Shaomeng Wang

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Shaomeng Wang is a Chinese-American chemist currently the Warner-Lambert/Parke-Davis Professor in Medicine at University of Michigan [1] and a former Co-Editor-in-Chief at American Chemical Society's Journal of Medicinal Chemistry . A cited expert in his field, [2] his interests are synthesis and design of moleculars, neurological diseases and computational and informatics. [1] He was Elected as Fellow at the National Academy of Inventors in 2014. [3] Dr. Wang was named to the AAAS Fellows Section on Pharmaceutical Sciences in 2019, [4] and is the recipient of the Division of Medicinal Chemistry Award 2020 American Chemical Society. [5]

Contents

Education

He earned his B.S. in Chemistry at Peking University and his Ph.D at Case Western Reserve University. He later began teaching at Georgetown University and University of Michigan Medical School. [6]

Publications

Compounds developed by Shaomeng Wang

References

  1. 1 2 "Shaomeng Wang". umich.edu. 23 December 2014. Retrieved November 27, 2017.
  2. ↑ "Shaomeng Wang" . Retrieved November 27, 2017.
  3. ↑ "UoM Professors Elected". umich.edu. Retrieved November 27, 2017.
  4. ↑ "The American Association for the Advancement of Science".
  5. ↑ "The Division of Medicinal Chemistry Award, Sponsored by the Thomas J. Perun Endowment Fund".
  6. ↑ "Shaomeng Wang". umich.edu. Retrieved November 27, 2017.
  7. ↑ Wang, Renxiao; Lu, Yipin; Wang, Shaomeng (2003-05-08). "Comparative Evaluation of 11 Scoring Functions for Molecular Docking" . Journal of Medicinal Chemistry. 46 (12): 2287–2303. doi:10.1021/jm0203783. ISSN   0022-2623. PMID   12773034.
  8. ↑ Shangary, Sanjeev; Qin, Dongguang; McEachern, Donna; Liu, Meilan; Miller, Rebecca S.; Qiu, Su; Nikolovska-Coleska, Zaneta; Ding, Ke; Wang, Guoping; Chen, Jianyong; Bernard, Denzil (2008-03-11). "Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition". Proceedings of the National Academy of Sciences. 105 (10): 3933–3938. Bibcode:2008PNAS..105.3933S. doi: 10.1073/pnas.0708917105 . ISSN   0027-8424. PMC   2268798 . PMID   18316739.
  9. ↑ Ding, Ke; Lu, Yipin; Nikolovska-Coleska, Zaneta; Wang, Guoping; Qiu, Su; Shangary, Sanjeev; Gao, Wei; Qin, Dongguang; Stuckey, Jeanne; Krajewski, Krzysztof; Roller, Peter P. (2006-06-01). "Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction" . Journal of Medicinal Chemistry. 49 (12): 3432–3435. doi:10.1021/jm051122a. ISSN   0022-2623. PMID   16759082.
  10. ↑ Wang, Renxiao; Fang, Xueliang; Lu, Yipin; Wang, Shaomeng (2004-06-03). "The PDBbind database: collection of binding affinities for protein-ligand complexes with known three-dimensional structures". Journal of Medicinal Chemistry. 47 (12): 2977–2980. doi:10.1021/jm030580l. ISSN   0022-2623. PMID   15163179.
  11. ↑ Ding, Ke; Lu, Yipin; Nikolovska-Coleska, Zaneta; Qiu, Su; Ding, Yousong; Gao, Wei; Stuckey, Jeanne; Krajewski, Krzysztof; Roller, Peter P.; Tomita, York; Parrish, Damon A. (2005-07-27). "Structure-based design of potent non-peptide MDM2 inhibitors". Journal of the American Chemical Society. 127 (29): 10130–10131. Bibcode:2005JAChS.12710130D. doi:10.1021/ja051147z. ISSN   0002-7863. PMID   16028899.
  12. ↑ Shangary, Sanjeev; Wang, Shaomeng (2009). "Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy". Annual Review of Pharmacology and Toxicology. 49: 223–241. doi:10.1146/annurev.pharmtox.48.113006.094723. ISSN   0362-1642. PMC   2676449 . PMID   18834305.
  13. ↑ Song, Hui; Wang, Renxiao; Wang, Shaomeng; Lin, Jiayuh (2005-03-29). "A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells". Proceedings of the National Academy of Sciences of the United States of America. 102 (13): 4700–4705. Bibcode:2005PNAS..102.4700S. doi: 10.1073/pnas.0409894102 . ISSN   0027-8424. PMC   555708 . PMID   15781862.
  14. ↑ Shaomeng Wang, et al. WO2006023778 (University of Michigan).
  15. ↑ Shaomeng Wang, et al. WO2010025235 (University of Michigan).
  16. ↑ Zhao, He; Neamati, Nouri; Hong, Huixiao; Mazumder, Abhijit; Wang, Shaomeng; Sunder, Sanjay; Milne, George W. A.; Pommier, Yves; Burke, Terrence R. (1997). "Coumarin-Based Inhibitors of HIV Integrase". Journal of Medicinal Chemistry. 40 (2): 242–249.  doi:10.1021/jm960450v.
  17. ↑ Mazumder, Abhijit; Wang, Shaomeng; Neamati, Nouri; Nicklaus, Marc; Sunder, Sanjay; Chen, Julie; Milne, George W. A.; Rice, William G.; Burke,, Terrence R.; Pommier, Yves (1996). "Antiretroviral Agents as Inhibitors of both Human Immunodeficiency Virus Type 1 Integrase and Protease". Journal of Medicinal Chemistry. 39 (13): 2472–2481.  doi:10.1021/jm960074e.
  18. ↑ Chen, Jianyong; Levant, Beth; Jiang, Cheng; Keck, Thomas M.; Newman, Amy Hauck; Wang, Shaomeng (2014). "Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D3 Receptor Antagonists". Journal of Medicinal Chemistry. 57 (11): 4962–4968. doi:10.1021/jm401798r
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