CST8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CST8 , CRES, CTES5, cystatin 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 608683 MGI: 107161 HomoloGene: 4011 GeneCards: CST8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Cystatin-8 is a protein that in humans is encoded by the CST8 gene. [5] [6]
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of putative variants has not been determined. [6]
Cystatin-A is a protein that in humans is encoded by the CSTA gene.
Cystatin-B is a protein that in humans is encoded by the CSTB gene.
Cystatin-S is a protein that in humans is encoded by the CST4 gene.
Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein, is a protein that in humans is encoded by the MST1 gene.
Cystatin-SN is a protein that in humans is encoded by the CST1 gene.
Cystatin-SA is a protein that in humans is encoded by the CST2 gene.
Cystatin-M is a protein that in humans is encoded by the CST6 gene.
Cystatin-F is a protein that in humans is encoded by the CST7 gene.
Cystatin-D is a protein that in humans is encoded by the CST5 gene.
Outer dense fiber protein 1 is a protein that in humans is encoded by the ODF1 gene.
Early placenta insulin-like peptide is a protein that in humans is encoded by the INSL4 gene.
Cystatin-9-like is a protein that in humans is encoded by the CST9L gene.
Zinc finger X-chromosomal protein is a protein that in mammals is encoded by the ZFX gene of the X chromosome.
Cysteine-rich secretory protein 1 is a cysteine-rich secretory protein that in humans is encoded by the CRISP1 gene.
Cystatin-11 is a protein that in humans is encoded by the CST11 gene.
Fetuin-B is a protein that in humans is encoded by the FETUB gene.
Outer dense fiber protein 2, also known as cenexin, is a protein that in humans is encoded by the ODF2 gene.
Spermatogenic leucine zipper protein 1 is a protein that in humans is encoded by the SPZ1 gene.
Cystatin-like 1 is a protein that in humans is encoded by the CSTL1 gene.
Eppin is a protein that in humans is encoded by the SPINLW1 gene.