Bryan J. Traynor

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Bryan J. Traynor
Born (1969-08-12) August 12, 1969 (age 55)
Dublin, Ireland
CitizenshipIreland, United States
Alma mater University College Dublin (MB, MD, PhD)
Harvard–MIT Program in Health Sciences and Technology (MMSc)
Known forDiscovery of the C9orf72 repeat expansion
Awards Sheila Essey Award
Potamkin Prize
NIH Director's Award
Scientific career
FieldsAmyotrophic lateral sclerosis
frontotemporal dementia
genetics
gene therapy
InstitutionsNational Institute on Aging
Johns Hopkins University

Bryan J. Traynor is a neurologist and a senior investigator at the National Institute on Aging, and an adjunct professor at Johns Hopkins University. [1] Dr. Traynor studies the genetics of human neurological conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). He led the international consortium that identified pathogenic repeat expansions in the C9orf72 gene as a common cause of ALS and FTD. [2] Dr. Traynor also led efforts that identified other Mendelian genes responsible for familial ALS and dementia, including VCP, MATR3, KIF5A, HTT, and SPTLC1. [3] [4] [5] [6] [7]

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Dr. Traynor is a co-recipient of the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases for the discovery of the C9orf72 repeat expansions, and the Sheila Essay Award for his contributions to our understanding of ALS. He also received the NIH Director’s Award.

Education

Dr. Traynor received his medical degree (MB, BCh, BAO, 1993), his Medical Doctorate (MD, 2000), and his Doctor of Philosophy (PhD, 2012) from University College Dublin. He also received his Master of Medical Science (MMSc) in drug development and clinical trial design from Harvard-MIT HST in 2004. He completed his neurology residency and fellowship at Brigham and Women’s Hospital and Massachusetts General Hospital.

Awards, prizes, and honors

Notable professional service

References

  1. ↑ "Neuromuscular Diseases Research Section". National Institute on Aging. Retrieved 2019-03-26.
  2. ↑ Renton, Alan E.; Majounie, Elisa; Waite, Adrian; Simón-Sánchez, Javier; Rollinson, Sara; Gibbs, J. Raphael; Schymick, Jennifer C.; Laaksovirta, Hannu; van Swieten, John C.; Myllykangas, Liisa; Kalimo, Hannu; Paetau, Anders; Abramzon, Yevgeniya; Remes, Anne M.; Kaganovich, Alice; Scholz, Sonja W.; Duckworth, Jamie; Ding, Jinhui; Harmer, Daniel W.; Hernandez, Dena G.; Johnson, Janel O.; Mok, Kin; Ryten, Mina; Trabzuni, Danyah; Guerreiro, Rita J.; Orrell, Richard W.; Neal, James; Murray, Alex; Pearson, Justin; Jansen, Iris E.; Sondervan, David; Seelaar, Harro; Blake, Derek; Young, Kate; Halliwell, Nicola; Callister, Janis Bennion; Toulson, Greg; Richardson, Anna; Gerhard, Alex; Snowden, Julie; Mann, David; Neary, David; Nalls, Michael A.; Peuralinna, Terhi; Jansson, Lilja; Isoviita, Veli-Matti; Kaivorinne, Anna-Lotta; Hölttä-Vuori, Maarit; Ikonen, Elina; Sulkava, Raimo; Benatar, Michael; Wuu, Joanne; Chiò, Adriano; Restagno, Gabriella; Borghero, Giuseppe; Sabatelli, Mario; Heckerman, David; Rogaeva, Ekaterina; Zinman, Lorne; Rothstein, Jeffrey D.; Sendtner, Michael; Drepper, Carsten; Eichler, Evan E.; Alkan, Can; Abdullaev, Ziedulla; Pack, Svetlana D.; Dutra, Amalia; Pak, Evgenia; Hardy, John; Singleton, Andrew; Williams, Nigel M.; Heutink, Peter; Pickering-Brown, Stuart; Morris, Huw R.; Tienari, Pentti J.; Traynor, Bryan J. (2011). "A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD". Neuron. 72 (2): 257–268. doi:10.1016/j.neuron.2011.09.010. ISSN   0896-6273. PMC   3200438 . PMID   21944779.
  3. ↑ Johnson, Janel O.; Mandrioli, Jessica; Benatar, Michael; Abramzon, Yevgeniya; Van Deerlin, Vivianna M.; Trojanowski, John Q.; Gibbs, J. Raphael; Brunetti, Maura; Gronka, Susan; Wuu, Joanne; Ding, Jinhui; McCluskey, Leo; Martinez-Lage, Maria; Falcone, Dana; Hernandez, Dena G.; Arepalli, Sampath; Chong, Sean; Schymick, Jennifer C.; Rothstein, Jeffrey; Landi, Francesco; Wang, Yong-Dong; Calvo, Andrea; Mora, Gabriele; Sabatelli, Mario; Monsurrò, Maria Rosaria; Battistini, Stefania; Salvi, Fabrizio; Spataro, Rossella; Sola, Patrizia; Borghero, Giuseppe; Galassi, Giuliana; Scholz, Sonja W.; Taylor, J. Paul; Restagno, Gabriella; Chiò, Adriano; Traynor, Bryan J. (2010). "Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS". Neuron. 68 (5): 857–864. doi:10.1016/j.neuron.2010.11.036. ISSN   0896-6273. PMC   3032425 . PMID   21145000.
  4. ↑ Johnson, Janel O; Pioro, Erik P; Boehringer, Ashley; Chia, Ruth; Feit, Howard; Renton, Alan E; Pliner, Hannah A; Abramzon, Yevgeniya; Marangi, Giuseppe; Winborn, Brett J; Gibbs, J Raphael; Nalls, Michael A; Morgan, Sarah; Shoai, Maryam; Hardy, John; Pittman, Alan; Orrell, Richard W; Malaspina, Andrea; Sidle, Katie C; Fratta, Pietro; Harms, Matthew B; Baloh, Robert H; Pestronk, Alan; Weihl, Conrad C; Rogaeva, Ekaterina; Zinman, Lorne; Drory, Vivian E; Borghero, Giuseppe; Mora, Gabriele; Calvo, Andrea; Rothstein, Jeffrey D; Drepper, Carsten; Sendtner, Michael; Singleton, Andrew B; Taylor, J Paul; Cookson, Mark R; Restagno, Gabriella; Sabatelli, Mario; Bowser, Robert; Chiò, Adriano; Traynor, Bryan J (2014). "Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis". Nature Neuroscience. 17 (5): 664–666. doi:10.1038/nn.3688. ISSN   1097-6256. PMC   4000579 . PMID   24686783.
  5. ↑ Nicolas, Aude; Kenna, Kevin P.; Renton, Alan E.; Ticozzi, Nicola; Faghri, Faraz; Chia, Ruth; Dominov, Janice A.; Kenna, Brendan J.; Nalls, Mike A.; Keagle, Pamela; Rivera, Alberto M. (2018). "Genome-wide Analyses Identify KIF5A as a Novel ALS Gene". Neuron. 97 (6): 1268–1283.e6. doi:10.1016/j.neuron.2018.02.027. ISSN   1097-4199. PMC   5867896 . PMID   29566793.
  6. ↑ Dewan, Ramita; Chia, Ruth; Ding, Jinhui; Hickman, Richard A.; Stein, Thor D.; Abramzon, Yevgeniya; Ahmed, Sarah; Sabir, Marya S.; Portley, Makayla K.; Tucci, Arianna; Ibáñez, Kristina (2021). "Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis". Neuron. 109 (3): 448–460.e4. doi:10.1016/j.neuron.2020.11.005. ISSN   1097-4199. PMC   7864894 . PMID   33242422.
  7. ↑ Johnson, Janel O.; Chia, Ruth; Miller, Danny E.; Li, Rachel; Kumaran, Ravindran; Abramzon, Yevgeniya; Alahmady, Nada; Renton, Alan E.; Topp, Simon D.; Gibbs, J. Raphael; Cookson, Mark R.; Sabir, Marya S.; Dalgard, Clifton L.; Troakes, Claire; Jones, Ashley R. (2021-10-01). "Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis". JAMA Neurology. 78 (10): 1236–1248. doi:10.1001/jamaneurol.2021.2598. ISSN   2168-6157. PMC   8406220 . PMID   34459874.
  8. ↑ "Derek Denny-Brown Neurological Scholar Award | American Neurological Association (ANA)". myana.org. Retrieved 2019-03-26.
  9. ↑ "Wings Over Wall Street - Awards". wingsoverwallstreet.org. Retrieved 2019-03-26.
  10. ↑ "ALS Association".
  11. ↑ "American Academy of Neurology".
  12. ↑ "Irish America Magazine". November 2018.
  13. ↑ "Amyotrophic Lateral Sclerosis Research Program, Programmatic Panels; Congressionally Directed Medical Research Programs". cdmrp.army.mil. Archived from the original on March 26, 2019. Retrieved 2019-03-26.
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