CPA5

CPA5
Identifiers
Aliases	CPA5 , carboxypeptidase A5
External IDs	OMIM: 609561; MGI: 1921899; HomoloGene: 62246; GeneCards: CPA5; OMA:CPA5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	130,368,730 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,631,744 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; sperm; ; gonad; ; lymph node; ; body of pancreas; ; pituitary gland; ; anterior pituitary; ; spleen;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; embryo; ; embryo; ; morula; ; yolk sac; ; genital tubercle; ; islet of Langerhans; ; trachea;
	More reference expression data
	n/a
Gene ontology
Molecular function	carboxypeptidase activity ; zinc ion binding ; peptidase activity ; hydrolase activity ; metallopeptidase activity ; metal ion binding ; metallocarboxypeptidase activity ;
Cellular component	extracellular region ; extracellular space ;
Biological process	proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	93979
	74649
	ENSG00000158525
	ENSMUSG00000029788
	Q8WXQ8
	Q8R4H4
	NM_001127441 ; NM_001127442 ; NM_080385 ; NM_001318223
	NM_144537
	NP_001120913 ; NP_001120914 ; NP_001305152 ; NP_525124
	NP_653120
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 16, 2024

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.^[5]^[6]

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000158525 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029788 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem. 277 (17): 14954–64. doi: 10.1074/jbc.M112254200 . PMID 11836249.
1 2 "Entrez Gene: CPA5 carboxypeptidase A5".

External links

Human CPA5 genome location and CPA5 gene details page in the UCSC Genome Browser .

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome". J. Med. Genet. 40 (4): 249–56. doi:10.1136/jmg.40.4.249. PMC 1735416 . PMID 12676894.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Mol. Psychiatry. 7 (3): 289–301. doi:10.1038/sj.mp.4001004. PMID 11920156. S2CID 13282515.
"A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium". Hum. Mol. Genet. 7 (3): 571–8. 1998. doi: 10.1093/hmg/7.3.571 . hdl: 11858/00-001M-0000-0012-C9D8-C . PMID 9546821.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000158525 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029788 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11836249-5] Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem. 277 (17): 14954–64. doi: 10.1074/jbc.M112254200 . PMID 11836249.

[entrez-6] 1 2 "Entrez Gene: CPA5 carboxypeptidase A5".

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CPA5

Contents

Related Research Articles

References

External links

Further reading