C14orf180

Last updated
C14orf180
Identifiers
Aliases C14orf180 , C14orf77, NRAC, chromosome 14 open reading frame 180
External IDs MGI: 2443020 HomoloGene: 52221 GeneCards: C14orf180
Gene location (Human)
Ideogram human chromosome 14.svg
Chr. Chromosome 14 (human) [1]
Human chromosome 14 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 14q32.33Start104,579,684 bp [1]
End104,590,515 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001008404
NM_001286399
NM_001286400

NM_177039

RefSeq (protein)

NP_001008404
NP_001273328
NP_001273329

NP_796013

Location (UCSC) Chr 14: 104.58 – 104.59 Mb Chr 12: 112.49 – 112.5 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C14orf180 is found on chromosome 14 in humans: 14q32.33. [5] It consists of 1832 bp and 160 amino acids post translation. [6] [7] There is a total number of 6 exons. [5] C14orf180 is also known as NRAC, C14orf77, and Chromosome 14 Open Reading Frame 180. [5]

Contents

Isoforms

C14orf180 has two known isoforms. [5]

TranscriptAccession NumberLength
Isoform X1XP_005267694177aa
Isoform X2XP_375108160aa

Protein

General properties

C14orf180 protein consists of 160 amino acids. [7] C14orf180 has a predicted molecular weight of 18.1 kD. [8] It also has a predicted unmodified isoelectric point of 11 pI. [8]

Secondary Sequence

The predicted secondary structure was determined by a cross- program analysis. The results showed three alpha-helices and two-beta sheets. Which, was also predicted in some mammals. [9]

Regulation

Gene level regulation

Overall, C14orf180 is moderately expressed in adipose tissue, hear tissue, and skeletal muscle. [10] Slight expression is seen in a wide range of tissues as well. [10] In fetal development expression is highest in the heart tissue through 11-20 weeks, with a peak at 18 weeks. [5]

Homology

Paralogs

There are no known paralogs of the C14orf180 gene.

Orthologs

The C14orf180 gene is found in jawed vertebrates, and is highly conserved in mammals. [11] Some examples are listed below. [11]

Genius & speciesCommon NameAccession NumberLengthSequence IdentitySequence SimilarityDate of Divergence
Homo sapiensHumanAAH41103160100%100%0 MYA
Pan paniscusBonoboXP_003807050.116098.80%98.80%6.7 MYA
Mus MusculusHouse MouseNP_796013.116548.20%57.60%90 MYA
Bos taurusCattleNP_001192317.115961.20%71.20%96 MYA
Dormaius novaehollandiaeEmuXP_02596831113625.40%37.90%312 MYA

Function

The C14orf180 is predicted to be involved in low- density lipoprotein particle protein clearance; however, the function is yet to be well understood by the scientific community. [12]

Clinical significance

The clinical significance of the C14orf180 gene is yet to be well understood by the scientific community. However, the expression of C14orf180 in skeletal muscle was studied in young males or females compared to old male or females and no significant change was found. [13] C14orf180 was studied in children with obesity, no change expression was found compared to children without obesity. [14]

Related Research Articles

TSR3 protein-coding gene in the species Homo sapiens

TSR3, or TSR3 Ribosome Maturation Factor, is a hypothetical human protein found on chromosome 16. Its protein is 312 amino acids long. and its cDNA has 1214 base pairs It was previously designated C16orf42.

METTL26

An Error has occurred retrieving Wikidata item for infobox METTL26, previously designated C16orf13, is a protein-coding gene for Methyltransferase Like 26, also known as JFP2. Though the function of this gene is unknown, various data have revealed that it is expressed at high levels in various cancerous tissues. Underexpression of this gene has also been linked to disease consequences in humans.

C8orf48 protein-coding gene in the species Homo sapiens

C8orf48 is a protein that in humans is encoded by the C8orf48 gene. C8orf48 is a nuclear protein specifically predicted to be located in the nuclear lamina. C8orf48 has been found to interact with proteins that are involved in the regulation of various cellular responses like gene expression, protein secretion, cell proliferation, and inflammatory responses. This protein has been linked to breast cancer and papillary thyroid carcinoma.

C11orf86 protein-coding gene in the species Homo sapiens

Chromosome 11 open reading frame 86, also known as C11orf86, is a protein-coding gene in humans. It encodes for a protein known as uncharacterized protein C11orf86, which is predicted to be a nuclear protein. The function of this protein is currently unknown.

PRR29 protein-coding gene in the species Homo sapiens

PRR29 is a protein located on human chromosome 17 that in humans is encoded by the PRR29 gene.

C10orf67 protein-coding gene in the species Homo sapiens

Chromosome 10 open reading frame 67 (C10orf67), also known as C10orf115, LINC01552, and BA215C7.4, is an un-characterized human protein-coding gene. Several studies indicate a possible link between genetic polymorphisms of this and several other genes to chronic inflammatory barrier diseases such as Crohn's Disease and sarcoidosis.

Uncharacterized protein Chromosome 16 Open Reading Frame 71 is a protein in humans, encoded by the C16orf71 gene. The gene is expressed in epithelial tissue of the respiratory system, adipose tissue, and the testes. Predicted associated biological processes of the gene include regulation of the cell cycle, cell proliferation, apoptosis, and cell differentiation in those tissue types. 1357 bp of the gene are antisense to spliced genes ZNF500 and ANKS3, indicating possibility of regulated alternate expression.

C6orf62 protein-coding gene in the species Homo sapiens

Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12), is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol.

C17orf53 protein-coding gene in the species Homo sapiens

C17orf53 is a gene in humans that encodes a protein known as C17orf53, uncharacterized protein C17orf53. It has been shown to target the nucleus, with minor localization in the cytoplasm. Based on current findings C17orf53 is predicted to perform functions of transport, however further research into the protein could provide more specific evidence regarding its function.

C15orf39

C15orf39 is a protein that in humans is encoded by the Chromosome 15 open reading frame 15 (C15orf39) gene.

Chromosome 9 open reading frame 43 protein-coding gene in the species Homo sapiens

Chromosome 9 open reading frame 43 is a protein that in humans is encoded by the C9orf43 gene. The gene is also known as MGC17358 and LOC257169. C9orf43 contains DUF 4647 and a polyglutamine repeat region although protein function is not well understood.

C9orf25 protein-coding gene in the species Homo sapiens

Chromosome 9 open reading frame 25 (C9orf25) is a domain that encodes the FAM219A gene. The terms FAM219A and C9orf25 are aliases and can be used interchangeably. The function of this gene is not yet completely understood.

C19orf44 mammalian protein found in Homo sapiens

Chromosome 19 open reading frame 44 is a protein that in humans is encoded by the C19orf44 gene. C19orf44 is an uncharacterized protein with an unknown function in humans. C19orf44 is non-limiting implying that the protein exists in other species besides human. The protein contains one domain of unknown function (DUF) that is highly conserved throughout its orthologs. This protein is most highly expressed in the testis and ovary, but also has significant expression in the thyroid and parathyroid. Other names for this protein include: LOC84167.

C4orf51 protein-coding gene in the species Homo sapiens

Chromosome 4 open reading frame 51 (C4orf51) is a protein which in humans is encoded by the C4orf51 gene.

C9orf50 protein-coding gene in the species Homo sapiens

Chromosome 9 open reading frame 50 is a protein that in humans is encoded by the C9orf50 gene. C9orf50 has one other known alias, FLJ35803. In humans the gene coding sequence is 10,051 base pairs long, transcribing an mRNA of 1,624 bases that encodes a 431 amino acid protein.

Chromosome 1 open reading frame (C1orf167) is a protein which in humans is encoded by the C1orf167 gene.The NCBI accession number is NP_001010881. The protein is 1468 amino acids in length with a molecular weight of 162.42 kDa. The mRNA sequence was found to be 4689 base pairs in length.

C20orf202


C20orf202 is a protein that in humans is encoded by the C20orf202 gene. In humans, this gene encodes for a nuclear protein that is primarily expressed in the lung and placenta.

C1orf94 protein-coding gene in the species Homo sapiens

Chromosome 1 Opening Reading Frame 94 or C1orf94 is a protein in human coded by the C1orf94 gene. The function of this protein is still poorly understood.

C12orf24 protein-coding gene in the species Homo sapiens

C12Orf24 is a gene in humans that encodes a protein known as FAM216A. This gene is primarily expressed in the testis and brain, but has constitutive expression in 25 other tissues. FAM216A is an intracellular protein that has been predicted to reside within the nucleus of cells. The exact function of C12Orf24 is unknown. FAM216A is highly expressed in Sertoli cells of the testis as well as different stage spermatids.

Fam89A protein-coding gene in the species Homo sapiens

ProteinFAM89A is a protein which in humans is encoded by the FAM89A gene. It is also known as chromosome 1 open reading frame 153 (C1orf153). Highest FAM89A gene expression is observed in the placenta and adipose tissue. Though its function is largely unknown, FAM89A is found to be differentially expressed in response to interleukin exposure, and it is implicated in immune responses pathways and various pathologies such as atherosclerosis and glioma cell expression.

References

  1. 1 2 3 ENSG00000184601 GRCh38: Ensembl release 89: ENSG00000274126, ENSG00000184601 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043122 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 5 "C14orf180 chromosome 14 open reading frame 180 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
  6. "Homo sapiens chromosome 14 open reading frame 180, mRNA (cDNA clone MGC:46445 IMAGE:5193008), complete cds". 2007-12-04.Cite journal requires |journal= (help)
  7. 1 2 "Chromosome 14 open reading frame 180 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
  8. 1 2 "ExPASy - Compute pI/Mw tool". web.expasy.org. Retrieved 2020-05-08.
  9. "Bioinformatics Tools for Sequence Translation < EMBL-EBI". www.ebi.ac.uk. Retrieved 2020-05-08.
  10. 1 2 "GDS3113 / 118810". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
  11. 1 2 "C14orf180 orthologs". NCBI. Retrieved 2020-05-08.
  12. "ARCHS4". amp.pharm.mssm.edu. Retrieved 2020-05-08.
  13. "GDS5216 / 1558420_at". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
  14. "GDS3688 / 1558420_at". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.