CTDSP2

CTDSP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q5E
Identifiers
Aliases	CTDSP2 , OS4, PSR2, SCP2, CTD small phosphatase 2
External IDs	OMIM: 608711; MGI: 1098748; HomoloGene: 128791; GeneCards: CTDSP2; OMA:CTDSP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q14.1 Start 57,819,927 bp [1] End 57,846,729 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 D3|10 74.35 cM Start 126,814,586 bp [2] End 126,835,844 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa stromal cell of endometrium Descending thoracic aorta body of uterus left ovary right coronary artery right lung right ovary left uterine tube muscle layer of sigmoid colon Top expressed in ventricular zone lip genital tubercle zone of skin urinary bladder skeletal muscle tissue muscle of thigh esophagus uterus lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II CTD heptapeptide repeat phosphatase activity phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity metal ion binding Cellular component nucleus nucleoplasm Biological process negative regulation of G1/S transition of mitotic cell cycle negative regulation of protein phosphorylation protein dephosphorylation IRE1-mediated unfolded protein response regulation of transcription by RNA polymerase II dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10106 52468 Ensembl ENSG00000175215 ENSMUSG00000078429 UniProt O14595 Q8BX07 RefSeq (mRNA) NM_005730 NM_001113470 NM_146012 RefSeq (protein) NP_005721 NP_005721.3 NP_001106941 NP_666124 Location (UCSC) Chr 12: 57.82 – 57.85 Mb Chr 10: 126.81 – 126.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 is an enzyme that in humans is encoded by the CTDSP2 gene. ^{[5] [6] [7]}

Interactions

CTDSP2 has been shown to interact with SNAI1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000175215 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078429 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Su YA, Lee MM, Hutter CM, Meltzer PS (September 1997). "Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas". Oncogene. 15 (11): 1289–94. doi: 10.1038/sj.onc.1201294 . PMID   9315096.
6. Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi: 10.1074/jbc.M301791200 . PMID   12721286.
7. "Entrez Gene: CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2".
8. Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi: 10.1074/jbc.M806916200 . PMC   2610500 . PMID   19004823.

Further reading

• Su YA, Trent JM, Guan XY, Meltzer PS (September 1994). "Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection". Proceedings of the National Academy of Sciences of the United States of America. 91 (19): 9121–5. Bibcode:1994PNAS...91.9121S. doi: 10.1073/pnas.91.19.9121 . PMC   44759 . PMID   8090779.
• Beutler E, Gelbart T, West C, Kuhl W, Lee P (1996). "A strategy for cloning the hereditary hemochromatosis gene". Blood Cells, Molecules & Diseases. 21 (3): 207–16. doi:10.1006/bcmd.1995.0024. PMID   8673473.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Thompson J, Lepikhova T, Teixido-Travesa N, Whitehead MA, Palvimo JJ, Jänne OA (June 2006). "Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription". The EMBO Journal. 25 (12): 2757–67. doi:10.1038/sj.emboj.7601161. PMC   1500849 . PMID   16724108.

External links

• CTDSP2 human gene location in the UCSC Genome Browser .
• CTDSP2 human gene details in the UCSC Genome Browser .
• Human SCP2 genome location and SCP2 gene details page in the UCSC Genome Browser .