CALCOCO2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CALCOCO2 , NDP52, calcium binding and coiled-coil domain 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604587; HomoloGene: 31339; GeneCards: CALCOCO2; OMA:CALCOCO2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene. [3] [4]
The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by HSV-1 infection and may have a role in viral life cycles. [4]
CALCOCO2 is an autophagy receptor, and loss of CALCOCO2 in human beta cells has been linked to autophagy-mediated altered insulin granule homeostasis. Thus, mutations in CALCOCO2 have been linked to type 2 diabetes risk. [5]
C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.
Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.
LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.
TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.
LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.
Calcium-binding and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the CALCOCO1 gene.
Zinc finger Ran-binding domain-containing protein 2 is a protein that in humans is encoded by the ZRANB2 gene.
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) also known as "acidic protein rich in leucines" (APRIL) is a protein that in humans is encoded by the ANP32B gene.
Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. This protein is characterized as a subunit of the autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation. This complex localizes to the membrane and is released just before or after autophagosome completion.
Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.
RNA-binding motif protein 7 is a protein that in humans is encoded by the RBM7 gene.
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ACAP2 gene.
Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene.
Ankyrin repeat and zinc finger domain-containing protein 1 is a protein that in humans is encoded by the ANKZF1 gene.
WASH complex subunit 3, formerly known as coiled-coil domain-containing protein 53 (CCDC53), is a protein that in humans is encoded by the WASHC3 gene.
Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.
Coiled-coil domain-containing protein 70 is a protein that in humans is encoded by the CCDC70 gene.
Dystrobrevin beta is a protein which in humans is encoded by the DTNB gene.
Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene.