CHST5

CHST5
Identifiers
Aliases	CHST5 , I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST, carbohydrate sulfotransferase 5
External IDs	OMIM: 604817; HomoloGene: 69379; GeneCards: CHST5; OMA:CHST5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q23.1 Start 75,528,530 bp [1] End 75,536,108 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum rectum mucosa of transverse colon right uterine tube ventricular zone gonad cerebellum cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity N-acetylglucosamine 6-O-sulfotransferase activity Cellular component Golgi membrane Golgi apparatus intrinsic component of Golgi membrane membrane integral component of membrane trans-Golgi network Biological process sulfur compound metabolic process protein sulfation keratan sulfate biosynthetic process N-acetylglucosamine metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23563 n/a Ensembl ENSG00000135702 n/a UniProt Q9GZS9 n/a RefSeq (mRNA) NM_024533 NM_012126 n/a RefSeq (protein) NP_078809 n/a Location (UCSC) Chr 16: 75.53 – 75.54 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Carbohydrate sulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000135702 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Lee JK, Bhakta S, Rosen SD, Hemmerich S (Sep 1999). "Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue". Biochemical and Biophysical Research Communications. 263 (2): 543–9. doi:10.1006/bbrc.1999.1324. PMID   10491328.
4. Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (Oct 2000). "Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene". Nature Genetics. 26 (2): 237–41. doi:10.1038/79987. PMID   11017086. S2CID   25547752.
5. "Entrez Gene: CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5".

External links

• Human CHST5 genome location and CHST5 gene details page in the UCSC Genome Browser .

Further reading

• Bernstein HB, Compans RW (Dec 1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". Journal of Virology. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC   240329 . PMID   1433500.
• Shilatifard A, Merkle RK, Helland DE, Welles JL, Haseltine WA, Cummings RD (Feb 1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". Journal of Virology. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC   237448 . PMID   8419650.
• Bartes A, Bhakta S, Hemmerich S (Apr 2001). "Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)". Biochemical and Biophysical Research Communications. 282 (4): 928–33. doi:10.1006/bbrc.2001.4668. PMID   11352640.
• Seko A, Nagata K, Yonezawa S, Yamashita K (Jun 2002). "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma". Glycobiology. 12 (6): 379–88. doi: 10.1093/glycob/12.6.379 . PMID   12107080.
• Akama TO, Misra AK, Hindsgaul O, Fukuda MN (Nov 2002). "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate". The Journal of Biological Chemistry. 277 (45): 42505–13. doi: 10.1074/jbc.M207412200 . PMID   12218059.
• Lee JK, Bistrup A, van Zante A, Rosen SD (Apr 2003). "Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications". Glycobiology. 13 (4): 245–54. doi:10.1093/glycob/cwg018. PMID   12626414.
• de Graffenried CL, Bertozzi CR (Oct 2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis". The Journal of Biological Chemistry. 278 (41): 40282–95. doi: 10.1074/jbc.M304928200 . PMID   12855678.
• Kitayama K, Hayashida Y, Nishida K, Akama TO (Oct 2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". The Journal of Biological Chemistry. 282 (41): 30085–96. doi: 10.1074/jbc.M703695200 . PMID   17690104.