CENTG2

AGAP1
Identifiers
Aliases	AGAP1 , AGAP-1, CENTG2, GGAP1, cnt-g2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
External IDs	OMIM: 608651 MGI: 2653690 HomoloGene: 56689 GeneCards: AGAP1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	236,131,800 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	89,825,339 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; superior vestibular nucleus; ; sural nerve; ; inferior ganglion of vagus nerve; ; corpus callosum; ; pons; ; parietal lobe; ; postcentral gyrus; ; middle frontal gyrus; ; ventral tegmental area;
	Top expressed in
	inferior colliculus; ; entorhinal cortex; ; ventromedial nucleus; ; arcuate nucleus; ; medulla oblongata; ; supraoptic nucleus; ; paraventricular nucleus of hypothalamus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; globus pallidus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; phospholipid binding ; metal ion binding ; GTPase activator activity ; GTPase activity ;
Cellular component	cytoplasm ; nucleus ;
Biological process	protein transport ; positive regulation of GTPase activity ;
	Sources:Amigo / QuickGO
Orthologs
	116987
	347722
	ENSG00000157985
	ENSMUSG00000055013
	Q9UPQ3
	Q8BXK8
	NM_001037131 ; NM_001244888 ; NM_014914
	NM_001037136 ; NM_178119
	NP_001032208 ; NP_001231817 ; NP_055729
	NP_001032213 ; NP_835220
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an enzyme that in humans is encoded by the AGAP1 gene.^[5]

Function

CENTG2 belongs to an ADP-ribosylation factor GTPase-activating (ARF-GAP) protein family involved in membrane traffic and actin cytoskeleton dynamics (Nie et al., 2002).[supplied by OMIM]^[5]

HACNS1

HACNS1 is located in an intron of the gene CENTG2 (also known as Human Accelerated Region 2). HACNS1 is hypothesized to be a gene enhancer "that may have contributed to the evolution of the uniquely opposable human thumb, and possibly also modifications in the ankle or foot that allow humans to walk on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human genome, HACNS1 has undergone the most change during the evolution of humans following the split with the ancestors of chimpanzees.^[6]

Related Research Articles

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling.

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene.

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.

ADP-ribosylation factor GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARFGAP1 gene. Two transcript variants encoding different isoforms have been found for this gene.

AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene.

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ASAP1 gene.

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000157985 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055013 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CENTG2 centaurin, gamma 2".
↑ HACNS1: Gene enhancer in evolution of human opposable thumb

External links

Human AGAP1 genome location and AGAP1 gene details page in the UCSC Genome Browser .

Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID 10470851.
Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA (Dec 2002). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". The Journal of Biological Chemistry. 277 (50): 48965–75. doi: 10.1074/jbc.M202969200 . PMID 12388557.
Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M (Apr 2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Molecular and Cellular Biology. 23 (7): 2476–88. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724 . PMID 12640130.
Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA (Sep 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Developmental Cell. 5 (3): 513–21. doi: 10.1016/S1534-5807(03)00234-X . PMID 12967569.
Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S (Nov 2004). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". The Journal of Biological Chemistry. 279 (47): 49346–54. doi: 10.1074/jbc.M410565200 . PMID 15381706.
Wassink TH, Piven J, Vieland VJ, Jenkins L, Frantz R, Bartlett CW, Goedken R, Childress D, Spence MA, Smith M, Sheffield VC (Jul 2005). "Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene". American Journal of Medical Genetics Part B. 136B (1): 36–44. doi:10.1002/ajmg.b.30180. PMID 15892143. S2CID 3858998.
Nie Z, Fei J, Premont RT, Randazzo PA (Aug 2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3". Journal of Cell Science. 118 (Pt 15): 3555–66. doi: 10.1242/jcs.02486 . PMID 16079295.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000157985 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055013 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CENTG2 centaurin, gamma 2".

[6] HACNS1: Gene enhancer in evolution of human opposable thumb

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