CPA5

CPA5
Identifiers
Aliases	CPA5 , carboxypeptidase A5
External IDs	OMIM: 609561; MGI: 1921899; HomoloGene: 62246; GeneCards: CPA5; OMA:CPA5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q32.2 Start 130,344,816 bp [1] End 130,368,730 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 A3.3 Start 30,611,009 bp [2] End 30,631,744 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis sperm gonad lymph node body of pancreas pituitary gland anterior pituitary spleen Top expressed in spermatid seminiferous tubule spermatocyte embryo embryo morula yolk sac genital tubercle islet of Langerhans trachea More reference expression data BioGPS n/a
Gene ontology Molecular function carboxypeptidase activity zinc ion binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metallocarboxypeptidase activity Cellular component extracellular region extracellular space Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93979 74649 Ensembl ENSG00000158525 ENSMUSG00000029788 UniProt Q8WXQ8 Q8R4H4 RefSeq (mRNA) NM_001127441 NM_001127442 NM_080385 NM_001318223 NM_144537 RefSeq (protein) NP_001120913 NP_001120914 NP_001305152 NP_525124 NP_653120 Location (UCSC) Chr 7: 130.34 – 130.37 Mb Chr 6: 30.61 – 30.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene. ^{[5] [6]}

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000158525 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029788 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem. 277 (17): 14954–64. doi: 10.1074/jbc.M112254200 . PMID   11836249.
6. "Entrez Gene: CPA5 carboxypeptidase A5".

External links

• Human CPA5 genome location and CPA5 gene details page in the UCSC Genome Browser .

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome". J. Med. Genet. 40 (4): 249–56. doi:10.1136/jmg.40.4.249. PMC   1735416 . PMID   12676894.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Mol. Psychiatry. 7 (3): 289–301. doi:10.1038/sj.mp.4001004. PMID   11920156. S2CID   13282515.
• "A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium". Hum. Mol. Genet. 7 (3): 571–8. 1998. doi: 10.1093/hmg/7.3.571 . hdl: 11858/00-001M-0000-0012-C9D8-C . PMID   9546821.