AsponA antisense RNA

AsponA antisense RNA
Predicted secondary structure and sequence conservation of AsponA antisense RNA
Identifiers
Rfam	RF02812
Other data
Domain	Bacteria
GO	GO:0046677
SO	SO:0000077,SO:0000370
PDB structures	PDBe

AsponA is a small asRNA transcribed antisense to the penicillin-binding protein 1A gene called ponA. It was identified by RNAseq and the expression was validated by 5' and 3' RACE experiments in Pseudomonas aeruginosa . AsponA expression was up or down regulated under different antibiotic stress. Owing to its location it may be able to prevent the transcription or translation of the opposite gene. ^[1] Study by Wurtzel et al. and Ferrara et al. also detected its expression. ^{[2] [3]}

See also

• NrsZ small RNA
• SrbA sRNA
• Pseudomonas sRNA

References

1. Gómez-Lozano M, Marvig RL, Tulstrup MV, Molin S (September 2014). "Expression of antisense small RNAs in response to stress in Pseudomonas aeruginosa". BMC Genomics. 15 (1): 783. doi: 10.1186/1471-2164-15-783 . PMC   4180829 . PMID   25213728.
2. Wurtzel O, Yoder-Himes DR, Han K, Dandekar AA, Edelheit S, Greenberg EP, Sorek R, Lory S (September 2012). "The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature". PLOS Pathogens. 8 (9) e1002945. doi: 10.1371/journal.ppat.1002945 . PMC   3460626 . PMID   23028334.
3. Ferrara S, Brugnoli M, De Bonis A, Righetti F, Delvillani F, Dehò G, Horner D, Briani F, Bertoni G (2012). "Comparative profiling of Pseudomonas aeruginosa strains reveals differential expression of novel unique and conserved small RNAs". PLOS ONE. 7 (5) e36553. Bibcode:2012PLoSO...736553F. doi: 10.1371/journal.pone.0036553 . PMC   3349714 . PMID   22590564.