Barry Pittendrigh | |
---|---|
Born | Regina, Saskatchewan |
Nationality | Canadian-American |
Title | John V. Osmun Endowed Chair |
Academic background | |
Education | B.Sc. Honours, Biology (1990) M.S., Entomology (1994) Ph.D., Entomology (1999) |
Alma mater | University of Regina Purdue University University of Wisconsin at Madison |
Academic work | |
Institutions | Purdue University |
Barry Robert Pittendrigh is a Canadian American molecular biologist,researcher and educator. He holds the John V. Osmun Endowed Chair and is the Director of the Center for Urban and Industrial Pest Management at Purdue University. [1]
Pittendrigh's research has been focused on the molecular mechanisms of insecticide resistance,the structural and functional genomics of head and body lice,the genomics of termites,and the development of pest controls strategies for cowpea pests within a West African context. He has written over 175 scientific papers and book chapters. [2]
Pittendrigh is the co-founder of Scientific Animations Without Borders (SAWBO),which is a research program and extension approach for conveying scientific and extension information through two-and three-dimensional animations. [3]
Pittendrigh was born and raised in Regina,Saskatchewan,where he went to Thom Collegiate. He received his B.Sc. Honours in Biology from University of Regina in 1990 and was awarded the University Prize in Science upon graduation. During his undergraduate career he worked as a summer student at the Plant Biotechnology Institute at National Research Council in Saskatoon,Canada. [4] Later he moved to the United States,where he received his M.S. in Entomology from Purdue University in 1994 and a Ph.D. in Entomology from University of Wisconsin-Madison in 1999. During his PhD program he spent time,as a visiting student,at both the University of Chicago in the Department of Ecology and Evolution and at CSIRO at Black Mountain in Canberra,Australia. He completed his post-doctoral training at the Max Planck Institute for Chemical Ecology in Jena,Germany,in 2000. [5]
In 2000,Pittendrigh joined Purdue University as an assistant professor in the Department Entomology,becoming associate professor in 2004. [6] In 2008,he left Purdue University and joined University of Illinois at Urbana-Champaign,where he was both a professor and held the C.W. Kearns,C.L. Metcalf and W.P. Flint Endowed Chair in Insect Toxicology. [7]
Pittendrigh left the University of Illinois at Urbana-Champaign in 2016 to join Michigan State University,where he holds an MSU Foundation Professor position. In 2018,Michigan State University appointed him as the associate departmental chairperson of the Department of Entomology and the director of Feed the Future Legume Systems Research Innovations Lab. [8] [9]
In January of 2021,he returned to Purdue University where he holds John V. Osmun Endowed Chair and is the Director of the Center for Urban and Industrial Pest Management. [10]
In 2011,Pittendrigh was invited to speak at TEDxUIUC,where he spoke about a program he co-founded,Scientific Animations Without Borders. [11] In 2017,he was invited to be a representative to the International Year of Pulses event at the United Nations. [12]
He has served on the editorial boards of Pesticide Biochemistry and Physiology and the International Journal of Tropical Insect Sciences. [13]
Pittendrigh has used Drosophila melanogaster as a model system to understand how organisms respond to dietary factors [14] or drugs, [15] or evolve resistance to xenobiotics such as pesticides. Most notably his research has used genomic,transcriptomic,and proteomic approaches to understand the evolution of resistance to pesticides. His later work in this area has been focused on the role of microRNAs in the evolution of pesticide resistance. [16]
Pittendrigh was the lead author on the White Paper that was funded by NIH for the sequencing of the body louse genome. [17] Subsequently,he served as the director and community coordinator of the Body Louse Genome Sequencing Consortium,a group of over 60 scientists that worked to develop an understanding of the annotation and interpretation of the body louse genome sequence and the genome of the obligate endosymbiont that lives in the body louse. The project was active from 2005 to 2010. The resultant paper was published in PNAS. Pittendrigh has actively published on work facilitated by the availability of this genome,including research on determining that parasites evolve faster than their hosts,understanding vector competence in body lice (as compared to head lice that do not vector diseases), [18] and demonstrating that body lice develop from head lice during low hygiene conditions. [19]
A large part of Pittendrigh's work has also been focused on international development,specifically in West Africa. He,his laboratory team,and his collaborators,spread across five countries in West Africa,including Nigeria,Niger,Burkina Faso,Mali,and Ghana,developed environmentally benign pest control solutions to minimize the populations of pest insects that attack cowpea,an important protein source for the local populace. [20] [21] [22]
In 2011,Pittendrigh and collaborator Dr. Julia Bello-Bravo,launched Scientific Animations Without Borders (SAWBO),a program focused on taking scientifically validated expert knowledge and placing it into a format understandable by people of all literacy levels,where the content can be placed into numerous languages. The resultant educational content is made freely available for other international development organizations to integrate into their educational programs as they see fit. SAWBO has been featured on PBS, [23] The Big Ten Network and in Reuters [24] as well as in other local US-based news outlets. SAWBO also represents a research platform to study the last mile problem of how to deliver educational content to people in remote areas in developing nation countries. SAWBO has worked with major development organizations such as the United States Agency for International Development and the World Health Organization regarding scientific messaging. [25] [26] [27] A study conducted by Pittendrigh and his colleagues in rural Mozambique revealed that intervention by animation could result in upwards of an 89% adoption rate of the technique being demonstrated in the animation in the local language. Based on long-term large datasets of global content use,they were able to demonstrate,that 2016 marked the tipping point of when cell phones overtook computers as the primary mechanism by which people accessed educational videos as learning tools. [28] [29]
In 2020,SAWBO was awarded a grant by Feed the Future Initiative to launch the Feed the Future SAWBO Responsive-Adaptive-Participatory Information Dissemination Scaling Program which will disseminate information related to COVID-19's economic impact to the general public. [30] [31]
Drosophila is a genus of flies,belonging to the family Drosophilidae,whose members are often called "small fruit flies" or pomace flies,vinegar flies,or wine flies,a reference to the characteristic of many species to linger around overripe or rotting fruit. They should not be confused with the Tephritidae,a related family,which are also called fruit flies;tephritids feed primarily on unripe or ripe fruit,with many species being regarded as destructive agricultural pests,especially the Mediterranean fruit fly.
Louse is the common name for any member of the clade Phthiraptera,which contains nearly 5,000 species of wingless parasitic insects. Phthiraptera has variously been recognized as an order,infraorder,or a parvorder,as a result of developments in phylogenetic research.
Drosophila melanogaster is a species of fly in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly,or less commonly the "vinegar fly" or "pomace fly". Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism,D. melanogaster continues to be widely used for biological research in genetics,physiology,microbial pathogenesis,and life history evolution. As of 2017,five Nobel Prizes have been awarded to drosophilists for their work using the insect.
The head louse is an obligate ectoparasite of humans. Head lice are wingless insects that spend their entire lives on the human scalp and feed exclusively on human blood. Humans are the only known hosts of this specific parasite,while chimpanzees and bonobos host a closely related species,Pediculus schaeffi. Other species of lice infest most orders of mammals and all orders of birds.
Psyllidae,the jumping plant lice or psyllids,are a family of small plant-feeding insects that tend to be very host-specific,i.e. each plant-louse species only feeds on one plant species (monophagous) or feeds on a few closely related plants (oligophagous). Together with aphids,phylloxerans,scale insects and whiteflies,they form the group called Sternorrhyncha,which is considered to be the most "primitive" group within the true bugs (Hemiptera). They have traditionally been considered a single family,Psyllidae,but recent classifications divide the group into a total of seven families;the present restricted definition still includes more than 70 genera in the Psyllidae. Psyllid fossils have been found from the Early Permian before the flowering plants evolved. The explosive diversification of the flowering plants in the Cretaceous was paralleled by a massive diversification of associated insects,and many of the morphological and metabolic characters that the flowering plants exhibit may have evolved as defenses against herbivorous insects.
Michael Ashburner was an English biologist and Emeritus Professor in the Department of Genetics at University of Cambridge. He was also the former joint-head and co-founder of the European Bioinformatics Institute (EBI) of the European Molecular Biology Laboratory and a Fellow of Churchill College,Cambridge.
The Anopheles gambiae complex consists of at least seven morphologically indistinguishable species of mosquitoes in the genus Anopheles. The complex was recognised in the 1960s and includes the most important vectors of malaria in sub-Saharan Africa,particularly of the most dangerous malaria parasite,Plasmodium falciparum. It is one of the most efficient malaria vectors known. The An. gambiae mosquito additionally transmits Wuchereria bancrofti which causes lymphatic filariasis,a symptom of which is elephantiasis.
Edward Fred Knipling was an American entomologist,who along with his longtime colleague Raymond C. Bushland,received the 1992 World Food Prize for their collaborative achievements in developing the sterile insect technique for eradicating or suppressing the threat posed by pests to the livestock and crops that contribute to the world's food supply. Knipling's contributions included the parasitoid augmentation technique,insect control methods involving the medication of the hosts,and various models of total insect population management. Knipling was best known as the inventor of the sterile insect technique (SIT),an autocidal theory of total insect population management. The New York Times Magazine proclaimed on January 11,1970,that "Knipling...has been credited by some scientists as having come up with 'the single most original thought in the 20th century.'"
FlyBase is an online bioinformatics database and the primary repository of genetic and molecular data for the insect family Drosophilidae. For the most extensively studied species and model organism,Drosophila melanogaster,a wide range of data are presented in different formats.
Forensic entomology has three sub-fields:urban,stored product and medico-criminal entomologies. This article focuses on medico-criminal entomology and how DNA is analyzed with various blood-feeding insects.
Psocodea is a taxonomic group of insects comprising the bark lice,book lice and parasitic lice. It was formerly considered a superorder,but is now generally considered by entomologists as an order. Despite the greatly differing appearance of parasitic lice (Phthiraptera),they are believed to have evolved from within the former order Psocoptera,which contained the bark lice and book lice,now found to be paraphyletic. They are often regarded as the most primitive of the hemipteroids. Psocodea contains around 11,000 species,divided among four suborders and more than 70 families. They range in size from 1–10 millimetres (0.04–0.4 in) in length.
Insects are pancrustacean hexapod invertebrates of the class Insecta. They are the largest group within the arthropod phylum. Insects have a chitinous exoskeleton,a three-part body,three pairs of jointed legs,compound eyes and one pair of antennae. Their blood is not totally contained in vessels;some circulates in an open cavity known as the haemocoel. Insects are the most diverse group of animals;they include more than a million described species and represent more than half of all known living organisms. The total number of extant species is estimated at between six and ten million;potentially over 90% of the animal life forms on Earth are insects. Insects may be found in nearly all environments,although only a small number of species reside in the oceans,which are dominated by another arthropod group,crustaceans,which recent research has indicated insects are nested within.
A genetically modified (GM) insect is an insect that has been genetically modified,either through mutagenesis,or more precise processes of transgenesis,or cisgenesis. Motivations for using GM insects include biological research purposes and genetic pest management. Genetic pest management capitalizes on recent advances in biotechnology and the growing repertoire of sequenced genomes in order to control pest populations,including insects. Insect genomes can be found in genetic databases such as NCBI,and databases more specific to insects such as FlyBase,VectorBase,and BeetleBase. There is an ongoing initiative started in 2011 to sequence the genomes of 5,000 insects and other arthropods called the i5k. Some Lepidoptera have been genetically modified in nature by the wasp bracovirus.
Drosophila suzukii,commonly called the spotted wing drosophila or SWD,is a fruit fly. D. suzukii,originally from southeast Asia,is becoming a major pest species in America and Europe,because it infests fruit early during the ripening stage,in contrast with other Drosophila species that infest only rotting fruit.
Pthirus gorillae or gorilla louse is a species of parasitic sucking louse that afflicts gorillas. It is found in the African continent,specifically in Rwanda and Democratic Republic of the Congo. P. gorillae and P. pubis are the only known species that belong to the genus Pthirus,often incorrectly spelled as Phthirus. It is suggested that it is transmitted among its hosts by social grooming,shared bedding and sexual contact.
Ronald J. Konopka (1947-2015) was an American geneticist who studied chronobiology. He made his most notable contribution to the field while working with Drosophila in the lab of Seymour Benzer at the California Institute of Technology. During this work,Konopka discovered the period (per) gene,which controls the period of circadian rhythms.
Christos Louis,nicknamed Kitsos,is a Greek Molecular Geneticist. He graduated from the Medical School of the University of Marburg in 1974 and joined the team of Prof. C.E. Sekeris,first at Marburg and then at the German Cancer Research Center Heidelberg,obtaining his doctoral degree in Cell biology from Heidelberg University in 1977. His work focuses on Genomics and Bioinformatics of insects and vector-borne/tropical diseases.
The Morganellaceae are a family of Gram-negative bacteria that include some important human pathogens formerly classified as Enterobacteriaceae. This family is a member of the order Enterobacterales in the class Gammaproteobacteria of the phylum Pseudomonadota. Genera in this family include the type genus Morganella,along with Arsenophonus,Cosenzaea,Moellerella,Photorhabdus,Proteus,Providencia and Xenorhabdus.
Cyp6g1 or DDT-R is an insecticide resistance gene for resistance to DDT in Drosophila melanogaster. It belongs to the cytochrome P450 family and is located in chromosome 2R. Following up their earlier work,Daborn et al 2002 find the DDT-R gene induces overtranscription of Cyp6g1,of which there are 4 duplicates. They also find several substrates of Cyp6g1,namely DDT,lufenuron,and nitenpyram.
Cytochrome P450,family 6,also known as CYP6,is a cytochrome P450 family found in Insect genome. CYP6 and CYP9,another insect CYP family,belong to the same clan as mammalian CYP3 and CYP5 families.