CELA3A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CELA3A , ELA3, ELA3A, chymotrypsin like elastase family member 3A, chymotrypsin like elastase 3A | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 3651647 HomoloGene: 129880 GeneCards: CELA3A | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene. [5] [6] [7]
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [7]
Neutrophil elastase is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Neutrophil elastase is secreted by neutrophils during inflammation, and destroys bacteria and host tissue. It also localizes to neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases.
Dipeptidyl-peptidase 3 is an enzyme that in humans is encoded by the DPP3 gene.
Beta-casein is a protein that in humans is encoded by the CSN2 gene. It is in the class of phosphoproteins and generally occurs in mammalian milk.
Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins founded by ovalbumin.
LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.
Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.
Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in humans is encoded by the CELA3B gene.
Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene.
Kazal-type serine protease inhibitor domain-containing protein 1 is an enzyme that in humans is encoded by the KAZALD1 gene.
Cyclin-L2 is a protein that in humans is encoded by the CCNL2 gene. The protein encoded by this gene belongs to cyclin family.
Chymotrypsin-like protease CTRL-1 is an enzyme that in humans is encoded by the CTRL gene.
RWD domain-containing protein 2B is a protein that in humans is encoded by the RWDD2B gene.
Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD7 gene.
Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.
Leucine-rich repeat-containing protein 17 is a protein that in humans is encoded by the LRRC17 gene.
Eukaryotic translation initiation factor 1b is a protein that in humans is encoded by the EIF1B gene.
Cyclin-I is a protein that in humans is encoded by the CCNI gene.
Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B.
Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene.
Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene.
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: CS1 maint: DOI inactive as of January 2024 (link)