Barbara J. Bain | |
---|---|
Born | Barbara Jane Reid July 27, 1941 |
Nationality | Australian |
Known for | Contributions to field of haematology |
Title | Professor |
Academic background | |
Alma mater | University of Queensland |
Academic work | |
Discipline | Medicine |
Sub-discipline | Haematology,Oncology |
Institutions | Imperial College Faculty of Medicine St Mary's Hospital,London |
Barbara Jane Bain (born 1941) is an Australian haematologist and oncologist. She is a professor at the Imperial College Faculty of Medicine and a consultant at St Mary's Hospital,London. She is known as the author of reference textbooks in the field of haematology that form the core curriculum for laboratory morphology and pathology. [1] [2]
Bain grew up in Australia and was educated in Maryborough,Queensland. [3] She completed her undergraduate studies at the University of Queensland,where she was awarded the University Gold Medal.[ citation needed ] She was a registrar at the Princess Alexandra Hospital. She traveled to England in late 1971,supported by a scholarship from the Royal Australasian College of Physicians. [4] [5] She said that she wanted to work in haematology due to a combination of laboratory and clinical work. [6]
In 1972,Bain joined St Mary's Hospital as a lecturer,where she was made a reader in 2000 and professor in 2004.[ citation needed ] She is an expert in haematology and the translation of laboratory breakthroughs to clinical science. [7] [8] For example,she investigated myelodysplastic syndrome,which can evolve into acute myeloid leukaemia and dysplastic haemopoiesis without proper diagnosis and treatment. [9]
At St Mary's,Bain developed a training program on haematology,covering topics such as the analysis of blood and bone marrow samples and genetic disorders that affect haemoglobin. She helped to develop bloodmed.com,an online educational course that is taken by almost all UK trainees. The course was incorporated to the British Society for Haematology website. [10] She was part of the International Working Group on Morphology of MDS and also in the group which devised the 2008 WHO classification of tumours of the lymphoid haematopoietic systems. [11] She has translated two editions of an Italian work on the morphology of the blood. [12] In 2019,the Queensland University of Technology announced the Barbara Bain prize for Haematology. [13]
A myelodysplastic syndrome (MDS) is one of a group of cancers in which immature blood cells in the bone marrow do not mature, and as a result, do not develop into healthy blood cells. Early on, no symptoms typically are seen. Later, symptoms may include fatigue, shortness of breath, bleeding disorders, anemia, or frequent infections. Some types may develop into acute myeloid leukemia.
Neutropenia is an abnormally low concentration of neutrophils in the blood. Neutrophils make up the majority of circulating white blood cells and serve as the primary defense against infections by destroying bacteria, bacterial fragments and immunoglobulin-bound viruses in the blood. People with neutropenia are more susceptible to bacterial infections and, without prompt medical attention, the condition may become life-threatening.
Pancytopenia is a medical condition in which there is significant reduction in the number of almost all blood cells.
Macrocytosis is a condition where red blood cells are larger than normal. These enlarged cells, also known as macrocytes, are defined by a mean corpuscular volume (MCV) that exceeds the upper reference range established by the laboratory and hematology analyzer. Upon examination of a peripheral blood smear under microscope, these macrocytes appear larger than standard erythrocytes. It’s noteworthy that macrocytosis is a common morphological feature in neonatal peripheral blood. The presence of macrocytosis can indicate a range of conditions, from benign, treatable illnesses to more serious underlying disorders.
Sideroblastic anemia, or sideroachrestic anemia, is a form of anemia in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). In sideroblastic anemia, the body has iron available but cannot incorporate it into hemoglobin, which red blood cells need in order to transport oxygen efficiently. The disorder may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome, which can develop into hematological malignancies.
Acute erythrocyte leukemia is a rare form of acute myeloid leukemia where the myeloproliferation is of erythrocytic precursors. It is defined as type "M6" under the FAB classification.
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. Symptoms may include feeling tired, shortness of breath, easy bruising and bleeding, and increased risk of infection. Occasionally, spread may occur to the brain, skin, or gums. As an acute leukemia, AML progresses rapidly, and is typically fatal within weeks or months if left untreated.
Chronic myelomonocytic leukemia (CMML) is a type of leukemia, which are cancers of the blood-forming cells of the bone marrow. In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis. In CMML, there are increased numbers of monocytes and immature blood cells (blasts) in the peripheral blood and bone marrow, as well as abnormal looking cells (dysplasia) in at least one type of blood cell.
Toxic granulation refers to dark coarse granules found in granulocytes, particularly neutrophils, in patients with inflammatory conditions.
Juvenile myelomonocytic leukemia (JMML) is a rare form of chronic leukemia that affects children, commonly those aged four and younger. The name JMML now encompasses all diagnoses formerly referred to as juvenile chronic myeloid leukemia (JCML), chronic myelomonocytic leukemia of infancy, and infantile monosomy 7 syndrome. The average age of patients at diagnosis is two (2) years old. The World Health Organization has included JMML as a subcategory of myelodysplastic and myeloproliferative disorders.
Neutrophil hypersegmentation can be defined as the presence of neutrophils whose nuclei have six or more lobes or the presence of more than 3% of neutrophils with at least five nuclear lobes. This is a clinical laboratory finding. It is visualized by drawing blood from a patient and viewing the blood smeared on a slide under a microscope. Normal neutrophils are uniform in size, with an apparent diameter of about 13 μm in a film. When stained, neutrophils have a segmented nucleus and pink/orange cytoplasm under light microscope. The majority of neutrophils have three nuclear segments (lobes) connected by tapering chromatin strands. A small percentage have four lobes, and occasionally five lobes may be seen. Up to 8% of circulating neutrophils are unsegmented.
Congenital hypoplastic anemia is a congenital disorder that occasionally also includes leukopenia and thrombocytopenia and is characterized by deficiencies of red cell precursors.
In hematology, red cell agglutination or autoagglutination is a phenomenon in which red blood cells clump together, forming aggregates. It is caused by the surface of the red cells being coated with antibodies. This often occurs in cold agglutinin disease, a type of autoimmune hemolytic anemia in which people produce antibodies that bind to their red blood cells at cold temperatures and destroy them. People may develop cold agglutinins from lymphoproliferative disorders, from infection with Mycoplasma pneumoniae or Epstein–Barr virus, or idiopathically. Red cell agglutination can also occur in paroxysmal nocturnal hemoglobinuria and warm autoimmune hemolytic anemia. In cases of red cell agglutination, the direct antiglobulin test can be used to demonstrate the presence of antibodies bound to the red cells.
Bone marrow failure occurs in individuals who produce an insufficient amount of red blood cells, white blood cells or platelets. Red blood cells transport oxygen to be distributed throughout the body's tissue. White blood cells fight off infections that enter the body. Bone marrow also contains platelets, which trigger clotting, and thus help stop the blood flow when a wound occurs.
Refractory cytopenia of childhood is a subgroup of myelodysplastic syndrome (MDS), having been added to the World Health Organization classification in 2008. Before then, RCC cases were classified as childhood aplastic anemia. RCC is the most common form of MDS in children and adolescents, accounting for approximately half of all MDS cases.
Allan Victor Hoffbrand is emeritus Professor of Haematology at University College, London. He is distinguished for his research and as an author of internationally read textbooks of haematology. He was born in Bradford, Yorkshire in 1935. After education at Bradford Grammar School, he gained an Open Scholarship in 1953 to The Queen's College, Oxford. He gained a BA degree in Physiology and began clinical studies at The London Hospital in 1957 and qualified in medicine at University of Oxford, BM BCH in 1959.
Azra Raza is the Chan Soon-Shiong Professor of Medicine and Director of the Myelodysplastic Syndrome (MDS) Center at Columbia University. She has previously held positions at Roswell Park Comprehensive Cancer Center, University of Cincinnati, Rush University, and the University of Massachusetts. Raza's research focuses on myelodysplastic syndrome and acute myeloid leukemia.
Toxic vacuolation, also known as toxic vacuolization, is the formation of vacuoles in the cytoplasm of neutrophils in response to severe infections or inflammatory conditions.
A white blood cell differential is a medical laboratory test that provides information about the types and amounts of white blood cells in a person's blood. The test, which is usually ordered as part of a complete blood count (CBC), measures the amounts of the five normal white blood cell types – neutrophils, lymphocytes, monocytes, eosinophils and basophils – as well as abnormal cell types if they are present. These results are reported as percentages and absolute values, and compared against reference ranges to determine whether the values are normal, low, or high. Changes in the amounts of white blood cells can aid in the diagnosis of many health conditions, including viral, bacterial, and parasitic infections and blood disorders such as leukemia.
Transfusion-dependent anemia is a form of anemia characterized by the need for continuous blood transfusion. It is a condition that results from various diseases, and is associated with decreased survival rates. Regular transfusion is required to reduce the symptoms of anemia by increasing functional red blood cells and hemoglobin count. Symptoms may vary based on the severity of the condition and the most common symptom is fatigue. Various diseases can lead to transfusion-dependent anemia, most notably myelodysplastic syndromes (MDS) and thalassemia. Due to the number of diseases that can cause transfusion-dependent anemia, diagnosing it is more complicated. Transfusion dependence occurs when an average of more than 2 units of blood transfused every 28 days is required over a period of at least 3 months. Myelodysplastic syndromes is often only diagnosed when patients become anemic, and transfusion-dependent thalassemia is diagnosed based on gene mutations. Screening for heterozygosity in the thalassemia gene is an option for early detection.