Proprotein convertase 2 (PC2) also known as prohormone convertase 2 or neuroendocrine convertase 2 (NEC2) is a serine protease and proprotein convertase PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates. To generate the bioactive form of insulin, a second step involving the removal of C-terminal basic residues is required; this step is mediated by carboxypeptidases E and/or D. PC2 plays only a minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis compared to PC1. PC2 binds to the neuroendocrine protein named 7B2, and if this protein is not present, proPC2 cannot become enzymatically active. 7B2 accomplishes this by preventing the aggregation of proPC2 to inactivatable forms. The C-terminal domain of 7B2 also inhibits PC2 activity until it is cleaved into smaller inactive forms that lack carboxy-terminal basic residues. Thus, 7B2 is both an activator and an inhibitor of PC2. PC2 has been identified in a number of animals, including C. elegans.
Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.
The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.
Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.
Islet cell autoantigen 1 is a protein that in humans is encoded by the ICA1 gene.
Apolipoprotein M is a protein that in humans is encoded by the APOM gene.
Protein phosphatase 1 regulatory subunit 3A is an enzyme that in humans is encoded by the PPP1R3A gene.
Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene.
Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.
Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.
Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.
Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) also known as islet cell autoantigen-related protein (ICAAR) and phogrin is an enzyme that in humans is encoded by the PTPRN2 gene. PTPRN and PTPRN2 are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.
Actin-binding Rho-activating protein is a protein that in humans is encoded by the ABRA gene. The mouse and rat homologues are known as STARS and MS1 respectively.
Protein Dom3Z is a protein that in humans is encoded by the DOM3Z gene.
Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.
Carnosinemia is a rare autosomal recessive metabolic disorder caused by a deficiency of carnosinase, a dipeptidase.
Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.
Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.
Cytosolic non-specific dipeptidase also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene. This enzyme catalyses the following chemical reaction
Beta-Ala-His dipeptidase is an enzyme. This enzyme catalyses the following chemical reaction
