Avian influenza in cats

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Cats with avian influenza exhibit symptoms that can result in death. The avian influenza viruses cats may get include H5N1 or H7N2, [1] which are subtypes. In order to get the virus, cats need to be in contact with waterfowl, poultry, or uncooked poultry that are infected. [2] Two of the main organs that the virus affects are the lungs and liver. [3]

Contents

History

Avian influenza has been found in China, Thailand, Vietnam, Indonesia, Iraq, Austria, Germany, and Poland. Besides being found in domestic cats, the virus has infected a variety of wild cats such as the Asiatic golden cat, the clouded leopard, tigers, and leopards. [4]

H5N1 was first discovered in domestic and wild cats in Asia, [5] specifically in 2003 in the Thai zoo where two tigers and two leopards died. In 2004, the Thai zoo had 147 tigers that died or were euthanized. [6] This was then followed by an outbreak in Germany in 2006, where three stray cats were found to be either dying or dead during the peak time of the virus outbreak. [7] As of June 2023, there was an ongoing outbreak in Poland with at least 9 confirmed cases and multiple deaths. [8]

Because the virus infects the lungs of cats, it is one of the preferred model animals to study the effects of H5N1 in humans. [4]

Virus transmission

Avian influenza is a zoonotic agent. The most common way a cat can obtain H5N1 is by consuming an infected bird. This has been studied in the 2006 and 2007 cases in Germany and Austria, where the strains between the cat and the infected birds were not different between the species. [7] A cat is able to then transfer the virus via the respiratory tract and the digestive tract to other cats. However, studies suggest that a cat cannot transfer the virus to a dog, and vice versa, while sharing a food bowl. [4] Though there was no concrete evidence as of 2010, there is a potential link between the transmission of the virus between poultry, wild birds, and humans. [9]

Once the cat is infected, after an incubation period of 2 to 3 days, [5] the virus can be found in the respiratory tissues, attached to the type II pneumocytes and alveolar macrophages, [4] as well as the intestinal tissues. In some cases where the virus has been found in the brain and other systems in the body. [10]

As of 2008 the H5N1 virus had not adapted to transfer in between mammal speciess, but there was concern that this might occur. [3]

Studies in cats

One epidemiological study that was performed in Germany and Austria on 171 cats found that less than 1.8% of this population had H5N1. In this same sample population of cats, less than 2.6% had antibodies to H5N1. Even though Germany and Austria are among the countries that have had naturally occurring cases, this study shows that very few cats have contracted the disease. [11]

There have also been studies looking at the T cells, specifically CD4 and CD8, in the cat after viral infection. Though the mechanism is not fully known, there seems to be an inverse relationship with the amount of T cells present and the amount of infected cells. [12]

Another study to test whether the ALVAC recombinant canarypox virus could prime the cat immune system was performed. This vaccine has the same hemagglutinin as the H5N1 virus, and therefore worked on preventing death from two different strains of the virus, HPAIV A/Vietnam/1194/2004 and HPAIV A/Indonesia/05/2005. However, some of the cats that were vaccinated did exhibit hyperthermia and weight loss, and all of the cats did have some disease change (assuming lesions) in their lungs. All of the cats, except one, still excreted the virus even after being vaccinated. [13]

Symptoms

A cat that is infected with a high dose of the virus can show signs of fever, lethargy, and dyspnea. [10] There have even been recorded cases where a cat has neurological symptoms such as circling or ataxia. [2] In a case in February 2004, a 2-year-old male cat was panting and convulsing on top of having a fever two days prior to death. This cat also had lesions that were identified as renal congestion, pulmonary congestion, edema, and pneumonia. Upon inspection, the cat also had cerebral congestion, conjunctivitis, and hemorrhaging in the serosae of the intestines. [14]

However, a cat that is infected with a low dose of the virus may not necessarily show symptoms. Though they may be asymptomatic, they can still transfer small amounts of the virus. [4]

Treatment and prevention

Cats can be protected from H5N1 if they are given a vaccination, as mentioned above. However, it was also found that cats can still shed some of the virus but in low numbers. [4]

If a cat is exhibiting symptoms, they should be put into isolation and kept indoors. Then they should be taken to a vet to get tested for the presence of H5N1. If there is a possibility that the cat has avian influenza, then there should be extra care when handling the cat. [2] Some of the precautions include avoiding all direct contact with the cat by wearing gloves, masks, and goggles. Whatever surfaces the cat comes in contact with should be disinfected with standard household cleaners. [5]

Researchers have given tigers an antiviral treatment of oseltamivir with a dose of 75 mg/60 kg two times a day. The specific dosage was extrapolated from human data, but no data exist to suggest protection. As with many antiviral treatments, the dosage depends on the species. [5]

Related Research Articles

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<span class="mw-page-title-main">Avian influenza</span> Influenza caused by viruses adapted to birds

Avian influenza, also known as avian flu or bird flu, is a disease caused by the influenza A virus, which primarily affects birds but can sometimes affect mammals including humans. Wild aquatic birds are the primary host of the influenza A virus, which is enzootic in many bird populations.

<span class="mw-page-title-main">Feline immunodeficiency virus</span> Species of virus

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<span class="mw-page-title-main">Influenza A virus subtype H5N2</span> Virus subtype

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References

  1. ↑ Lee, Christopher T (28 July 2017). "Outbreak of Influenza A(H7N2) Among Cats in an Animal Shelter With Cat-to-Human Transmission—New York City, 2016". academic.oup.com. Retrieved 2024-05-16.
  2. 1 2 3 Thiry, Etienne; Addie, Diane; Belák, Sándor; Boucraut-Baralon, Corine; Egberink, Herman; Frymus, Tadeusz; Gruffydd-Jones, Tim; Hartmann, Katrin; Hosie, Margaret J.; Lloret, Albert (1 July 2009). "H5N1 avian influenza in cats. ABCD guidelines on prevention and management". Journal of Feline Medicine & Surgery. 11 (7): 615–618. doi:10.1016/j.jfms.2009.05.011. PMC   7128855 . PMID   19481042.
  3. 1 2 Marschall, J; Hartmann, K (1 August 2008). "Avian influenza A H5N1 infections in cats". Journal of Feline Medicine & Surgery. 10 (4): 359–365. doi:10.1016/j.jfms.2008.03.005. PMC   10832898 . PMID   18619884. S2CID   29347001.
  4. 1 2 3 4 5 6 Harder TC, Vahlenkamp TW (March 2010). "Influenza virus infections in dogs and cats". Vet. Immunol. Immunopathol. 134 (1–2): 54–60. doi:10.1016/j.vetimm.2009.10.009. PMID   19896216.
  5. 1 2 3 4 Philippa J, Baas C, Beyer W, et al. (May 2007). "Vaccination against highly pathogenic avian influenza H5N1 virus in zoos using an adjuvanted inactivated H5N2 vaccine". Vaccine. 25 (19): 3800–8. doi:10.1016/j.vaccine.2007.01.121. PMID   17403559.
  6. ↑ Yee KS, Carpenter TE, Cardona CJ (July 2009). "Epidemiology of H5N1 avian influenza". Comp. Immunol. Microbiol. Infect. Dis. 32 (4): 325–40. doi:10.1016/j.cimid.2008.01.005. PMID   18448168.
  7. 1 2 Starick, E.; Beer, M.; Hoffmann, B.; Staubach, C.; Werner, O.; Globig, A.; Strebelow, G.; Grund, C.; Durban, M.; Conraths, F.J.; Mettenleiter, T.; Harder, T. (1 April 2008). "Phylogenetic analyses of highly pathogenic avian influenza virus isolates from Germany in 2006 and 2007 suggest at least three separate introductions of H5N1 virus" (PDF). Veterinary Microbiology. 128 (3–4): 243–252. doi:10.1016/j.vetmic.2007.10.012. PMID   18031958.
  8. ↑ Schnirring, Lisa. "Polish officials probe H5N1 avian flu link to cat deaths". Center for Infectious Disease Research and Policy. University of Minnesota. Retrieved 28 June 2023.
  9. ↑ Kalthoff D, Globig A, Beer M (January 2010). "(Highly pathogenic) avian influenza as a zoonotic agent". Vet. Microbiol. 140 (3–4): 237–45. doi:10.1016/j.vetmic.2009.08.022. PMID   19782482.
  10. 1 2 Belser JA, Tumpey TM (February 2013). "H5N1 pathogenesis studies in mammalian models". Virus Res. 178 (1): 168–85. doi:10.1016/j.virusres.2013.02.003. PMC   5858902 . PMID   23458998.
  11. ↑ Marschall, J; Schulz, B; Harderprivdoz, T; Vahlenkampprivdoz, T; Huebner, J; Huisinga, E; Hartmann, K (1 August 2008). "Prevalence of influenza A H5N1 virus in cats from areas with occurrence of highly pathogenic avian influenza in birds". Journal of Feline Medicine & Surgery. 10 (4): 355–358. doi: 10.1016/j.jfms.2008.03.007 . PMC   10832910 . PMID   18640861. S2CID   6326717.
  12. ↑ Giese, Matthias; Harder, Timm C.; Teifke, Jens P.; Mettenleiter, Thomas C.; Vahlenkamp, Thomas W. (1 March 2009). "The role of T cells in avian influenza H5N1 infected cats". Veterinary Immunology and Immunopathology. 128 (1–3): 343. doi:10.1016/j.vetimm.2008.10.282.
  13. ↑ Stittelaar, Koert J.; Lacombe, Valérie; van Lavieren, Rob; van Amerongen, Geert; Simon, James; Cozette, Valérie; Swayne, David E.; Poulet, Hervé; Osterhaus, Albert D.M.E. (1 July 2010). "Cross-clade immunity in cats vaccinated with a canarypox-vectored avian influenza vaccine". Vaccine. 28 (31): 4970–4976. doi:10.1016/j.vaccine.2010.05.028. PMID   20566392.
  14. ↑ Cardona CJ, Xing Z, Sandrock CE, Davis CE (July 2009). "Avian influenza in birds and mammals". Comp. Immunol. Microbiol. Infect. Dis. 32 (4): 255–73. doi:10.1016/j.cimid.2008.01.001. PMID   18485480.
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