CHST1

CHST1
Identifiers
Aliases	CHST1 , C6ST, GST-1, KS6ST, KSGal6ST, KSST, carbohydrate sulfotransferase 1
External IDs	OMIM: 603797 MGI: 1924219 HomoloGene: 2711 GeneCards: CHST1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	45,665,622 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	92,445,595 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; middle frontal gyrus; ; parietal lobe; ; amygdala; ; postcentral gyrus; ; orbitofrontal cortex; ; dorsolateral prefrontal cortex; ; caudate nucleus; ; putamen;
	Top expressed in
	lacrimal gland; ; molar; ; habenula; ; olfactory tubercle; ; subiculum; ; temporal lobe; ; prefrontal cortex; ; nucleus accumbens; ; primary motor cortex; ; piriform cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; sulfotransferase activity ; N-acetylglucosamine 6-O-sulfotransferase activity ; keratan sulfotransferase activity ;
Cellular component	Golgi membrane ; Golgi apparatus ; membrane ; integral component of membrane ; trans-Golgi network ;
Biological process	sulfur compound metabolic process ; galactose metabolic process ; inflammatory response ; keratan sulfate biosynthetic process ; polysaccharide metabolic process ; keratan sulfate metabolic process ; carbohydrate metabolic process ; N-acetylglucosamine metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	8534
	76969
	ENSG00000175264
	ENSMUSG00000027221
	O43916
	Q9EQC0
	NM_003654
	NM_023850 ; NM_001356552 ; NM_001356553
	NP_003645
	NP_076339 ; NP_001343481 ; NP_001343482
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 09, 2023

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.^[5]^[6]^[7]

Related Research Articles

Glycosaminoglycans (GAGs) or mucopolysaccharides are long, linear polysaccharides consisting of repeating disaccharide units. The repeating two-sugar unit consists of a uronic sugar and an amino sugar, except in the case of the sulfated glycosaminoglycan keratan, where, in place of the uronic sugar there is a galactose unit. GAGs are found in vertebrates, invertebrates and bacteria. Because GAGs are highly polar molecules and attract water; the body uses them as lubricants or shock absorbers.

Selectin P ligand, also known as SELPLG or CD162, is a human gene.

<span class="mw-page-title-main">P-selectin</span> Type-1 transmembrane protein

P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.

Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene.

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.

Carbohydrate sulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene.

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

<span class="mw-page-title-main">Carbohydrate sulfotransferase</span> Class of enzymes which transfer an –SO3 group to glycoproteins and lipids

In biochemistry, carbohydrate sulfotransferases are enzymes within the class of sulfotransferases which catalyze the transfer of the sulfate functional group to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase. This enzyme catalyses the following chemical reaction

Heparan sulfate 6-O-sulfotransferase 2 is a protein that in humans is encoded by the HS6ST2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175264 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027221 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fukuta M, Inazawa J, Torii T, Tsuzuki K, Shimada E, Habuchi O (Jan 1998). "Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase". J Biol Chem. 272 (51): 32321–8. doi: 10.1074/jbc.272.51.32321 . PMID 9405439.
↑ Mazany KD, Peng T, Watson CE, Tabas I, Williams KJ (Aug 1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization". Biochim Biophys Acta. 1407 (1): 92–7. doi: 10.1016/s0925-4439(98)00028-3 . PMID 9639683.
↑ "Entrez Gene: CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1".

External links

Human CHST1 genome location and CHST1 gene details page in the UCSC Genome Browser .

Williams KJ (1997). "Atherosclerosis: cell biology and lipoproteins". Curr. Opin. Lipidol. 7 (6): U202–8. doi:10.1097/00041433-199612000-00016. PMID 9117134.
Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329 . PMID 1433500.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448 . PMID 8419650.
Li X, Tedder TF (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. 55 (3): 345–7. doi:10.1006/geno.1998.5653. PMID 10049591.
Bistrup A, Bhakta S, Lee JK, et al. (1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin". J. Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194 . PMID 10330415.
Tu L, Murphy PG, Li X, Tedder TF (1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1". J. Immunol. 163 (9): 5070–8. PMID 10528213.
Torii T, Fukuta M, Habuchi O (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase". Glycobiology. 10 (2): 203–11. doi: 10.1093/glycob/10.2.203 . PMID 10642612.
Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4): 565–74. doi: 10.1189/jlb.69.4.565 . PMID 11310842. S2CID 8888883.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Yamada T, Ohtake S, Sato M, Habuchi O (2005). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". Biochem. J. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMC 1134142 . PMID 15324304.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Liu J, Chau CH, Liu H, et al. (2006). "Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth". J. Cell Sci. 119 (Pt 5): 933–42. doi: 10.1242/jcs.02796 . hdl: 10722/44575 . PMID 16495484.
Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". J. Biol. Chem. 282 (41): 30085–96. doi: 10.1074/jbc.M703695200 . PMID 17690104.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000175264 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027221 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9405439-5] Fukuta M, Inazawa J, Torii T, Tsuzuki K, Shimada E, Habuchi O (Jan 1998). "Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase". J Biol Chem. 272 (51): 32321–8. doi: 10.1074/jbc.272.51.32321 . PMID 9405439.

[pmid9639683-6] Mazany KD, Peng T, Watson CE, Tabas I, Williams KJ (Aug 1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization". Biochim Biophys Acta. 1407 (1): 92–7. doi: 10.1016/s0925-4439(98)00028-3 . PMID 9639683.

[entrez-7] "Entrez Gene: CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1".

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CHST1

Contents

Related Research Articles

References

External links

Further reading