CHD5

CHD5
Identifiers
Aliases	CHD5 , CHD-5, chromodomain helicase DNA binding protein 5, PMNDS
External IDs	OMIM: 610771 MGI: 3036258 HomoloGene: 56712 GeneCards: CHD5
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.31 Start 6,101,787 bp [1] End 6,180,321 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 E2 Start 152,423,108 bp [2] End 152,474,651 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm cingulate gyrus Brodmann area 10 Brodmann area 9 pituitary gland Brodmann area 46 anterior pituitary superior frontal gyrus frontal pole postcentral gyrus Top expressed in subiculum dorsal tegmental nucleus cingulate gyrus visual cortex habenula lateral hypothalamus medial vestibular nucleus paraventricular nucleus of hypothalamus primary motor cortex dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding helicase activity metal ion binding H3K27me3 modified histone binding hydrolase activity ATP binding Cellular component NuRD complex membrane heterochromatin nucleus nucleoplasm cytosol nuclear speck Biological process cell differentiation regulation of transcription, DNA-templated histone H3-K27 trimethylation positive regulation of signal transduction by p53 class mediator transcription, DNA-templated nervous system development spermatogenesis histone H4 acetylation cerebral cortex neuron differentiation negative regulation of cell population proliferation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26038 269610 Ensembl ENSG00000116254 ENSMUSG00000005045 UniProt Q8TDI0 A2A8L1 RefSeq (mRNA) NM_015557 NM_001081376 NM_029216 NM_001369243 RefSeq (protein) NP_056372 NP_001074845 NP_083492 NP_001356172 Location (UCSC) Chr 1: 6.1 – 6.18 Mb Chr 4: 152.42 – 152.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene. ^{[5] [6] [7]} It is a part of the CHD subfamily of ATP-dependent chromatin remodeling complexes.

References

1. GRCh38: Ensembl release 89: ENSG00000116254 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005045 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID   11889561. S2CID   1694959.
6. Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi: 10.1038/sj.onc.1206211 . PMID   12592387.
7. "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

External links

• Human CHD5 genome location and CHD5 gene details page in the UCSC Genome Browser .

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID   9455484.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Bagchi A, Papazoglu C, Wu Y, et al. (2007). "CHD5 is a tumor suppressor at human 1p36". Cell. 128 (3): 459–75. doi: 10.1016/j.cell.2006.11.052 . PMID   17289567. S2CID   13437928.