Brian Stoltz

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Brian Stoltz
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Born
Brian M. Stoltz

(1970-11-12) November 12, 1970 (age 54)
Nationality American
Alma mater Indiana University of Pennsylvania (B.S., 1993)
Yale (Ph.D., 1997)
Awards Fellow of the American Association for the Advancement of Science
Scientific career
Fields Chemistry
Institutions California Institute of Technology
Doctoral advisor John L. Wood
Other academic advisors E. J. Corey
Doctoral students
Website www.cce.caltech.edu/content/brian-m-stoltz OOjs UI icon edit-ltr-progressive.svg

Brian M. Stoltz is currently a professor of chemistry at the California Institute of Technology. [2] The primary focus of his research is chemical synthesis with an emphasis on developing allylic alkylation reactions for the preparation of complex molecules possessing unique structural, biological, and physical properties. His research involves the total synthesis of natural products such as dragmacidin F [3] and (–)-cyanthiwigin F, [4] and development of synthetic reactions to access quaternary stereocenters. [5] Specifically, he has focused on the allylic alkylation of enolates, developing an enantioselective variant in 2004. [6]

Contents

Education

Stoltz received undergraduate degrees in Chemistry and German from Indiana University of Pennsylvania in 1993. As an undergraduate he spent a year abroad at the Ludwig Maximilian University of Munich. He went on to earn his M.S. and Ph.D. at Yale University, [7] where he studied organic chemistry under the supervision of John L. Wood, completing his studies in 1997. Upon completion of his graduate work, he held an NIH post-doctoral fellowship appointment in the laboratory of E. J. Corey at Harvard University from 1998 to 2000.

Career and research

Stoltz began his independent career at Caltech in 2000. He was promoted to Associate Professor in 2006 and then to Full Professor in 2007. His laboratory is well-known for their achievements in total synthesis and methods development. Some of the achievements from his lab included the syntheses of cylandrocyclophane, [8] jorunnamycin A, [9] and cyanthawigin F. [4] His lab also solved long-standing challenges, such as completing the synthesis of 2-quinuclidonium tetrafluoroborate. [10] Stoltz is a leader in organometallic chemistry and has developed numerous methods, [11] especially allylic alkylation chemistry. [6] He is the Editor-in-Chief of Tetrahedron. At present[ when? ] he is also an associate editor for the Beilstein Journal of Organic Chemistry . [12]

Awards and honors

References

  1. ↑ Nelson, Hosea (2013). A Unified Synthetic Approach to the Transtaganolide and Basiliolide Natural Products. caltech.edu (PhD thesis). California Institute of Technology. doi:10.7907/09DW-P586. OCLC   1014495702.
  2. ↑ "Brian M. Stoltz". stoltz.caltech.edu. Archived from the original on July 9, 2015. Retrieved August 19, 2015.
  3. ↑ Garg, Neil K.; Caspi, Daniel D.; Stoltz, Brian M. (July 20, 2004). "The Total Synthesis of (+)-Dragmacidin F" (PDF). Journal of the American Chemical Society. 126 (31): 9552–9553. Bibcode:2004JAChS.126.9552G. doi:10.1021/ja046695b. PMID   15291554.
  4. 1 2 Enquist, John A.; Stoltz, Brian M. (May 2, 2008). "The total synthesis of (-)-cyanthiwigin F by means of double catalytic enantioselective alkylation". Nature. 453 (7199): 1228–1231. Bibcode:2008Natur.453.1228E. doi:10.1038/nature07046. PMC   2474750 . PMID   18580947.
  5. ↑ "Press release: Potassium Salt Outperforms Precious Metals As a Catalyst | Caltech". The California Institute of Technology. February 4, 2015.
  6. 1 2 Stoltz, Brian; Behenna, Douglas (October 28, 2004). "The Enantioselective Tsuji Allylation" (PDF). J. Am. Chem. Soc. 126 (46): 15044–15045. Bibcode:2004JAChS.12615044B. doi:10.1021/ja044812x. PMID   15547998.
  7. ↑ "ACS Award for Creative Work in Synthetic Organic Chemistry: Brian M. Stoltz". C&EN Global Enterprise. 96 (2): 49. 2018-01-08. doi: 10.1021/cen-09602-awards50 . ISSN   2474-7408.
  8. ↑ Bosse, Aaron T.; Hunt, Liam R.; Suarez, Camila A.; Casselman, Tyler D.; Goldstein, Elizabeth L.; Wright, Austin C.; Park, Hojoon; Virgil, Scott C.; Yu, Jin-Quan; Stoltz, Brian M.; Davies, Huw M. L. (2024-11-08). "Total synthesis of (−)-cylindrocyclophane A facilitated by C−H functionalization". Science. 386 (6722): 641–646. Bibcode:2024Sci...386..641B. doi:10.1126/science.adp2425. PMC  11648813. PMID   39509484.
  9. ↑ Welin, Eric R.; Ngamnithiporn, Aurapat; Klatte, Max; Lapointe, Guillaume; Pototschnig, Gerit M.; McDermott, Martina S. J.; Conklin, Dylan; Gilmore, Christopher D.; Tadross, Pamela M.; Haley, Christopher K.; Negoro, Kenji; Glibstrup, Emil; Grünanger, Christian U.; Allan, Kevin M.; Virgil, Scott C. (2019-01-18). "Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis". Science. 363 (6424): 270–275. Bibcode:2019Sci...363..270W. doi:10.1126/science.aav3421. PMC   7017906 . PMID   30573544.
  10. ↑ Tani, Kousuke; Stoltz, Brian M. (June 2006). "Synthesis and structural analysis of 2-quinuclidonium tetrafluoroborate". Nature. 441 (7094): 731–734. Bibcode:2006Natur.441..731T. doi:10.1038/nature04842. ISSN   1476-4687. PMID   16760973.
  11. ↑ "Reaction Development". The Stoltz Group. Retrieved 2025-09-03.
  12. ↑ Beilstein Journal of Organic Chemistry Prof. Brian M. Stoltz
  13. ↑ Cottle, Sara (2025-01-21). "ACS announces 2026 national award winners". Chemical & Engineering News. Retrieved 2025-09-02.
  14. ↑ "American Chemical Society, Award for Creative Work in Synthetic Organic Chemistry". C&EN Global Enterprise. 96 (2). acs.org: 49. 8 January 2018. doi: 10.1021/cen-09602-awards50 .
  15. ↑ "Brian Stoltz Receives 2015 Mukaiyama Award". caltech.edu. October 1, 2014. Archived from the original on March 17, 2015. Retrieved August 31, 2015.
  16. ↑ "Alumnus Stoltz Honored with Tetrahedron Young Investigator Award". iup.edu. February 24, 2010. Retrieved August 31, 2015.
  17. ↑ "Past Laureates of the Raymond and Beverly Sackler International Prize in the Physical Sciences". 5 September 2012.
  18. ↑ "Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis by a Young Investigator" . Retrieved September 3, 2015.
  19. ↑ "NSF Award Recipient Details". nsf.gov. Retrieved August 31, 2015.
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