C14orf180

Last updated
C14orf180
Identifiers
Aliases C14orf180 , C14orf77, NRAC, chromosome 14 open reading frame 180
External IDs MGI: 2443020; HomoloGene: 52221; GeneCards: C14orf180; OMA:C14orf180 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

400258

319942

Ensembl

ENSG00000274126
ENSG00000184601

ENSMUSG00000043122

UniProt

Q8N912

Q8BNX7

RefSeq (mRNA)

NM_001008404
NM_001286399
NM_001286400

NM_177039

RefSeq (protein)

NP_001008404
NP_001273328
NP_001273329

NP_796013

Location (UCSC) Chr 14: 104.58 – 104.59 Mb Chr 12: 112.46 – 112.47 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C14orf180 is found on chromosome 14 in humans: 14q32.33. [5] It consists of 1832 bp and 160 amino acids post translation. [6] [7] There is a total number of 6 exons. [5] C14orf180 is also known as NRAC, C14orf77, and Chromosome 14 Open Reading Frame 180. [5]

Contents

Isoforms

C14orf180 has two known isoforms. [5]

TranscriptAccession NumberLength
Isoform X1XP_005267694177aa
Isoform X2XP_375108160aa

Protein

General properties

C14orf180 protein consists of 160 amino acids. [7] C14orf180 has a predicted molecular weight of 18.1 kD. [8] It also has a predicted unmodified isoelectric point of 11 pI. [8]

Secondary Sequence

The predicted secondary structure was determined by a cross- program analysis. The results showed three alpha-helices and two-beta sheets. Which, was also predicted in some mammals. [9]

Regulation

Gene level regulation

Overall, C14orf180 is moderately expressed in adipose tissue, hear tissue, and skeletal muscle. [10] Slight expression is seen in a wide range of tissues as well. [10] In fetal development expression is highest in the heart tissue through 11-20 weeks, with a peak at 18 weeks. [5]

Homology

Paralogs

There are no known paralogs of the C14orf180 gene.

Orthologs

The C14orf180 gene is found in jawed vertebrates, and is highly conserved in mammals. [11] Some examples are listed below. [11]

Genius & speciesCommon NameAccession NumberLengthSequence IdentitySequence SimilarityDate of Divergence
Homo sapiensHumanAAH41103160100%100%0 MYA
Pan paniscusBonoboXP_003807050.116098.80%98.80%6.7 MYA
Mus MusculusHouse MouseNP_796013.116548.20%57.60%90 MYA
Bos taurusCattleNP_001192317.115961.20%71.20%96 MYA
Dormaius novaehollandiaeEmuXP_02596831113625.40%37.90%312 MYA

Function

The C14orf180 is predicted to be involved in low- density lipoprotein particle protein clearance; however, the function is yet to be well understood by the scientific community. [12]

Clinical significance

The clinical significance of the C14orf180 gene is yet to be well understood by the scientific community. However, the expression of C14orf180 in skeletal muscle was studied in young males or females compared to old male or females and no significant change was found. [13] C14orf180 was studied in children with obesity, no change expression was found compared to children without obesity. [14]

References

  1. 1 2 3 ENSG00000184601 GRCh38: Ensembl release 89: ENSG00000274126, ENSG00000184601 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043122 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 5 "C14orf180 chromosome 14 open reading frame 180 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
  6. ↑ "Homo sapiens chromosome 14 open reading frame 180, mRNA (cDNA clone MGC:46445 IMAGE:5193008), complete cds". 2007-12-04.{{cite journal}}: Cite journal requires |journal= (help)
  7. 1 2 "Chromosome 14 open reading frame 180 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
  8. 1 2 "ExPASy - Compute pI/Mw tool". web.expasy.org. Retrieved 2020-05-08.
  9. ↑ "Bioinformatics Tools for Sequence Translation < EMBL-EBI". www.ebi.ac.uk. Retrieved 2020-05-08.
  10. 1 2 "GDS3113 / 118810". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
  11. 1 2 "C14orf180 orthologs". NCBI. Retrieved 2020-05-08.
  12. ↑ "ARCHS4". amp.pharm.mssm.edu. Retrieved 2020-05-08.
  13. ↑ "GDS5216 / 1558420_at". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
  14. ↑ "GDS3688 / 1558420_at". www.ncbi.nlm.nih.gov. Retrieved 2020-05-08.
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