CTDSPL

CTDSPL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HHL
Identifiers
Aliases	CTDSPL , C3orf8, HYA22, PSR1, RBSP3, SCP3, CTD small phosphatase like
External IDs	OMIM: 608592 MGI: 1916524 HomoloGene: 48881 GeneCards: CTDSPL
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p22.2 Start 37,861,880 bp [1] End 37,984,469 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F3 Start 118,755,521 bp [2] End 118,873,066 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in metanephric glomerulus nipple renal medulla parotid gland tibia cardia secondary oocyte pylorus hair follicle urethra Top expressed in renal corpuscle right lung left lung right lung lobe medullary collecting duct left lung lobe proximal tubule retinal pigment epithelium ciliary body white adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase activity phosphoprotein phosphatase activity hydrolase activity metal ion binding protein binding molecular function RNA polymerase II CTD heptapeptide repeat phosphatase activity Cellular component extracellular exosome nucleus Biological process negative regulation of G1/S transition of mitotic cell cycle negative regulation of protein phosphorylation dephosphorylation protein dephosphorylation regulation of transcription by RNA polymerase II biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10217 69274 Ensembl ENSG00000144677 ENSMUSG00000047409 UniProt O15194 P58465 RefSeq (mRNA) NM_005808 NM_001008392 NM_133710 RefSeq (protein) NP_001008393 NP_005799 NP_598471 Location (UCSC) Chr 3: 37.86 – 37.98 Mb Chr 9: 118.76 – 118.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CTD small phosphatase-like protein is an enzyme that in humans is encoded by the CTDSPL gene. ^{[5] [6] [7]}

Interactions

CTDSPL has been shown to interact with SNAI1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000144677 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047409 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa S, Kai M, Tamari M, Takei Y, Takeuchi K, Bandou H, Yamane Y, Ogawa M, Nakamura Y (Aug 1997). "Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line". DNA Res. 4 (1): 35–43. doi: 10.1093/dnares/4.1.35 . PMID   9179494.
6. Protopopov A, Kashuba V, Zabarovska VI, Muravenko OV, Lerman MI, Klein G, Zabarovsky ER (Jan 2003). "An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies". Cancer Res. 63 (2): 404–12. PMID   12543795.
7. "Entrez Gene: CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like".
8. Wu, Yadi; Evers B Mark; Zhou Binhua P (Jan 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. United States. 284 (1): 640–8. doi: 10.1074/jbc.M806916200 . ISSN   0021-9258. PMC   2610500 . PMID   19004823.

Further reading

• O'Keeffe B, Fong Y, Chen D, et al. (2000). "Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription". J. Biol. Chem. 275 (1): 279–87. doi:10.1074/jbc.275.1.279. PMID   10617616.
• Kim JB, Sharp PA (2001). "Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase". J. Biol. Chem. 276 (15): 12317–23. doi: 10.1074/jbc.M010908200 . PMID   11145967.
• Ramanathan Y, Rajpara SM, Reza SM, et al. (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences". J. Biol. Chem. 276 (14): 10913–20. doi: 10.1074/jbc.M010975200 . PMID   11278802.
• Zhou M, Nekhai S, Bharucha DC, et al. (2002). "TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription". J. Biol. Chem. 276 (48): 44633–40. doi: 10.1074/jbc.M107466200 . PMID   11572868.
• Lin X, Taube R, Fujinaga K, Peterlin BM (2002). "P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA". J. Biol. Chem. 277 (19): 16873–8. doi: 10.1074/jbc.M200117200 . PMID   11884399.
• Kim YK, Bourgeois CF, Isel C, et al. (2002). "Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation". Mol. Cell. Biol. 22 (13): 4622–37. doi:10.1128/MCB.22.13.4622-4637.2002. PMC   133925 . PMID   12052871.
• Yeo M, Lin PS, Dahmus ME, Gill GN (2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". J. Biol. Chem. 278 (28): 26078–85. doi: 10.1074/jbc.M301791200 . PMID   12721286.
• Pinhero R, Liaw P, Bertens K, Yankulov K (2004). "Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II". Eur. J. Biochem. 271 (5): 1004–14. doi: 10.1111/j.1432-1033.2004.04002.x . PMID   15009212.
• Kashuba VI, Li J, Wang F, et al. (2004). "RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies". Proc. Natl. Acad. Sci. U.S.A. 101 (14): 4906–11. Bibcode:2004PNAS..101.4906K. doi: 10.1073/pnas.0401238101 . PMC   387347 . PMID   15051889.

External links

• CTDSPL human gene location in the UCSC Genome Browser .
• CTDSPL human gene details in the UCSC Genome Browser .