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Bruce Eliot Maryanoff FRSC (born February 26, 1947, in Philadelphia, Pennsylvania) is an American medicinal and organic chemist.
Maryanoff received a B.S. degree in chemistry in 1969, and a PhD degree in organic chemistry in 1972, both from Drexel University. [1] From 1972 to 1974 Maryanoff was a postdoctoral fellow in the department of chemistry at Princeton University. He joined McNeil Laboratories, Inc., a Johnson & Johnson subsidiary, in 1974 and advanced on the scientific ladder in various Johnson & Johnson pharmaceutical units to the highest scientific position in the company. Maryanoff retired from Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania, in January 2010. He is now affiliated with The Scripps Research Institute, La Jolla, California and is a Distinguished Professor at the Baruch S. Blumberg Institute, Doylestown, Pennsylvania. He served as associate editor for the journal ACS Medicinal Chemistry Letters from 2009-2020. He is married to Dr. Cynthia A. Maryanoff.
Maryanoff has been active in the fields of medicinal chemistry and organic chemistry. He is an inventor of topiramate, [2] a unique sugar sulfamate drug, which has been marketed worldwide for the treatment of epilepsy and migraine, attaining annual sales of more than $2 billion. [3] Topiramate is also a principal component of the antiobesity drug Qsymia. [4] Maryanoff is an internationally renowned expert in drug design and drug discovery, especially in the application of protein structure-based drug design. He made seminal contributions to understanding the stereochemistry and mechanism of the Wittig reaction; adapted the cobalt-catalyzed alkyne trimerization to the synthesis of macrocycles; and devised novel peptides that undergo self-assembly to mimic native collagen structurally and functionally. Maryanoff is an author on 280 scientific publications, including several books (editor), book chapters, and review articles. He is an inventor on 100 issued U.S. patents, has presented over 185 invited lectures worldwide, and mentored 11 postdoctoral associates. Maryanoff organized and edited a special memorial issue of the Journal of Medicinal Chemistry to honor the memory of Dr. Paul Janssen (2005) [5] and has served on numerous editorial advisory boards for scientific journals and research grant review committees.
Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. It has also been used in alcohol dependence and essential tremor. For epilepsy this includes treatment for generalized or focal seizures. It is taken orally.
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio.
David A. Evans was an American chemist who was the Abbott and James Lawrence professor of chemistry at Harvard University. He was a prominent figure in the field of organic chemistry and his research focused on synthetic chemistry and total synthesis, particularly of large biologically active molecules. Among his best-known works is the development of aldol reaction methodology.
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Kendall Newcomb Houk is a Distinguished Research Professor in Organic Chemistry at the University of California, Los Angeles. His research group studies organic, organometallic, and biological reactions using the tools of computational chemistry. This work involves quantum mechanical calculations, often with density functional theory, and molecular dynamics, either quantum dynamics for small systems or force fields such as AMBER, for solution and protein simulations.
Donna J. Nelson is an American chemist and professor of chemistry at the University of Oklahoma. Nelson specializes in organic chemistry, which she both researches and teaches. Nelson served as a science advisor to the AMC television show Breaking Bad. She was the 2016 President of the American Chemical Society (ACS) with her presidential activities focusing on and guided by communities in chemistry. Nelson's research focused on five primary topics, generally categorized in two areas, Scientific Research and America's Scientific Readiness. Within Scientific Research, Nelson's topics have been on mechanistic patterns in alkene addition reactions and on Single-Walled Carbon Nanotube (SWCNT) functionalization and analysis, yielding the first COSY NMR spectrum of covalently functionalized SWCNTs in solution. Under America's Scientific Readiness, she focuses on science education and impacting science by considering its communities; this includes classroom innovations and correcting organic chemistry textbook inaccuracies, on ethnic and gender diversity among highly ranked science departments of research universities, and on improving the image and presentation of science and scientists to the public.
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Bruce D. Roth is an American organic and medicinal chemist who trained at Saint Joseph's College, Iowa State University and the University of Rochester, and, at the age of 32, discovered atorvastatin, the statin-class drug sold as Lipitor that would become the largest-selling drug in pharmaceutical history. His honours include being named a 2008 Hero of Chemistry by the American Chemical Society, and being chosen as the Perkin Medal awardee, the highest honour given in the U.S. chemical industry, by the Society of Chemical Industry, American section in 2013.
Peter John Stang is a German American chemist and Distinguished Professor of chemistry at the University of Utah. He was the editor-in-chief of the Journal of the American Chemical Society from 2002 to 2020.
Cynthia "Cyndie" Anne Maryanoff is an American organic and materials chemist. Among other awards, she received the 2015 Perkin Medal for outstanding work in applied chemistry in the U.S.A.
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Robert Owen Hutchins was an American organic chemist and educator. Born in Danville, Illinois, Hutchins earned a B.S. degree from the University of California at Berkeley in 1961, an M.A. degree in phytochemistry from California State University, Long Beach in 1962, and a Ph.D. degree in organic chemistry from Purdue University under Joseph Wolinsky in 1967. He then completed a two-year post-doctoral research position with Ernest L. Eliel at Notre Dame University,
This is a list of women chemists. It should include those who have been important to the development or practice of chemistry. Their research or application has made significant contributions in the area of basic or applied chemistry.
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Donna M. Huryn is an American medicinal and organic chemist. She received her B.A. (chemistry) from Cornell University, and Ph.D. in organic chemistry from the University of Pennsylvania. She is on the faculty at the University of Pittsburgh’s school of pharmacy, holds an adjunct appointment in the department of chemistry at the University of Pennsylvania, is the principal investigator of the University of Pittsburgh Chemical Diversity Center, and was a visiting fellow in the summer of 2017 at the University of Bologna. She is a fellow of the American Chemical Society, recipient of the ACS Philadelphia Local Section Award, has held a number of elected positions within the American Chemical Society at both the local and national levels, and is 2015 Chair of the Division of Organic Chemistry. Huryn also formed, along with a number of other scientists, the Empowering Women in Organic Chemistry Conferences in 2019. The goal was to empower and bring the research and career of all marginalized individuals in chemistry-related fields to the forefront of the scientific community. Huryn noticed how there was not enough women pursuing and maintaining a career in organic chemistry, and thus founded this organization. The Empowering Women in Organic Chemistry Conferences allowed for women leaders to present their scientific findings and hear the stories of how eminent women in the field of organic chemistry overcame the challenges they faced being female. She is associate editor of ACS Medicinal Chemistry Letters. She in also an editor of the journal Organic Reactions and co-authored the textbook Medicinal Chemistry and the article "Medicinal Chemistry: Where Are All the Women?" which appeared in the ACS Medicinal Chemistry Letters Journal. Huryn’s research focuses on the design and synthesis of small molecules probes and drugs to treat cancer, neurodegenerative and infectious diseases.
Iwao Ojima is a Japanese-American chemist and university distinguished professor at the State University of New York at Stony Brook. He has been widely recognized for his seminal contributions to a range of chemical research at the multifaceted interfaces of chemical synthesis and life sciences. As rare accomplishments, he has received four National Awards from the American Chemical Society in four different fields of research. He is also serving as the director of the Institute of Chemical Biology and Drug Discovery (ICB&DD), as well as the president of the Stony Brook Chapter of the National Academy of Inventors.
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