CLYBL (gene)

CLYBL
Identifiers
Aliases	CLYBL , CLB, citrate lyase beta like, citramalyl-CoA lyase
External IDs	OMIM: 609686; MGI: 1916884; HomoloGene: 49925; GeneCards: CLYBL; OMA:CLYBL - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q32.3 Start 99,606,669 bp [1] End 99,897,134 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 E5 Start 122,419,116 bp [2] End 122,639,646 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver human kidney muscle of thigh mucosa of transverse colon gastrocnemius muscle rectum vastus lateralis muscle left ventricle apex of heart jejunal mucosa Top expressed in interventricular septum right kidney brown adipose tissue myocardium of ventricle human kidney proximal tubule secondary oocyte intercostal muscle cardiac muscles soleus muscle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity catalytic activity malate synthase activity magnesium ion binding metal ion binding lyase activity (S)-citramalyl-CoA lyase activity Cellular component mitochondrion membrane integral component of membrane Biological process protein homotrimerization regulation of cobalamin metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 171425 69634 Ensembl ENSG00000125246 ENSMUSG00000025545 UniProt Q8N0X4 Q5JVC1 Q8R4N0 RefSeq (mRNA) NM_206808 NM_029556 RefSeq (protein) NP_996531 NP_083832 Location (UCSC) Chr 13: 99.61 – 99.9 Mb Chr 14: 122.42 – 122.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Citrate lyase beta like is a protein that in humans is encoded by the CLYBL gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000125246 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025545 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Citrate lyase beta like" . Retrieved 2018-07-02.

Further reading

• Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutat. Res. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID   20800603.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9) e12862. Bibcode:2010PLoSO...512862H. doi: 10.1371/journal.pone.0012862 . PMC   2943476 . PMID   20877624.