C1orf109

Last updated
C1orf109
Identifiers
Aliases C1orf109
External IDs OMIM: 614799 MGI: 3041172 HomoloGene: 23053 GeneCards: C1orf109
Orthologs
SpeciesHumanMouse
Entrez

54955

194268

Ensembl

ENSG00000116922

ENSMUSG00000044730

UniProt

Q9NX04

Q499E6

RefSeq (mRNA)

NM_001303030
NM_001303031
NM_017850

NM_177573
NM_001355603
NM_001355605

RefSeq (protein)

NP_808241
NP_001342532
NP_001342534

Location (UCSC)n/a Chr 4: 124.83 – 124.84 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Chromosome 1 open reading frame 109 is a protein in humans that is encoded by the C1orf109 gene. [4]

Clinical significance

This gene may play a role in cancer cell proliferation. [5]

Related Research Articles

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E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene.

<span class="mw-page-title-main">JKAMP</span> Protein-coding gene in the species Homo sapiens

JNK1-associated membrane protein is a protein that in humans is encoded by the JKAMP gene.

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Uncharacterized protein C9orf78 is a protein that in humans is encoded by the C9orf78 gene.

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<span class="mw-page-title-main">CHAMP1</span> Protein-coding gene in the species Homo sapiens

Chromosome alignment-maintaining phosphoprotein 1 (CHAMP1) also known as zinc finger protein 828 (ZNF828) is a protein that in humans is encoded by the CHAMP1 gene.

<span class="mw-page-title-main">PRICKLE4</span> Protein-coding gene in the species Homo sapiens

Prickle-like protein 4 is a protein that in humans is encoded by the PRICKLE4 gene.

<span class="mw-page-title-main">RNF220</span> Protein-coding gene in the species Homo sapiens

RING finger protein 220 is a protein that in humans is encoded by the RNF220 gene.

<span class="mw-page-title-main">C12orf43</span> Protein-coding gene in humans

Uncharacterized protein C12orf43 is a protein that in humans is encoded by the C12orf43 gene.

<span class="mw-page-title-main">CXorf40A</span> Protein-coding gene in humans

Protein CXorf40A is a protein that in humans is encoded by the CXorf40A gene.

<span class="mw-page-title-main">PPP1R17</span> Protein-coding gene in the species Homo sapiens

Protein phosphatase 1 regulatory subunit 17 is a protein that in humans is encoded by the PPP1R17 gene.

<span class="mw-page-title-main">FRA10AC1</span> Protein-coding gene in the species Homo sapiens

FRA10AC1 is a protein that in humans is encoded by the FRA10AC1 gene.

<span class="mw-page-title-main">C9orf64</span> Protein-coding gene in the species Homo sapiens

C9orf64 is a gene located on chromosome 9, that in humans encodes the protein queuosine salvage protein. The function and biological process of the queuosine salvage protein is a queuosine-nucleotide N-glycosylase/hydrolase (QNG1) that releases queuine from Q-5'-monophosphate, and this activity is required for the salvage of queuine from exogenous Queuosine by S. pombe and HeLa cells. Some evidence from orthologs indicates it may be involved in tRNA processing and recycling. The most common mRNA contains 4 coding exons, and it has 2 additional alternatively spliced exons. C9orf64 has been found in 5 different splice variants.

<span class="mw-page-title-main">CPLANE1</span> Protein-coding gene in the species Homo sapiens

Ciliogenesis And Planar Polarity Effector 1 is a protein that in humans is encoded by the CPLANE1 gene.

<span class="mw-page-title-main">C9orf16</span> Protein-coding gene in the species Homo sapiens

Chromosome 9 open reading frame 16 is a protein in humans that is encoded by the C9orf16 gene.

<span class="mw-page-title-main">C9orf152</span> Protein-coding gene in the species Homo sapiens

Chromosome 9 open reading frame 152 is a protein that in humans is encoded by the C9orf152 gene. The exact function of the protein is not completely understood.

<span class="mw-page-title-main">GMCL1</span> Protein-coding gene in the species Homo sapiens

Germ cell-less, spermatogenesis associated 1 is a protein that in humans is encoded by the GMCL1 gene.

<span class="mw-page-title-main">C15orf48</span> Protein-coding gene in the species Homo sapiens

Chromosome 15 open reading frame 48 is a protein that in humans is encoded by the C15orf48 gene.

<span class="mw-page-title-main">C11orf53</span> Protein-coding gene in the species Homo sapiens

Chromosome 11 open reading frame 53 is a protein that in humans is encoded by the C11orf53 gene. Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer. Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors. C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment. CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2 inhibitor Venetoclax, further supporting a role in cancer predisposition.

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044730 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Entrez Gene: Chromosome 1 open reading frame 109" . Retrieved 2012-10-30.
  5. ↑ Liu SS, Zheng HX, Jiang HD, He J, Yu Y, Qu YP, Yue L, Zhang Y, Li Y (2012). "Identification and characterization of a novel gene, c1orf109, encoding a CK2 substrate that is involved in cancer cell proliferation". J. Biomed. Sci. 19 (1): 49. doi: 10.1186/1423-0127-19-49 . PMC   3546425 . PMID   22548824.


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