SrbA sRNA

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SrbA (sRNA regulator of biofilms A) is a small regulatory non-coding RNA identified in pathogenic Pseudomonas aeruginosa [1] . It is important for biofilm formation and pathogenicity. Bacterial strain with deleted SrbA had reduced biofilm mass. As the ability to form biofilms [2] can contribute to the ability a pathogen to thrive within the host, the C. elegans hosts infected with the srbA deleted strain displayed significantly lower mortality rate than the wild-type strain. However, the deletion of srbA had no effect on growth or antibiotic resistance in P. aeruginosa. [3]

See also

References

  1. ↑ Kerr KG, Snelling AM (December 2009). "Pseudomonas aeruginosa: a formidable and ever-present adversary". The Journal of Hospital Infection. 73 (4): 338–344. doi: 10.1016/j.jhin.2009.04.020 . PMID   19699552.
  2. ↑ Stewart PS, Franklin MJ (March 2008). "Physiological heterogeneity in biofilms". Nature Reviews. Microbiology. 6 (3): 199–210. doi:10.1038/nrmicro1838. PMID   18264116. S2CID   5477887.
  3. ↑ Taylor PK, Van Kessel AT, Colavita A, Hancock RE, Mah TF (2017). "A novel small RNA is important for biofilm formation and pathogenicity in Pseudomonas aeruginosa". PLOS ONE. 12 (8) e0182582. Bibcode:2017PLoSO..1282582T. doi: 10.1371/journal.pone.0182582 . PMC   5542712 . PMID   28771593.
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