CHST11

CHST11
Identifiers
Aliases	CHST11 , C4ST, C4ST-1, C4ST1, HSA269537, carbohydrate (chondroitin 4) sulfotransferase 11, carbohydrate sulfotransferase 11, OCBMD
External IDs	OMIM: 610128 MGI: 1927166 HomoloGene: 56808 GeneCards: CHST11
Gene location (Human)
Chr.	Chromosome 12 (human)
End	104,762,014 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	83,031,734 bp
RNA expression pattern
	Top expressed in
	tibia; ; blood; ; monocyte; ; bone marrow cells; ; amniotic fluid; ; spongy bone; ; internal globus pallidus; ; appendix; ; lymph node; ; visceral pleura;
	Top expressed in
	cumulus cell; ; molar; ; fossa; ; medial dorsal nucleus; ; condyle; ; substantia nigra; ; subiculum; ; median eminence; ; arcuate nucleus; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; sulfotransferase activity ; N-acetylgalactosamine 4-O-sulfotransferase activity ; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity ; chondroitin 4-sulfotransferase activity ;
Cellular component	Golgi apparatus ; membrane ; Golgi membrane ; integral component of membrane ;
Biological process	embryonic skeletal system morphogenesis ; chondrocyte development ; embryonic digit morphogenesis ; negative regulation of apoptotic process ; negative regulation of transforming growth factor beta receptor signaling pathway ; post-embryonic development ; respiratory gaseous exchange by respiratory system ; cartilage development ; developmental growth ; regulation of cell population proliferation ; embryonic limb morphogenesis ; polysaccharide localization ; post-anal tail morphogenesis ; embryonic viscerocranium morphogenesis ; carbohydrate biosynthetic process ; chondroitin sulfate biosynthetic process ; chondroitin sulfate metabolic process ; carbohydrate metabolic process ; proteoglycan biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	50515
	58250
	ENSG00000171310
	ENSMUSG00000034612
	Q9NPF2
	Q9JME2
	NM_018413 ; NM_001173982
	NM_021439
	NP_001167453 ; NP_060883 ; NP_060883.1
	NP_067414
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.^[5]^[6]

Clinical relevance

Mutations in this gene have been associated to susceptibility for osteoarthritis.^[7]

Related Research Articles

Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene.

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.

Carbohydrate sulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene.

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.

Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene.

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene.

<span class="mw-page-title-main">Carbohydrate sulfotransferase</span> Class of enzymes which transfer an –SO3 group to glycoproteins and lipids

In biochemistry, carbohydrate sulfotransferases are enzymes within the class of sulfotransferases which catalyze the transfer of the sulfate functional group to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase. This enzyme catalyses the following chemical reaction

Dermatan 4-sulfotransferase is an enzyme with systematic name 3'-phospho-5'-adenylyl sulfate:(dermatan)-N-acetyl-D-galactosamine 4-sulfotransferase. This enzyme catalyses the following chemical reaction

Carbohydrate sulfotransferase 13 is a protein that is encoded in humans by the CHST13 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171310 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034612 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Jun 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". The Journal of Biological Chemistry. 275 (26): 20188–96. doi: 10.1074/jbc.M002443200 . PMID 10781601.
↑ "Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11".
↑ Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, et al. (Sep 2012). "Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study". Lancet. 380 (9844): 815–23. doi:10.1016/S0140-6736(12)60681-3. PMC 3443899 . PMID 22763110.

External links

Human CHST11 genome location and CHST11 gene details page in the UCSC Genome Browser .

Yamauchi S, Mita S, Matsubara T, Fukuta M, Habuchi H, Kimata K, Habuchi O (Mar 2000). "Molecular cloning and expression of chondroitin 4-sulfotransferase". The Journal of Biological Chemistry. 275 (12): 8975–81. doi: 10.1074/jbc.275.12.8975 . PMID 10722746.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, Fukuta M, Kuroiwa A, Matsuda Y, Habuchi O (Nov 2000). "Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase". Journal of Biochemistry. 128 (5): 763–70. doi:10.1093/oxfordjournals.jbchem.a022813. PMID 11056388.
Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (Sep 2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". The Journal of Biological Chemistry. 278 (38): 36115–27. doi: 10.1074/jbc.M306044200 . PMID 12847091.
Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H, Haas OA, Chaganti RS (Sep 2004). "Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32)". Oncogene. 23 (41): 6991–6. doi: 10.1038/sj.onc.1207934 . PMID 15273723.
Yamada T, Ohtake S, Sato M, Habuchi O (Dec 2004). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". The Biochemical Journal. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMC 1134142 . PMID 15324304.
Yusa A, Kitajima K, Habuchi O (May 2005). "N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1". The Biochemical Journal. 388 (Pt 1): 115–21. doi:10.1042/BJ20041573. PMC 1186699 . PMID 15628971.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171310 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034612 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10781601-5] Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Jun 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". The Journal of Biological Chemistry. 275 (26): 20188–96. doi: 10.1074/jbc.M002443200 . PMID 10781601.

[entrez-6] "Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11".

[7] Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, et al. (Sep 2012). "Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study". Lancet. 380 (9844): 815–23. doi:10.1016/S0140-6736(12)60681-3. PMC 3443899 . PMID 22763110.

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CHST11

Contents

Clinical relevance

Related Research Articles

References

External links

Further reading