In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from Latin ligare, which means 'to bind'. In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. The binding typically results in a change of conformational isomerism (conformation) of the target protein. In DNA-ligand binding studies, the ligand can be a small molecule, ion, or protein which binds to the DNA double helix. The relationship between ligand and binding partner is a function of charge, hydrophobicity, and molecular structure.
Chemical Reviews is peer-reviewed scientific journal published twice per month by the American Chemical Society. It publishes review articles on all aspects of chemistry. It was established in 1924 by William Albert Noyes. The editor-in-chief is Sharon Hammes-Schiffer.
The Journal of Biological Chemistry (JBC) is a weekly peer-reviewed scientific journal that was established in 1905. Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in areas of biochemistry and molecular biology. The editor is Alex Toker. As of January 2021, the journal is fully open access. In press articles are available free on its website immediately after acceptance.
Inorganic Chemistry is a biweekly peer-reviewed scientific journal published by the American Chemical Society since 1962. It covers research in all areas of inorganic chemistry.
Organometallics is a biweekly journal published by the American Chemical Society. Its area of focus is organometallic and organometalloid chemistry. This peer-reviewed journal has an impact factor of 3.837 as reported by the 2021 Journal Citation Reports by Thomson Reuters.
The Journal of Labelled Compounds and Radiopharmaceuticals is a peer-reviewed scientific journal that was established in 1965. It is published in fourteen issues per year by John Wiley & Sons on behalf of the International Isotope Society and covers all aspects of research and development leading to and resulting in labelled compound preparation. The current editor-in-chiefs are R F Dannals and V Derdau.
Phytotherapy Research is a monthly peer-reviewed scientific journal publishing original research papers, short communications, reviews, and letters on medicinal plant research. Key areas of interest are pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine, from case histories to full clinical trials, including studies of herb-drug interactions and other aspects of the safety of herbal medicines. Papers concerned with the effects of common food ingredients and standardised plant extracts, including commercial products, are particularly relevant, as are mechanistic studies on isolated natural products.
Journal of Biological Inorganic Chemistry is a peer-reviewed scientific journal. It is an official publication of the Society of Biological Inorganic Chemistry and published by Springer Science+Business Media.
ACS Medicinal Chemistry Letters is a monthly peer-reviewed scientific journal covering medicinal chemistry. It was established in 2009 and is published by the American Chemical Society. The editor-in-chief is Dennis C. Liotta.
Planta Medica is a peer-reviewed journal published by Thieme Medical Publishers and covers medicinal plants and bioactive natural products of natural origin. Planta Medica is the official journal of the Society for Medicinal Plant and Natural Product Research (GA). According to the Journal Citation Reports, the journal's 2016 impact factor is 2.342. Planta Medica is a Q1 journal in integrative and complementary medicine, and a Q2 journal in plant sciences.
Chemical Science is a weekly peer-reviewed scientific journal covering all aspects of chemistry. It is the flagship journal of the Royal Society of Chemistry. It was established in July 2010 and is published by the Royal Society of Chemistry; before 2018, it was published monthly. It won the Best New Journal 2011 award from the Association of Learned and Professional Society Publishers. The editor-in-chief is Andrew Ian Cooper.
MedChemComm is a peer-reviewed scientific journal publishing original (primary) research and review articles on all aspects of medicinal chemistry, including drug discovery, pharmacology and pharmaceutical chemistry. Until December 2019, it was published monthly by the Royal Society of Chemistry in partnership with the European Federation for Medicinal Chemistry, of which it was the official journal. Authors can elect to have accepted articles published as open access. According to the Journal Citation Reports, the journal has a 2014 impact factor of 2.495, ranking it 27th out of 59 journals in the category "Chemistry, Medicinal" and 163 out of 289 journals in the category "Biochemistry & Molecular Biology".
Philip Salvatore Portoghese is an American medicinal chemist who has made notable contributions to the design and synthesis of ligands targeting opioid receptors. He is a Distinguished Professor of Medicinal Chemistry at the University of Minnesota, Twin Cities. He also served as the Editor-in-chief of the Journal of Medicinal Chemistry from 1972 to 2012, when the job was taken on by his departmental colleague, Gunda I. Georg, who shares the Editor-in-chief position with Shaomeng Wang at the University of Michigan.
Current Cancer Drug Targets is a peer-reviewed medical journal published by Bentham Science Publishers. The editor-in-chief is Ruiwen Zhang. The journal covers research on contemporary molecular drug targets involved in cancer, including medicinal chemistry, pharmacology, molecular biology, genomics, and biochemistry. Current Cancer Drug Targets publishes original research reports, review papers, and rapid communications ("letters").
Current Medicinal Chemistry is a peer-reviewed medical journal published by Bentham Science Publishers. The editor-in-chief is Atta-ur-Rahman, FRS. The journal covers developments in medicinal chemistry and rational drug design and publishes original research reports and review papers.
Current Topics in Medicinal Chemistry is a biweekly peer-reviewed medical journal published by Bentham Science Publishers. It includes review articles on all aspects of medicinal chemistry, including drug design. The current editor-in-chief is Jia Zhou.
Combinatorial Chemistry & High Throughput Screening is a peer-reviewed scientific journal that covers combinatorial chemistry. It was established in 1998 and is published by Bentham Science Publishers. The editor-in-chief is Gerald H. Lushington. The journal has 5 sections: Combinatorial/ Medicinal Chemistry, Chemo/Bio Informatics, High Throughput Screening, Pharmacognosy, and Laboratory Automation.
Mini-Reviews in Medicinal Chemistry is a monthly peer-reviewed medical journal covering all aspects of medicinal chemistry. It is published by Bentham Science Publishers and the editors-in-chief are Atta-ur-Rahman, M. Iqbal Choudhary, and George Perry.
Future Medicinal Chemistry is a peer-reviewed medical journal covering all aspects of medicinal chemistry, including drug discovery, pharmacology, in silico drug design, structural characterization techniques, ADME-Tox investigations, and science policy, economic and intellectual property issues. It was established in 2009 and is published by Future Science. The editors-in-chief are Iwao Ojima and Jonathan Baell.
Anti-Cancer Agents in Medicinal Chemistry is a peer-reviewed academic journal covering the disciplines of medicinal chemistry and drug design relating to chemotherapeutic agents in cancer. It is published by Bentham Science Publishers and the editor-in-chief is Simone Carradori. The journal covers developments in "medicinal chemistry and rational drug design for the discovery of anti-cancer agents" and publishes original research reports and review papers.
