caprin family member 2, also known as CAPRIN2, is a human gene. [5]
The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [5]
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology | Normal |
| Peripheral blood lymphocytes | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Eye Histopathology | Normal |
| Citrobacter infection | Normal [6] |
| All tests and analysis from [7] [8] |
Model organisms have been used in the study of CAPRIN2 function. A conditional knockout mouse line, called Caprin2tm1a(EUCOMM)Wtsi [9] [10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute. [11] [12] [13]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. [7] [14] Twenty two tests were carried out on mutant mice, however no significant abnormalities were observed. [7]
Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.
Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.
Cytochrome b561 is a protein that in humans is encoded by the CYB561 gene.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, also known as DDX27, is a human gene.
TBC1 domain family member 10A is a protein that in humans is encoded by the TBC1D10A gene.
Putative Polycomb group protein ASXL1 is a protein that in humans is encoded by the ASXL1 gene.
Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene. Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2.
N-terminal EF-hand calcium-binding protein 2 is a protein that in humans is encoded by the NECAB2 gene.
SLC35F6 is a protein that in humans is encoded by the SLC35F6 gene. The orthologue in mice is 4930471M23Rik.
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene. The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene.
WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.
SET and MYND domain-containing protein 4 is a protein that in humans is encoded by the SMYD4 gene.
Ninein-like protein is a protein that in humans is encoded by the NINL gene. It is part of the centrosome.
Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.
DCC-interacting protein 13-beta is a protein that in humans is encoded by the APPL2 gene.
Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene. This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.
Ubiquinone biosynthesis protein COQ9, mitochondrial, also known as coenzyme Q9 homolog (COQ9), is a protein that in humans is encoded by the COQ9 gene.
The family with sequence similarity 73, member B, also known as FAM73B, is a human gene.
