CMP kinase

CMPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TEV
Identifiers
Aliases	CMPK1 , CK, CMK, CMPK, UMK, UMP-CMPK, UMPK, cytidine/uridine monophosphate kinase 1
External IDs	OMIM: 191710 MGI: 1913838 HomoloGene: 32308 GeneCards: CMPK1
EC number	2.7.4.6
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p33 Start 47,333,790 bp [1] End 47,378,839 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D1 Start 114,816,533 bp [2] End 114,844,438 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa palpebral conjunctiva parotid gland duodenum rectum tibia oral cavity Achilles tendon islet of Langerhans gallbladder Top expressed in saccule otic placode left colon olfactory epithelium gastric mucosa mucous cell of stomach epithelium of stomach crypt of lieberkuhn of small intestine intestinal villus ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding uridylate kinase activity kinase activity nucleobase-containing compound kinase activity uridine kinase activity nucleoside diphosphate kinase activity ATP binding cytidylate kinase activity nucleoside monophosphate kinase activity Cellular component cytoplasm cytosol extracellular exosome nucleus nucleolus Biological process nucleobase-containing small molecule interconversion phosphorylation nucleoside diphosphate phosphorylation pyrimidine ribonucleotide biosynthetic process pyrimidine nucleotide biosynthetic process 'de novo' pyrimidine nucleobase biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound metabolic process nucleoside monophosphate phosphorylation UMP biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51727 66588 Ensembl ENSG00000162368 ENSMUSG00000028719 UniProt P30085 Q9DBP5 RefSeq (mRNA) NM_001136140 NM_016308 NM_001366135 NM_025647 RefSeq (protein) NP_001129612 NP_057392 NP_001353064 NP_079923 Location (UCSC) Chr 1: 47.33 – 47.38 Mb Chr 4: 114.82 – 114.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene. ^{[5] [6]}

Function

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis. ^{[6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000162368 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028719 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Molecular Pharmacology. 56 (3): 562–9. doi:10.1124/mol.56.3.562. PMID   10462544. S2CID   22945276.
6. EntrezGene 51727
7. Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID   11912132.

External links

• Human CMPK1 genome location and CMPK1 gene details page in the UCSC Genome Browser .

Further reading

• Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (1992). "Human liver protein map: A reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID   1286669. S2CID   23518983.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF (1993). "Human liver protein map: Update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID   8313870. S2CID   33424554.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM (2001). "Characterization of human UMP-CMP kinase enzymatic activity and 5′ untranslated region". Life Sciences. 69 (20): 2361–70. doi:10.1016/S0024-3205(01)01322-4. PMID   11681623.
• Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID   11912132.
• Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D (2003). "Reaction of human UMP-CMP kinase with natural and analog substrates". European Journal of Biochemistry. 270 (8): 1784–90. doi: 10.1046/j.1432-1033.2003.03537.x . PMID   12694191.
• Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A (2004). "Substrate-induced Conformational Changes in Human UMP/CMP Kinase". Journal of Biological Chemistry. 279 (32): 33882–9. doi: 10.1074/jbc.M401989200 . hdl: 11858/00-001M-0000-0012-EC87-4 . PMID   15163660.
• Hsu CH, Liou JY, Dutschman GE, Cheng YC (2004). "Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase is Differentially Regulated by ATP and Magnesium". Molecular Pharmacology. 67 (3): 806–14. doi:10.1124/mol.104.006098. PMID   15550676. S2CID   579635.
• Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG (2005). "Beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". Journal of Neurochemistry. 92 (1): 93–102. doi: 10.1111/j.1471-4159.2004.02840.x . PMID   15606899.
• Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D (2007). "Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives – a screening based on affinity for the UMP-CMP binding site". FEBS Journal. 274 (14): 3704–14. doi: 10.1111/j.1742-4658.2007.05902.x . PMID   17608725.
• Gagyi C, Bucurenci N, Sîrbu O, Labesse G, Ionescu M, Ofiteru A, Assairi L, Landais S, Danchin A, Bârzu O, Gilles AM (2003). "UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity". European Journal of Biochemistry. 270 (15): 3196–204. doi: 10.1046/j.1432-1033.2003.03702.x . PMID   12869195.
• Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM (2007). "Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase". The FEBS Journal. 274 (13): 3363–73. doi: 10.1111/j.1742-4658.2007.05870.x . PMID   17542990. S2CID   2394831.