CANT1

CANT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S18, 1S1D, 2H2N, 2H2U
Identifiers
Aliases	CANT1 , DBQD, SCAN-1, SCAN1, SHAPY, DBQD1, calcium activated nucleotidase 1, EDM7
External IDs	OMIM: 613165; MGI: 1923275; HomoloGene: 69460; GeneCards: CANT1; OMA:CANT1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	79,009,867 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,309,912 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; mucosa of transverse colon; ; rectum; ; mucosa of sigmoid colon; ; mucosa of ileum; ; stromal cell of endometrium; ; blood; ; tibia; ; placenta; ; germinal epithelium;
	Top expressed in
	pyloric antrum; ; gastrula; ; duodenum; ; intestinal villus; ; spermatocyte; ; large intestine; ; colon; ; epithelium of small intestine; ; crypt of lieberkuhn of small intestine; ; ileum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	uridine-diphosphatase activity ; hydrolase activity ; signal transducer activity ; nucleoside-diphosphatase activity ; metal ion binding ; calcium ion binding ; protein homodimerization activity ; adenosine-diphosphatase activity ; guanosine-diphosphatase activity ; pyrophosphatase activity ;
Cellular component	integral component of membrane ; Golgi cisterna membrane ; Golgi apparatus ; extracellular exosome ; endoplasmic reticulum membrane ; endoplasmic reticulum ; extracellular region ; plasma membrane ; membrane ; specific granule lumen ; tertiary granule lumen ; ficolin-1-rich granule lumen ;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling ; proteoglycan biosynthetic process ; signal transduction ; neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	124583
	76025
	ENSG00000171302
	ENSMUSG00000025575
	Q8WVQ1
	Q8VCF1
	NM_001159772 ; NM_001159773 ; NM_138793
	NM_001025617 ; NM_001025618 ; NM_001267591 ; NM_001267592 ; NM_029502 Contents References ; External links ; Further reading ;
	NP_001153244 ; NP_001153245 ; NP_620148
	NP_001020788 ; NP_001020789 ; NP_001254520 ; NP_001254521 ; NP_083778
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 02, 2024

CANT1 is a gene that encodes soluble calcium-activated nucleotidase 1, an enzyme, in humans.^[5]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171302 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025575 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Failer BU, Braun N, Zimmermann H (Sep 2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase". J Biol Chem. 277 (40): 36978–86. doi: 10.1074/jbc.M201656200 . PMID 12167635.
↑ "Entrez Gene: CANT1 calcium activated nucleotidase 1".

External links

Human CANT1 genome location and CANT1 gene details page in the UCSC Genome Browser .

Smith TM, Hicks-Berger CA, Kim S, Kirley TL (2002). "Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases". Arch. Biochem. Biophys. 406 (1): 105–15. doi:10.1016/S0003-9861(02)00420-4. PMID 12234496.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Murphy DM, Ivanenkov VV, Kirley TL (2003). "Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase". Biochemistry. 42 (8): 2412–21. doi:10.1021/bi026763b. PMID 12600208.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi: 10.1038/sj.onc.1206406 . PMID 12761501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Dai J, Liu J, Deng Y, et al. (2004). "Structure and protein design of a human platelet function inhibitor". Cell. 116 (5): 649–59. doi: 10.1016/S0092-8674(04)00172-2 . PMID 15006348. S2CID 15305441.
Yang M, Kirley TL (2004). "Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change". Biochemistry. 43 (28): 9185–94. doi:10.1021/bi049565o. PMID 15248776.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171302 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025575 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12167635-5] Failer BU, Braun N, Zimmermann H (Sep 2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase". J Biol Chem. 277 (40): 36978–86. doi: 10.1074/jbc.M201656200 . PMID 12167635.

[entrez-6] "Entrez Gene: CANT1 calcium activated nucleotidase 1".

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CANT1

Contents

Related Research Articles

References

External links

Further reading