CPA5

Last updated
CPA5
Identifiers
Aliases CPA5 , carboxypeptidase A5
External IDs OMIM: 609561 MGI: 1921899 HomoloGene: 62246 GeneCards: CPA5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127441
NM_001127442
NM_080385
NM_001318223

NM_144537

RefSeq (protein)

NP_001120913
NP_001120914
NP_001305152
NP_525124

NP_653120

Location (UCSC) Chr 7: 130.34 – 130.37 Mb Chr 6: 30.61 – 30.63 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene. [5] [6]

Contents

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM] [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000158525 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029788 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem. 277 (17): 14954–64. doi: 10.1074/jbc.M112254200 . PMID   11836249.
  6. 1 2 "Entrez Gene: CPA5 carboxypeptidase A5".

Further reading