CSNK1E

CSNK1E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HNI, 4HOK
Identifiers
Aliases	CSNK1E , CKIepsilon, HCKIE, Casein kinase 1 isoform epsilon, casein kinase 1 epsilon, CKIe
External IDs	OMIM: 600863; MGI: 1351660; HomoloGene: 121695; GeneCards: CSNK1E; OMA:CSNK1E - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 38,290,691 bp [1] End 38,318,084 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 79,302,056 bp [2] End 79,339,767 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence left ovary ventricular zone right uterine tube canal of the cervix body of uterus right ovary stromal cell of endometrium anterior pituitary skin of leg Top expressed in zygote secondary oocyte ganglionic eminence lip genital tubercle ventricular zone medial ganglionic eminence Rostral migratory stream granulocyte tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding ATP binding RNA binding Cellular component cytoplasm cytosol nucleus nucleoplasm growth cone neuron projection soma Biological process phosphorylation rhythmic process Wnt signaling pathway negative regulation of protein binding protein phosphorylation G2/M transition of mitotic cell cycle peptidyl-serine phosphorylation DNA repair signal transduction endocytosis regulation of cell shape rRNA processing ciliary basal body-plasma membrane docking positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation positive regulation of proteasomal ubiquitin-dependent protein catabolic process circadian regulation of gene expression regulation of circadian rhythm positive regulation of non-canonical Wnt signaling pathway regulation of G2/M transition of mitotic cell cycle circadian behavior positive regulation of amyloid-beta formation cellular response to nerve growth factor stimulus peptidyl-threonine phosphorylation canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1454 27373 Ensembl ENSG00000213923 ENSMUSG00000022433 UniProt P49674 Q9JMK2 RefSeq (mRNA) NM_001894 NM_152221 NM_013767 NM_001289898 NM_001289899 NM_001359862 NM_001359863 RefSeq (protein) NP_001885 NP_689407 NP_001276827 NP_001276828 NP_038795 NP_001346791 NP_001346792 Location (UCSC) Chr 22: 38.29 – 38.32 Mb Chr 15: 79.3 – 79.34 Mb PubMed search [3] [4]
Wikidata
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Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene. ^{[5] [6]}

Function

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene. ^[7]

Interactions

CSNK1E has been shown to interact with PER1 ^[8] and AXIN1. ^[9]

Inhibitors

Selective

• PF-4800567

Non-selective

• PF-670462 (also inhibits CK1-δ)

See also

• Casein kinase 1 isoform epsilon
• Casein kinase 1 family

References

1. GRCh38: Ensembl release 89: ENSG00000213923 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022433 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jun 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry. 270 (25): 14875–83. doi: 10.1074/jbc.270.25.14875 . PMID   7797465.
6. Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America. 96 (22): 12548–52. doi: 10.1073/pnas.96.22.12548 . PMC   22983 . PMID   10535959.
7. "Entrez Gene: CSNK1E casein kinase 1, epsilon".
8. Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM (Jul 2000). "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Molecular and Cellular Biology. 20 (13): 4888–99. doi:10.1128/MCB.20.13.4888-4899.2000. PMC   85940 . PMID   10848614.
9. Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi: 10.1074/jbc.M111982200 . PMID   11884395.

External links

• Human CSNK1E genome location and CSNK1E gene details page in the UCSC Genome Browser .
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Casein kinase I isoform epsilon (CSNK1E)