viruses which have high mutation rates. The field of bacterial phylodynamics has increased substantially due to the advancement of next-generation sequencing and the amount of data available.
The Vienna BioCenter is a cluster of life science research institutes and biotechnology companies located in the 3rd municipal District of Vienna, Austria. It grew around the Research Institute of Molecular Pathology (IMP), which opened in 1988. The entities at the Vienna BioCenter employ more than 2,000 people, including 600 students.
Korbinian Strimmer is a German statistician specialising in biomedical data science. He is a professor in statistics at the University of Manchester.
Minimum evolution is a distance method employed in phylogenetics modeling. It shares with maximum parsimony the aspect of searching for the phylogeny that has the shortest total sum of branch lengths.
In phylogenetics, reconciliation is an approach to connect the history of two or more coevolving biological entities. The general idea of reconciliation is that a phylogenetic tree representing the evolution of an entity can be drawn within another phylogenetic tree representing an encompassing entity to reveal their interdependence and the evolutionary events that have marked their shared history. The development of reconciliation approaches started in the 1980s, mainly to depict the coevolution of a gene and a genome, and of a host and a symbiont, which can be mutualist, commensalist or parasitic. It has also been used for example to detect horizontal gene transfer, or understand the dynamics of genome evolution.