CTDSP1

Last updated
CTDSP1
Protein CTDSP1 PDB 1t9z.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CTDSP1 , NIF3, NLI-IF, NLIIF, SCP1, CTD small phosphatase 1
External IDs OMIM: 605323 MGI: 2654470 HomoloGene: 100834 GeneCards: CTDSP1
Orthologs
SpeciesHumanMouse
Entrez

58190

227292

Ensembl

ENSG00000144579

ENSMUSG00000026176

UniProt

Q9GZU7

P58466

RefSeq (mRNA)

NM_001206878
NM_001206879
NM_021198
NM_182642

NM_153088

RefSeq (protein)

NP_001193807
NP_067021
NP_872580

NP_694728

Location (UCSC) Chr 2: 218.4 – 218.41 Mb Chr 1: 74.43 – 74.44 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene. [5] [6] [7]

Interactions

CTDSP1 has been shown to interact with SNAI1. [8]

Related Research Articles

<span class="mw-page-title-main">RNA polymerase II</span> Protein complex that transcribes DNA

RNA polymerase II is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryotic cells. A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase. A wide range of transcription factors are required for it to bind to upstream gene promoters and begin transcription.

<span class="mw-page-title-main">Capping enzyme</span>

A capping enzyme (CE) is an enzyme that catalyzes the attachment of the 5' cap to messenger RNA molecules that are in the process of being synthesized in the cell nucleus during the first stages of gene expression. The addition of the cap occurs co-transcriptionally, after the growing RNA molecule contains as little as 25 nucleotides. The enzymatic reaction is catalyzed specifically by the phosphorylated carboxyl-terminal domain (CTD) of RNA polymerase II. The 5' cap is therefore specific to RNAs synthesized by this polymerase rather than those synthesized by RNA polymerase I or RNA polymerase III. Pre-mRNA undergoes a series of modifications - 5' capping, splicing and 3' polyadenylation before becoming mature mRNA that exits the nucleus to be translated into functional proteins and capping of the 5' end is the first of these modifications. Three enzymes, RNA triphosphatase, guanylyltransferase, and methyltransferase are involved in the addition of the methylated 5' cap to the mRNA.

<span class="mw-page-title-main">POLR2A</span> Protein-coding gene in the species Homo sapiens

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the POLR2A gene.

<span class="mw-page-title-main">POLR2K</span> Protein-coding gene in the species Homo sapiens

DNA-directed RNA polymerases I, II, and III subunit RPABC4 is a protein that in humans is encoded by the POLR2K gene.

<span class="mw-page-title-main">ILF3</span> Protein-coding gene in the species Homo sapiens

Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene.

<span class="mw-page-title-main">TCEA1</span> Human protein-coding gene

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.

<span class="mw-page-title-main">CTDP1</span>

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.

<span class="mw-page-title-main">SFRS7</span> Protein-coding gene in the species Homo sapiens

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.

<span class="mw-page-title-main">PPM1A</span> Protein-coding gene in the species Homo sapiens

Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.

<span class="mw-page-title-main">Transcription elongation regulator 1</span> Protein-coding gene in the species Homo sapiens

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.

<span class="mw-page-title-main">CTDSPL</span> Protein-coding gene in the species Homo sapiens

CTD small phosphatase-like protein is an enzyme that in humans is encoded by the CTDSPL gene.

<span class="mw-page-title-main">SNAPC2</span> Protein-coding gene in the species Homo sapiens

snRNA-activating protein complex subunit 2 is a protein that in humans is encoded by the SNAPC2 gene.

<span class="mw-page-title-main">GTF2F1</span> Protein-coding gene in the species Homo sapiens

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.

<span class="mw-page-title-main">GTF2F2</span> Protein-coding gene in the species Homo sapiens

General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.

<span class="mw-page-title-main">SNAPC4</span> Protein-coding gene in the species Homo sapiens

snRNA-activating protein complex subunit 4 is a protein that in humans is encoded by the SNAPC4 gene.

<span class="mw-page-title-main">MED26</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 26 is an enzyme that in humans is encoded by the MED26 gene. It forms part of the Mediator complex.

<span class="mw-page-title-main">CTDSP2</span> Protein-coding gene in the species Homo sapiens

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 is an enzyme that in humans is encoded by the CTDSP2 gene.

<span class="mw-page-title-main">Auxilin</span> Protein-coding gene in the species Homo sapiens

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.

RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins.

<span class="mw-page-title-main">GTF2E1</span> Human protein-coding gene

General transcription factor IIE subunit 1 (GTF2E1), also known as transcription initiation factor IIE subunit alpha (TFIIE-alpha), is a protein that in humans is encoded by the GTF2E1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144579 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026176 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". Journal of Human Genetics. 47 (3): 140–5. doi: 10.1007/s100380200016 . PMID   11950066.
  6. ↑ Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi: 10.1074/jbc.M301791200 . PMID   12721286.
  7. ↑ "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
  8. ↑ Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi: 10.1074/jbc.M806916200 . PMC   2610500 . PMID   19004823.

Further reading

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