B4GALNT2

B4GALNT2
Identifiers
Aliases	B4GALNT2 , B4GALT, GALGT2, beta-1,4-N-acetyl-galactosaminyltransferase 2
External IDs	OMIM: 111730 MGI: 1342058 HomoloGene: 7329 GeneCards: B4GALNT2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,176,840 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,805,717 bp
RNA expression pattern
	Top expressed in
	rectum; ; appendix; ; body of stomach; ; kidney; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; gallbladder; ; fundus; ; smooth muscle tissue; ; pharynx;
	Top expressed in
	duodenum; ; crypt of lieberkuhn of small intestine; ; yolk sac; ; parotid gland; ; jejunum; ; intestinal villus; ; ileum; ; Paneth cell; ; left colon; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; hexosyltransferase activity ; glycosyltransferase activity ; acetylgalactosaminyltransferase activity ;
Cellular component	integral component of membrane ; integral component of Golgi membrane ; Golgi apparatus ; membrane ; Golgi membrane ;
Biological process	UDP-N-acetylglucosamine metabolic process ; protein glycosylation ; UDP-N-acetylgalactosamine metabolic process ; lipid glycosylation ; negative regulation of cell-cell adhesion ; protein N-linked glycosylation via asparagine ;
	Sources:Amigo / QuickGO
Orthologs
	124872
	14422
	ENSG00000167080
	ENSMUSG00000013418
	Q8NHY0
	Q09199
	NM_001159387 ; NM_001159388 ; NM_153446
	NM_008081
	NP_001152859 ; NP_001152860 ; NP_703147
	NP_032107
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Beta-1,4 N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the B4GALNT2 gene.^[5]^[6]^[7]

Related Research Articles

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Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene.

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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. This enzyme adds a N-Acetylneuraminic acid to an O-linked N-Acetylgalactosamine (GalNAc) on a peptide/proteins with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers Thr over Ser containing GalNAc residues.

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The Sid blood group system is a human blood group defined by the presence or absence of the Sd(a) antigen on a person's red blood cells. About 96% of people are positive for the Sd(a) antigen, which is inherited as a dominant trait. Among Sd(a) positive individuals, the expression of the antigen ranges from extremely weak to extremely strong. Very strong expression of the antigen is referred to as a Sd(a++) phenotype. In addition to being expressed on red blood cells, Sd(a) is secreted in bodily fluids such as saliva and breast milk, and is found in the highest concentrations in urine. Urine testing is considered the most reliable method for determining a person's Sid blood type.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167080 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013418 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dohi T, Yuyama Y, Natori Y, Smith PL, Lowe JB, Oshima M (Sep 1996). "Detection of N-acetylgalactosaminyltransferase mRNA which determines expression of Sda blood group carbohydrate structure in human gastrointestinal mucosa and cancer". International Journal of Cancer. 67 (5): 626–31. doi: 10.1002/(SICI)1097-0215(19960904)67:5<626::AID-IJC6>3.0.CO;2-W . PMID 8782649.
↑ Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A (Jul 2003). "Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain". The Biochemical Journal. 373 (Pt 2): 369–79. doi:10.1042/BJ20021892. PMC 1223490 . PMID 12678917.
↑ "Entrez Gene: B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2".

External links

Human B4GALNT2 genome location and B4GALNT2 gene details page in the UCSC Genome Browser .

Berger EG (Feb 2002). "Ectopic localizations of Golgi glycosyltransferases". Glycobiology. 12 (2): 29R–36R. doi: 10.1093/glycob/12.2.29R . PMID 11886838.
Wang HR, Hsieh CY, Twu YC, Yu LC (Jan 2008). "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status". Glycobiology. 18 (1): 104–13. doi: 10.1093/glycob/cwm120 . PMID 17965433.
Kawamura YI, Kawashima R, Fukunaga R, Hirai K, Toyama-Sorimachi N, Tokuhara M, Shimizu T, Dohi T (Jul 2005). "Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis". Cancer Research. 65 (14): 6220–7. doi: 10.1158/0008-5472.CAN-05-0639 . PMID 16024623.
Lo Presti L, Cabuy E, Chiricolo M, Dall'Olio F (Nov 2003). "Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain". Journal of Biochemistry. 134 (5): 675–82. doi:10.1093/jb/mvg192. PMID 14688233.
Piller F, Blanchard D, Huet M, Cartron JP (Jun 1986). "Identification of a alpha-NeuAc-(2----3)-beta-D-galactopyranosyl N-acetyl-beta-D-galactosaminyltransferase in human kidney". Carbohydrate Research. 149 (1): 171–84. doi:10.1016/S0008-6215(00)90376-8. PMID 2425965.
Li PT, Liao CJ, Wu WG, Yu LC, Chu ST (Jun 2011). "Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice" (PDF). Fertility and Sterility. 95 (7): 2404–9, 2409.e1–3. doi:10.1016/j.fertnstert.2011.03.043. PMID 21481371.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167080 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013418 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8782649-5] Dohi T, Yuyama Y, Natori Y, Smith PL, Lowe JB, Oshima M (Sep 1996). "Detection of N-acetylgalactosaminyltransferase mRNA which determines expression of Sda blood group carbohydrate structure in human gastrointestinal mucosa and cancer". International Journal of Cancer. 67 (5): 626–31. doi: 10.1002/(SICI)1097-0215(19960904)67:5<626::AID-IJC6>3.0.CO;2-W . PMID 8782649.

[pmid12678917-6] Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A (Jul 2003). "Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain". The Biochemical Journal. 373 (Pt 2): 369–79. doi:10.1042/BJ20021892. PMC 1223490 . PMID 12678917.

[entrez-7] "Entrez Gene: B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2".

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B4GALNT2

Contents

Related Research Articles

References

External links

Further reading