CHST10

CHST10
Identifiers
Aliases	CHST10 , HNK-1ST, HNK1ST, carbohydrate sulfotransferase 10
External IDs	OMIM: 606376 MGI: 2138283 HomoloGene: 21013 GeneCards: CHST10
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q11.2 Start 100,391,860 bp [1] End 100,417,668 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 B Start 38,902,948 bp [2] End 38,937,242 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence middle temporal gyrus frontal pole Brodmann area 10 Brodmann area 9 secondary oocyte putamen nucleus accumbens cingulate gyrus caudate nucleus Top expressed in visual cortex superior frontal gyrus cerebellar cortex medial dorsal nucleus dorsal tegmental nucleus medial vestibular nucleus habenula dorsomedial hypothalamic nucleus superior colliculus medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity HNK-1 sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process cell adhesion carbohydrate biosynthetic process carbohydrate metabolic process proteoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9486 98388 Ensembl ENSG00000115526 ENSMUSG00000026080 UniProt O43529 Q6PGK7 RefSeq (mRNA) NM_004854 NM_145142 NM_001368780 RefSeq (protein) NP_004845 NP_660124 NP_001355709 Location (UCSC) Chr 2: 100.39 – 100.42 Mb Chr 1: 38.9 – 38.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene. ^{[5] [6]}

Cell surface carbohydrates modulate a variety of cellular functions and are typically synthesized in a stepwise manner. HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), a neuronally expressed carbohydrate that contains a sulfoglucuronyl residue.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000115526 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026080 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi: 10.1074/jbc.M204907200 . PMID   12080076.
6. "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

External links

• Human CHST10 genome location and CHST10 gene details page in the UCSC Genome Browser .

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ong E, Yeh JC, Ding Y, et al. (1999). "Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis". J. Biol. Chem. 274 (36): 25608–12. doi: 10.1074/jbc.274.36.25608 . PMID   10464296.
• Ong E, Yeh JC, Ding Y, et al. (1998). "Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids". J. Biol. Chem. 273 (9): 5190–5. doi: 10.1074/jbc.273.9.5190 . PMID   9478973.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC   237448 . PMID   8419650.
• Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC   240329 . PMID   1433500.