CELA3A

Last updated
CELA3A
Identifiers
Aliases CELA3A , ELA3, ELA3A, chymotrypsin like elastase family member 3A, chymotrypsin like elastase 3A
External IDs MGI: 3651647; HomoloGene: 129880; GeneCards: CELA3A; OMA:CELA3A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10136

242711

Ensembl

ENSG00000142789

ENSMUSG00000078520

UniProt

P09093

A2A9U8

RefSeq (mRNA)

NM_005747

NM_001126318

RefSeq (protein)

NP_005738

NP_001119790

Location (UCSC) Chr 1: 22 – 22.01 Mb Chr 4: 137.13 – 137.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene. [5] [6] [7]

Contents

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [7]

Related Research Articles

<span class="mw-page-title-main">Neutrophil elastase</span> Protein-coding gene in the species Homo sapiens

Neutrophil elastase is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Neutrophil elastase is secreted by neutrophils during inflammation, and destroys bacteria and host tissue. It also localizes to neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases.

<span class="mw-page-title-main">Kallikrein-5</span> Protein-coding gene in the species Homo sapiens

Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

<span class="mw-page-title-main">CSN2</span> Protein-coding gene in humans

Beta-casein is a protein that in humans is encoded by the CSN2 gene. It is in the class of phosphoproteins and generally occurs in mammalian milk.

<span class="mw-page-title-main">SERPINB1</span> Protein-coding gene in the species Homo sapiens

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins founded by ovalbumin.

<span class="mw-page-title-main">LUC7L3</span> Protein-coding gene in the species Homo sapiens

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.

<span class="mw-page-title-main">CLK3 (gene)</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.

<span class="mw-page-title-main">CELA3B</span> Protein-coding gene in the species Homo sapiens

Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in humans is encoded by the CELA3B gene.

<span class="mw-page-title-main">CELA2A</span> Protein-coding gene in the species Homo sapiens

Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene.

<span class="mw-page-title-main">KAZALD1</span> Protein-coding gene in the species Homo sapiens

Kazal-type serine protease inhibitor domain-containing protein 1 is an enzyme that in humans is encoded by the KAZALD1 gene.

<span class="mw-page-title-main">CCNL2</span> Protein-coding gene in the species Homo sapiens

Cyclin-L2 is a protein that in humans is encoded by the CCNL2 gene. The protein encoded by this gene belongs to cyclin family.

<span class="mw-page-title-main">CTRL (gene)</span> Protein-coding gene in the species Homo sapiens

Chymotrypsin-like protease CTRL-1 is an enzyme that in humans is encoded by the CTRL gene.

<span class="mw-page-title-main">RWDD2B</span> Protein-coding gene in the species Homo sapiens

RWD domain-containing protein 2B is a protein that in humans is encoded by the RWDD2B gene.

<span class="mw-page-title-main">PDCD7</span> Protein-coding gene in the species Homo sapiens

Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD7 gene.

<span class="mw-page-title-main">ADAM18</span> Protein-coding gene in the species Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.

<span class="mw-page-title-main">LRRC17</span> Protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 17 is a protein that in humans is encoded by the LRRC17 gene.

<span class="mw-page-title-main">EIF1B</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1b is a protein that in humans is encoded by the EIF1B gene.

<span class="mw-page-title-main">CCNI (gene)</span> Gene of the species Homo sapiens

Cyclin-I is a protein that in humans is encoded by the CCNI gene.

<span class="mw-page-title-main">CELA1</span> Enzyme-encoding gene in humans

Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B.

<span class="mw-page-title-main">CELA2B</span> Protein-coding gene in the species Homo sapiens

Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene.

<span class="mw-page-title-main">Chymotrypsin-C</span> Protein-coding gene in the species Homo sapiens

Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000142789 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078520 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Tani T, Ohsumi J, Mita K, Takiguchi Y (Feb 1988). "Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning". J Biol Chem. 263 (3): 1231–9. doi: 10.1016/S0021-9258(19)57291-X . PMID   2826474.
  6. ↑ Shirasu Y, Takemura K, Yoshida H, Sato Y, Iijima H, Shimada Y, Mikayama T, Ozawa T, Ikeda N, Ishida A, et al. (Dec 1988). "Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes". J Biochem. 104 (2): 259–64. doi:10.1093/oxfordjournals.jbchem.a122454. PMID   2460440.
  7. 1 2 "Entrez Gene: ELA3A elastase 3A, pancreatic".

Further reading

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