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In physics, coherence expresses the potential for two waves to interfere. Two monochromatic beams from a single source always interfere. Physical sources are not strictly monochromatic: they may be partly coherent. Beams from different sources are mutually incoherent.
Optical coherence tomography (OCT) is an imaging technique that uses interferometry with short-coherence-length light to obtain micrometer-level depth resolution and uses transverse scanning of the light beam to form two- and three-dimensional images from light reflected from within biological tissue or other scattering media. Short-coherence-length light can be obtained using a superluminescent diode (SLD) with a broad spectral bandwidth or a broadly tunable laser with narrow linewidth. The first demonstration of OCT imaging was published by a team from MIT and Harvard Medical School in a 1991 article in the journal Science. The article introduced the term "OCT" to credit its derivation from optical coherence-domain reflectometry, in which the axial resolution is based on temporal coherence. The first demonstrations of in vivo OCT imaging quickly followed.
Quantum optics is a branch of atomic, molecular, and optical physics dealing with how individual quanta of light, known as photons, interact with atoms and molecules. It includes the study of the particle-like properties of photons. Photons have been used to test many of the counter-intuitive predictions of quantum mechanics, such as entanglement and teleportation, and are a useful resource for quantum information processing.
Medical optical imaging is the use of light as an investigational imaging technique for medical applications, pioneered by American Physical Chemist Britton Chance. Examples include optical microscopy, spectroscopy, endoscopy, scanning laser ophthalmoscopy, laser Doppler imaging, and optical coherence tomography. Because light is an electromagnetic wave, similar phenomena occur in X-rays, microwaves, and radio waves.
David L. Fried was an American scientist, best known for his contributions to optics. Fried described what has come to be known as the Fried Parameter, or r0. The Fried Parameter is a measure of the strength of the turbulence in the atmosphere of Earth. The turbulence causes what is known as seeing in astronomy and usually limits the optical resolution of ground-based telescopes and the detail in their images of astronomical objects. The Fried Parameter describes the smallest diameter of a telescope aperture at which the image fidelity starts to suffer significantly from turbulent airflows in the atmosphere of Earth. The Fried Parameter may change quickly on the time scale of minutes, or less. Typical values for the Fried Parameter in the visible spectrum may range from less than one centimeter to some tens of centimeters at good astronomical sites.
Resonance-enhanced multiphoton ionization (REMPI) is a technique applied to the spectroscopy of atoms and small molecules. In practice, a tunable laser can be used to access an excited intermediate state. The selection rules associated with a two-photon or other multiphoton photoabsorption are different from the selection rules for a single photon transition. The REMPI technique typically involves a resonant single or multiple photon absorption to an electronically excited intermediate state followed by another photon which ionizes the atom or molecule. The light intensity to achieve a typical multiphoton transition is generally significantly larger than the light intensity to achieve a single photon photoabsorption. Because of this, subsequent photoabsorption is often very likely. An ion and a free electron will result if the photons have imparted enough energy to exceed the ionization threshold energy of the system. In many cases, REMPI provides spectroscopic information that can be unavailable to single photon spectroscopic methods, for example rotational structure in molecules is easily seen with this technique.
Modeling photon propagation with Monte Carlo methods is a flexible yet rigorous approach to simulate photon transport. In the method, local rules of photon transport are expressed as probability distributions which describe the step size of photon movement between sites of photon-matter interaction and the angles of deflection in a photon's trajectory when a scattering event occurs. This is equivalent to modeling photon transport analytically by the radiative transfer equation (RTE), which describes the motion of photons using a differential equation. However, closed-form solutions of the RTE are often not possible; for some geometries, the diffusion approximation can be used to simplify the RTE, although this, in turn, introduces many inaccuracies, especially near sources and boundaries. In contrast, Monte Carlo simulations can be made arbitrarily accurate by increasing the number of photons traced. For example, see the movie, where a Monte Carlo simulation of a pencil beam incident on a semi-infinite medium models both the initial ballistic photon flow and the later diffuse propagation.
The European X-Ray Free-Electron Laser Facility is an X-ray research laser facility commissioned during 2017. The first laser pulses were produced in May 2017 and the facility started user operation in September 2017. The international project with twelve participating countries; nine shareholders at the time of commissioning, later joined by three other partners, is located in the German federal states of Hamburg and Schleswig-Holstein. A free-electron laser generates high-intensity electromagnetic radiation by accelerating electrons to relativistic speeds and directing them through special magnetic structures. The European XFEL is constructed such that the electrons produce X-ray light in synchronisation, resulting in high-intensity X-ray pulses with the properties of laser light and at intensities much brighter than those produced by conventional synchrotron light sources.
Quantum imaging is a new sub-field of quantum optics that exploits quantum correlations such as quantum entanglement of the electromagnetic field in order to image objects with a resolution or other imaging criteria that is beyond what is possible in classical optics. Examples of quantum imaging are quantum ghost imaging, quantum lithography, imaging with undetected photons, sub-shot-noise imaging, and quantum sensing. Quantum imaging may someday be useful for storing patterns of data in quantum computers and transmitting large amounts of highly secure encrypted information. Quantum mechanics has shown that light has inherent “uncertainties” in its features, manifested as moment-to-moment fluctuations in its properties. Controlling these fluctuations—which represent a sort of “noise”—can improve detection of faint objects, produce better amplified images, and allow workers to more accurately position laser beams.
Optical heterodyne detection is a method of extracting information encoded as modulation of the phase, frequency or both of electromagnetic radiation in the wavelength band of visible or infrared light. The light signal is compared with standard or reference light from a "local oscillator" (LO) that would have a fixed offset in frequency and phase from the signal if the latter carried null information. "Heterodyne" signifies more than one frequency, in contrast to the single frequency employed in homodyne detection.
The photoacoustic Doppler effect is a type of Doppler effect that occurs when an intensity modulated light wave induces a photoacoustic wave on moving particles with a specific frequency. The observed frequency shift is a good indicator of the velocity of the illuminated moving particles. A potential biomedical application is measuring blood flow.
Speckle, speckle pattern, or speckle noise designates the granular structure observed in coherent light, resulting from random interference. Speckle patterns are used in a wide range of metrology techniques, as they generally allow high sensitivity and simple setups. They can also be a limiting factor in imaging systems, such as radar, synthetic aperture radar (SAR), medical ultrasound and optical coherence tomography. Speckle is not external noise; rather, it is an inherent fluctuation in diffuse reflections, because the scatterers are not identical for each cell, and the coherent illumination wave is highly sensitive to small variations in phase changes.
Ultrasound-modulated optical tomography (UOT), also known as Acousto-Optic Tomography (AOT), is a hybrid imaging modality that combines light and sound; it is a form of tomography involving ultrasound. It is used in imaging of biological soft tissues and has potential applications for early cancer detection. As a hybrid modality which uses both light and sound, UOT provides some of the best features of both: the use of light provides strong contrast and sensitivity ; these two features are derived from the optical component of UOT. The use of ultrasound allows for high resolution, as well as a high imaging depth. However, the difficulty of tackling the two fundamental problems with UOT have caused UOT to evolve relatively slowly; most work in the field is limited to theoretical simulations or phantom / sample studies.
Robert Alfano is an Italian-American experimental physicist. He is a Distinguished Professor of Science and Engineering at the City College and the Graduate School of the City University of New York, where he is also the founding director of the Institute for Ultrafast Spectroscopy and Lasers (1982). He is a pioneer in the fields of Biomedical Imaging and Spectroscopy, Ultrafast lasers and optics, tunable lasers, semiconductor materials and devices, optical materials, biophysics, nonlinear optics and photonics; he has also worked extensively in nanotechnology and coherent backscattering. His discovery of the white-light supercontinuum laser is at the root of optical coherence tomography, which is breaking barriers in ophthalmology, cardiology, and oral cancer detection among other applications. He initiated the field known now as Optical Biopsy
A random laser (RL) is a laser in which optical feedback is provided by scattering particles. As in conventional lasers, a gain medium is required for optical amplification. However, in contrast to Fabry–Pérot cavities and distributed feedback lasers, neither reflective surfaces nor distributed periodic structures are used in RLs, as light is confined in an active region by diffusive elements that either may or may not be spatially distributed inside the gain medium.
Light-in-flight imaging — a set of techniques to visualize propagation of light through different media.
The collimated transmission method is a direct way of measuring the optical properties of materials. It is especially useful for sensing the optical properties of tissues to guide developments of both diagnostic and therapeutic techniques. These optical properties are described by the absorption coefficient μa, scattering coefficient μs, and anisotropy factor g.
Multiple scattering low coherence interferometry (ms/LCI) is an imaging technique that relies on analyzing multiply scattered light in order to capture depth-resolved images from optical scattering media. With current applications primarily in medical imaging, has the advantage of a higher range since forward scattered light attenuates less with depth when compared to the specularly reflected light that is assessed in more conventional imaging methods such as optical coherence tomography. This allows ms/LCI to image through up to 90 mean free scattering paths, compared to roughly 27 scattering MFPs in OCT and 1–2 scattering MFPs in confocal microscopy.
Coherent Raman scattering (CRS) microscopy is a multi-photon microscopy technique based on Raman-active vibrational modes of molecules. The two major techniques in CRS microscopy are stimulated Raman scattering (SRS) and coherent anti-Stokes Raman scattering (CARS). SRS and CARS were theoretically predicted and experimentally realized in the 1960s. In 1982 the first CARS microscope was demonstrated. In 1999, CARS microscopy using a collinear geometry and high numerical aperture objective were developed in Xiaoliang Sunney Xie's lab at Harvard University. This advancement made the technique more compatible with modern laser scanning microscopes. Since then, CRS's popularity in biomedical research started to grow. CRS is mainly used to image lipid, protein, and other bio-molecules in live or fixed cells or tissues without labeling or staining. CRS can also be used to image samples labeled with Raman tags, which can avoid interference from other molecules and normally allows for stronger CRS signals than would normally be obtained for common biomolecules. CRS also finds application in other fields, such as material science and environmental science.
Dual-axis optical coherence tomography (DA-OCT) is an imaging modality that is based on the principles of optical coherence tomography (OCT). These techniques are largely used for medical imaging. OCT is non-invasive and non-contact. It allows for real-time, in situ imaging and provides high image resolution. OCT is analogous to ultrasound but relies on light waves, which makes it faster than ultrasound. In general, OCT has proven to be compact and portable. It is compatible with arterial catheters and endoscopes, which helps diagnose diseases within long internal cavities, including the esophagus and coronary arteries.
References
- ↑ Lihong V. Wang; Hsin-i Wu (26 September 2012). Biomedical Optics: Principles and Imaging. John Wiley & Sons. pp. 3–. ISBN 978-0-470-17700-6.
- K. Yoo and R. R. Alfano, "Time-resolved coherent and incoherent components of forward light scattering in random media", Optics Letters 15, 320–322 (1990).
- L Wang, P P Ho, C Liu, G Zhang, R R Alfano "Ballistic 2-d imaging through scattering walls using an ultrafast optical kerr gate" 1991, August 16th
- K. M. Yoo and R. R. Alfano "Time-resolved coherent and incoherent components of forward light scattering in random media" 1990
- K. M. Yoo, Feng Liu, and R. R. Alfano "When does the diffusion approximation fail to describe photon transport in random media?" 28 May 1990
- S. Farsiu, J. Christofferson, B. Eriksson, P. Milanfar, B. Friedlander, A. Shakouri, R. Nowak, "Statistical detection and imaging of objects hidden in turbid media using ballistic photons", Applied Optics, vol. 46, no. 23, pp. 5805–5822, Aug. 2007.