Body surface area

In physiology and medicine, the body surface area (BSA) is the measured or calculated surface area of a human body. For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index, such as chemotherapy.

Typically there is a 4–10 fold variation in drug clearance between individuals due to differing the activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and underdosing (and increased risk of disease recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. ^{[1] [2]} The trend to personalized medicine is one approach to counter this weakness.

Uses

Examples of uses of the BSA:

• Renal clearance usually divided by the BSA i.e. per 1.73 m² to gain an appreciation of the true glomerular filtration rate (GFR);
• The Quetelet index uses a somewhat modified form of the BSA;
• The cardiac index is a measure of cardiac output divided by the BSA, giving a better approximation of the effective cardiac output;
• Chemotherapy is often dosed according to the patient's BSA.
• Glucocorticoid dosing is also expressed in terms of BSA for calculating maintenance doses or to compare high dose use with maintenance requirement.

There is some evidence that BSA values are less accurate at extremes of height and weight, where Body Mass Index may be a better estimate (for hemodynamic parameters). ^[3]

Calculation

Various calculations have been published to arrive at the BSA without direct measurement. In the following formulae, BSA is expressed in m ², weight (or, more properly, mass) W in kg, and height H in cm.

The most widely used is the Du Bois formula, ^{[4] [5]} which has been shown to be equally as effective in estimating body fat in obese and non-obese patients, something the Body mass index fails to do. ^[6]

${\displaystyle {BSA}=0.007184\times W^{0.425}\times H^{0.725}}$

The Mosteller formula is also commonly used, and is mathematically simpler: ^[7]

${\displaystyle {BSA}={\frac {\sqrt {W\times H}}{60}}=0.016667\times W^{0.5}\times H^{0.5}}$

Other formulas for BSA in m² include:

Haycock [8]	${\displaystyle 0.024265\times W^{0.5378}\times H^{0.3964}}$
Gehan and George [9]	${\displaystyle 0.0235\times W^{0.51456}\times H^{0.42246}}$
Boyd [10]	${\displaystyle 0.03330\times W^{(0.6157-0.0188\log _{10}{W})}\times H^{0.3}}$
or alternatively	${\displaystyle 0.0003207\times \mathrm {weight} \mathrm {(g)} ^{(0.7285-0.0188\log _{10}{\mathrm {weight} \mathrm {(g)} })}\times H^{0.3}}$
Fujimoto [11]	${\displaystyle 0.008883\times W^{0.444}\times H^{0.663}}$
Takahira [11]	${\displaystyle 0.007241\times W^{0.425}\times H^{0.725}}$
Shuter and Aslani [12]	${\displaystyle 0.00949\times W^{0.441}\times H^{0.655}}$
Lipscombe [13]	${\displaystyle 0.00878108\times W^{0.434972}\times H^{0.67844}}$
Schlich [14]	${\displaystyle 0.000975482\times W^{0.46}\times H^{1.08}}$    (women)
	${\displaystyle 0.000579479\times W^{0.38}\times H^{1.24}}$    (men)

For any formula, the units should match. Mosteller pointed out that his formula holds only if the density is treated as a constant for all humans. Lipscombe, following Mosteller's reasoning, observed that the formulas obtained by Fujimoto, Shuter and Aslani, Takahira, and Lipscombe are suggestive of ${\displaystyle {8/900}\times W^{4/9}\times H^{2/3}}$, which is dimensionally correct for the case of constant density. It equals ${\displaystyle (2^{3}/3^{2})\times (W^{2/3}H)^{2/3}/100}$.

A weight-based formula that does not include a square root (making it easier to use) was proposed by Costeff and recently validated for the pediatric age group. It is [4W (kg) + 7]/[90 + W (kg)]. ^{[15] [16]}

Average values

Average BSA for children of various ages, for men, and for women, can be estimated using statistical survey data and a BSA formula: ^[17]

Mean male BSA by age

Age or age group	metric		imperial
Neonate (newborn)	0.243	m2	2.612	ft2
2 years	0.563	m2	6.060	ft2
5 years	0.787	m2	8.471	ft2
10 years	1.236	m2	13.304	ft2
13 years	1.603	m2	17.255	ft2
18 years	1.980	m2	21.313	ft2
20–79 years	2.060	m2	22.173	ft2
80+ years	1.920	m2	20.667	ft2

Mean female BSA by age

Age or age group	metric		imperial
Neonate (newborn)	0.234	m2	2.519	ft2
2 years	0.540	m2	5.813	ft2
5 years	0.771	m2	8.299	ft2
10 years	1.245	m2	13.401	ft2
13 years	1.550	m2	16.684	ft2
18 years	1.726	m2	18.579	ft2
20–79 years	1.830	m2	19.697	ft2
80+ years	1.638	m2	17.631	ft2

The estimations in the above tables are based weight and height data from the U.S. NCHS National Health and Nutrition Examination Survey (2011-2014). ^[18]

There was an average BSA of 1.73 m² for 3,000 cancer patients from 1990 to 1998 in a European Organisation for Research and Treatment of Cancer (EORTC) database. ^[19]

During 2005 there was an average BSA of 1.79 m² for 3,613 adult cancer patients in the UK. Among them the average BSA for men was 1.91 m² and for women was 1.71 m². ^[20]

References

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2. Gao B, Klumpen HJ, Gurney H (October 2008). "Dose calculation of anticancer drugs". Expert Opin Drug Metab Toxicol. 4 (10): 1307–19. doi:10.1517/17425255.4.10.1307. PMID   18798700. S2CID   73327796.
3. Adler, AC; Nathanson, BH; Raguhunathan, K; McGee, WT (2012). "Misleading indexed hemodynamic parameters: the clinical importance of discordant BMI and BSA at extremes of weight". Critical Care. 16 (6): 471. doi: 10.1186/cc11876 . PMC   3672608 . PMID   23273020.
4. Du Bois D, Du Bois EF (Jun 1916). "A formula to estimate the approximate surface area if height and weight be known". Archives of Internal Medicine. 17 (6): 863–71. doi:10.1001/archinte.1916.00080130010002. Reprinted in PMID   2520314
5. Verbraecken, J; Van de Heyning P; De Backer W; Van Gaal L (Apr 2006). "Body surface area in normal-weight, overweight, and obese adults. A comparison study" . Metabolism: Clinical and Experimental. 55 (4): 515–24. doi:10.1016/j.metabol.2005.11.004. PMID   16546483 . Retrieved 2012-09-07.
6. Sardinha, LB; Silva, AM; Minderico, CS; Teixeira, PJ (2006). "Effect of body surface area calculations on body fat estimates in non-obese and obese subjects". Physiological Measurement. 27 (11): 1197–209. Bibcode:2006PhyM...27.1197S. doi:10.1088/0967-3334/27/11/012. PMID   17028412. S2CID   12141324.
7. Mosteller, RD (1987). "Simplified calculation of body-surface area". N Engl J Med . 317 (17): 1098. doi:10.1056/NEJM198710223171717. PMID   3657876.
8. Haycock, GB; Schwartz, GJ; Wisotsky, DH (1978). "Geometric method for measuring body surface area: A height-weight formula validated in infants, children and adults". J Pediatr. 93 (1): 62–66. doi:10.1016/s0022-3476(78)80601-5. PMID   650346.
9. Gehan EA, George SL, Cancer Chemother Rep 1970, 54:225-235
10. Boyd, Edith (1935). The Growth of the Surface Area of the Human Body. University of Minnesota. The Institute of Child Welfare, Monograph Series, No. x. London: Oxford University Press.
11. Fujimoto, S; Watanabe, T; Sakamoto, A; Yukawa, K; Morimoto, K (1968). "Studies on the physical surface area of Japanese. 18. Calculation formulae in three stages over all ages". Nippon Eiseigaku Zasshi. 23 (5): 443–50. doi: 10.1265/jjh.23.443 . PMID   5752712.
12. Shuter, B; Aslani, A (2000). "Body surface area: Du bois and Du bois revisited". European Journal of Applied Physiology. 82 (3): 250–254. doi:10.1007/s004210050679. PMID   10929220. S2CID   25764872.
13. Lipscombe, Trevor, Body Surface Area Formula by Use of Geometric Means Medicina Internacia Revuo 2020, 29 (114):11-18
14. Schlich, E; Schumm, M; Schlich, M (2010). "3-D-Body-Scan als anthropometrisches Verfahren zur Bestimmung der spezifischen Körperoberfläche". Ernährungs Umschau . 57 (4): 178–183.
15. Costeff H, "A simple empirical formula for calculating approximate surface area in children.," Arch Dis Child, vol. 41, no. 220, pp. 681–683, Dec. 1966.
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17. Georgiev, Georgi. "Body Surface Area Calculator". Gigacalculator.com. Retrieved 17 March 2018.
18. "National Health and Nutrition Examination Survey". Cdc.gov. Retrieved 2018-03-17.
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